Incidental Mutation 'IGL00095:Crxos'
ID1533
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Crxos
Ensembl Gene ENSMUSG00000074365
Gene Namecone-rod homeobox, opposite strand
SynonymsCrxos1, Egam1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.113) question?
Stock #IGL00095
Quality Score
Status
Chromosome7
Chromosomal Location15882617-15904020 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 15898618 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 116 (C116*)
Ref Sequence ENSEMBL: ENSMUSP00000133563 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098801] [ENSMUST00000125993] [ENSMUST00000130566] [ENSMUST00000150050] [ENSMUST00000171280] [ENSMUST00000173808]
Predicted Effect probably null
Transcript: ENSMUST00000098801
SMART Domains Protein: ENSMUSP00000096399
Gene: ENSMUSG00000074365

DomainStartEndE-ValueType
HOX 13 75 6.06e-4 SMART
HOX 123 185 3.93e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000125993
AA Change: C71*
SMART Domains Protein: ENSMUSP00000139388
Gene: ENSMUSG00000074365
AA Change: C71*

DomainStartEndE-ValueType
Blast:HOX 1 30 8e-13 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000130566
SMART Domains Protein: ENSMUSP00000138909
Gene: ENSMUSG00000074365

DomainStartEndE-ValueType
Blast:HOX 1 30 1e-12 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000150050
AA Change: C116*
SMART Domains Protein: ENSMUSP00000133563
Gene: ENSMUSG00000074365
AA Change: C116*

DomainStartEndE-ValueType
HOX 13 75 6.06e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000171280
SMART Domains Protein: ENSMUSP00000130485
Gene: ENSMUSG00000074365

DomainStartEndE-ValueType
HOX 19 81 3.93e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173808
SMART Domains Protein: ENSMUSP00000138891
Gene: ENSMUSG00000074365

DomainStartEndE-ValueType
Pfam:Homeobox 8 50 2.4e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cadm2 A T 16: 66,882,751 Y65N probably damaging Het
Catsperg2 C A 7: 29,698,058 C1042F possibly damaging Het
Cluh T C 11: 74,664,064 V776A probably benign Het
Csmd1 A G 8: 16,009,297 probably benign Het
Cubn C A 2: 13,491,820 probably benign Het
Exoc2 A G 13: 30,820,626 I858T probably benign Het
Fam105a A G 15: 27,658,116 S273P possibly damaging Het
Frmpd1 C A 4: 45,279,456 T727K possibly damaging Het
Gm3139 T C 5: 94,537,804 L441P probably damaging Het
Hapln3 T C 7: 79,121,983 T53A probably damaging Het
Hnrnpul1 T A 7: 25,726,154 Q584L possibly damaging Het
Ikbkb A T 8: 22,706,111 F26I probably damaging Het
Il31ra A T 13: 112,547,478 I120N possibly damaging Het
Itih1 C T 14: 30,929,821 V855M probably benign Het
Krtap4-16 A G 11: 99,851,206 S123P possibly damaging Het
Large1 C T 8: 72,837,497 R547Q probably damaging Het
Madd A G 2: 91,175,766 probably benign Het
Mark1 A G 1: 184,898,603 V770A probably damaging Het
Mpeg1 T C 19: 12,462,710 F511L probably benign Het
Mrgpra9 A G 7: 47,235,091 V276A possibly damaging Het
Nav3 T C 10: 109,841,733 T666A probably damaging Het
Ndufa8 T C 2: 36,044,455 D37G probably damaging Het
Nlrx1 A G 9: 44,253,279 L956P probably damaging Het
Nr5a1 T C 2: 38,708,341 E148G probably benign Het
Olfr310 T C 7: 86,269,669 N40S probably damaging Het
Olfr509 A T 7: 108,645,836 F247I possibly damaging Het
Patj A C 4: 98,535,562 Q1184P possibly damaging Het
Phf20l1 A G 15: 66,629,035 T619A probably benign Het
Pla2g6 T C 15: 79,289,241 T643A probably damaging Het
Radil A G 5: 142,497,922 S510P probably damaging Het
Spock1 A G 13: 57,587,739 probably benign Het
Stag3 C T 5: 138,299,138 T577M probably damaging Het
Tap2 C T 17: 34,215,378 R613C probably benign Het
Tnn A G 1: 160,125,451 V673A possibly damaging Het
Trrap T C 5: 144,779,974 probably benign Het
Vmn2r28 T C 7: 5,488,069 D393G probably benign Het
Zbtb48 T C 4: 152,021,394 H418R probably damaging Het
Zc3h12d T C 10: 7,862,467 V179A probably damaging Het
Other mutations in Crxos
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02888:Crxos APN 7 15902930 missense possibly damaging 0.71
R0060:Crxos UTSW 7 15898523 missense possibly damaging 0.94
R0491:Crxos UTSW 7 15898535 missense probably benign 0.01
R5111:Crxos UTSW 7 15896217 unclassified probably benign
R6185:Crxos UTSW 7 15902880 missense possibly damaging 0.71
R7474:Crxos UTSW 7 15902931 missense possibly damaging 0.85
R8223:Crxos UTSW 7 15897469 missense probably benign 0.00
Posted On2011-07-12