Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01762:Vmn2r7'

153259

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r7

Ensembl Gene

ENSMUSG00000116028

Gene Name

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.100) question?

Stock #

IGL01762

Quality Score

Status

Chromosome

Chromosomal Location

64690660-64719602 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 64691435 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 567 (D567G)

Ref Sequence

ENSEMBL: ENSMUSP00000131220 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000161972] [ENSMUST00000168072]

Predicted Effect

probably benign
Transcript: ENSMUST00000161972
AA Change: D658G

PolyPhen 2 Score 0.216 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000124192
Gene: ENSMUSG00000062200
AA Change: D658G

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	90	507	3.8e-77	PFAM
Pfam:NCD3G	549	602	3.4e-17	PFAM
Pfam:7tm_3	635	869	1.1e-47	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000168072
AA Change: D567G

PolyPhen 2 Score 0.389 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000131220
Gene: ENSMUSG00000116028
AA Change: D567G

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	416	5.1e-72	PFAM
Pfam:Peripla_BP_6	63	245	6.1e-10	PFAM
Pfam:NCD3G	458	511	1.8e-17	PFAM
Pfam:7tm_3	542	779	4.3e-76	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177146

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9030612E09Rik	T	A	10: 43,174,851	L47*	probably null	Het
Abca13	A	T	11: 9,315,423	T3033S	probably benign	Het
Atp1a2	C	A	1: 172,284,913	V503L	possibly damaging	Het
BC030867	T	C	11: 102,255,596	C233R	probably benign	Het
Cacna1e	T	A	1: 154,471,373	D770V	possibly damaging	Het
Camkk1	A	G	11: 73,030,801		probably null	Het
Cd34	T	A	1: 194,939,033	M23K	probably benign	Het
Cndp1	T	A	18: 84,622,286	I265F	probably damaging	Het
Cux2	A	G	5: 121,873,145	I574T	probably damaging	Het
Fam129a	T	C	1: 151,636,491	V48A	probably damaging	Het
Fhdc1	G	A	3: 84,444,735	A1061V	possibly damaging	Het
Galk1	A	G	11: 116,010,008	Y236H	probably damaging	Het
Gbp11	T	C	5: 105,327,607	I292V	probably benign	Het
Gprc5c	A	G	11: 114,864,024	I176V	probably benign	Het
Myh6	T	C	14: 54,962,081	K258E	probably benign	Het
Nlrp9c	T	A	7: 26,385,425	D243V	probably damaging	Het
Nobox	T	G	6: 43,303,993	K516Q	probably damaging	Het
Nudcd3	A	G	11: 6,150,560	S195P	probably damaging	Het
Pde10a	T	C	17: 8,942,918	I477T	possibly damaging	Het
Pgbd5	C	T	8: 124,370,610	A394T	probably damaging	Het
Piezo1	G	A	8: 122,487,929	R1553*	probably null	Het
Prkd1	T	C	12: 50,387,230	I577V	probably benign	Het
Prss34	T	C	17: 25,299,812	I256T	probably benign	Het
Ptprg	A	G	14: 12,037,386	T189A	probably benign	Het
Ptprr	C	T	10: 116,236,733	T200I	probably damaging	Het
Samd8	C	T	14: 21,780,100	P198L	probably damaging	Het
Sema3c	T	C	5: 17,694,851	L447P	possibly damaging	Het
Slc22a23	A	T	13: 34,204,001	F371I	possibly damaging	Het
Slc2a2	A	G	3: 28,717,472	R184G	probably damaging	Het
Slitrk6	T	A	14: 110,751,624	D217V	probably damaging	Het
Tlr2	A	G	3: 83,836,994	V594A	probably benign	Het
Vmn2r109	A	G	17: 20,554,392	F234L	probably benign	Het
Vmn2r12	A	C	5: 109,086,564	L594R	probably damaging	Het
Vmn2r124	A	G	17: 18,063,172	Q376R	possibly damaging	Het

Other mutations in Vmn2r7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00961:Vmn2r7	APN	3	64715813	missense	possibly damaging	0.60
IGL01903:Vmn2r7	APN	3	64719443	missense	probably benign	0.00
IGL02263:Vmn2r7	APN	3	64691447	missense	probably damaging	1.00
IGL02458:Vmn2r7	APN	3	64693025	missense	probably damaging	0.97
IGL02593:Vmn2r7	APN	3	64693022	missense	probably damaging	1.00
IGL02797:Vmn2r7	APN	3	64691245	missense	possibly damaging	0.80
IGL03047:Vmn2r7	UTSW	3	64707218	missense	possibly damaging	0.81
PIT4504001:Vmn2r7	UTSW	3	64715976	missense	probably benign	0.01
R0193:Vmn2r7	UTSW	3	64691039	missense	probably damaging	1.00
R0329:Vmn2r7	UTSW	3	64691018	missense	probably damaging	1.00
R0609:Vmn2r7	UTSW	3	64716479	missense	probably benign	0.44
R0735:Vmn2r7	UTSW	3	64716367	missense	probably benign	0.02
R0941:Vmn2r7	UTSW	3	64716579	missense	probably benign
R1065:Vmn2r7	UTSW	3	64707138	missense	possibly damaging	0.82
R1378:Vmn2r7	UTSW	3	64691604	missense	possibly damaging	0.59
R1445:Vmn2r7	UTSW	3	64724802	missense	probably benign	0.01
R1506:Vmn2r7	UTSW	3	64707079	missense	probably benign
R1509:Vmn2r7	UTSW	3	64716460	nonsense	probably null
R1519:Vmn2r7	UTSW	3	64716455	missense	possibly damaging	0.95
R1706:Vmn2r7	UTSW	3	64691459	missense	possibly damaging	0.79
R2113:Vmn2r7	UTSW	3	64691604	missense	possibly damaging	0.59
R3725:Vmn2r7	UTSW	3	64724991	missense	possibly damaging	0.65
R3874:Vmn2r7	UTSW	3	64719611	missense	possibly damaging	0.69
R3902:Vmn2r7	UTSW	3	64719516	missense	possibly damaging	0.46
R4084:Vmn2r7	UTSW	3	64692993	missense	probably benign	0.08
R4117:Vmn2r7	UTSW	3	64715717	intron	probably benign
R4333:Vmn2r7	UTSW	3	64690778	missense	probably damaging	1.00
R4551:Vmn2r7	UTSW	3	64690689	missense	possibly damaging	0.86
R4643:Vmn2r7	UTSW	3	64716404	missense	probably damaging	1.00
R4654:Vmn2r7	UTSW	3	64719443	missense	probably benign	0.00
R5091:Vmn2r7	UTSW	3	64690784	missense	possibly damaging	0.63
R5109:Vmn2r7	UTSW	3	64690667	missense	probably null	0.84
R5372:Vmn2r7	UTSW	3	64716324	missense	probably damaging	1.00
R5415:Vmn2r7	UTSW	3	64716237	missense	probably benign	0.07
R5740:Vmn2r7	UTSW	3	64707233	missense	probably benign
R5977:Vmn2r7	UTSW	3	64716043	nonsense	probably null
R6019:Vmn2r7	UTSW	3	64716222	missense	probably damaging	1.00
R6058:Vmn2r7	UTSW	3	64725015	missense	probably benign	0.00
R6139:Vmn2r7	UTSW	3	64715918	missense	probably damaging	1.00
R6696:Vmn2r7	UTSW	3	64707074	missense	probably benign	0.01
R6887:Vmn2r7	UTSW	3	64690827	missense	probably damaging	1.00
R6918:Vmn2r7	UTSW	3	64691339	missense	probably benign	0.03
R6949:Vmn2r7	UTSW	3	64691121	missense	probably damaging	0.99
R6980:Vmn2r7	UTSW	3	64716566	missense	possibly damaging	0.67
R7196:Vmn2r7	UTSW	3	64715777	missense	probably benign	0.00
R7286:Vmn2r7	UTSW	3	64690880	missense	probably benign	0.00
R7455:Vmn2r7	UTSW	3	64716593	missense	probably benign
R7557:Vmn2r7	UTSW	3	64724973	missense	probably benign
R7864:Vmn2r7	UTSW	3	64691526	missense	probably benign	0.10
R7947:Vmn2r7	UTSW	3	64691526	missense	probably benign	0.10

Posted On

2014-02-04