Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00095:Crxos'

1533

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Crxos

Ensembl Gene

ENSMUSG00000074365

Gene Name

cone-rod homeobox, opposite strand

Synonyms

Egam1, Crxos1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL00095

Quality Score

Status

Chromosome

Chromosomal Location

15616542-15637945 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 15632543 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 116 (C116*)

Ref Sequence

ENSEMBL: ENSMUSP00000133563 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098801] [ENSMUST00000125993] [ENSMUST00000130566] [ENSMUST00000150050] [ENSMUST00000171280] [ENSMUST00000173808]

AlphaFold

Q3UL53

Predicted Effect

probably null
Transcript: ENSMUST00000098801

SMART Domains

Protein: ENSMUSP00000096399
Gene: ENSMUSG00000074365

Domain	Start	End	E-Value	Type
HOX	13	75	6.06e-4	SMART
HOX	123	185	3.93e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000125993
AA Change: C71*

SMART Domains

Protein: ENSMUSP00000139388
Gene: ENSMUSG00000074365
AA Change: C71*

Domain	Start	End	E-Value	Type
Blast:HOX	1	30	8e-13	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000130566

SMART Domains

Protein: ENSMUSP00000138909
Gene: ENSMUSG00000074365

Domain	Start	End	E-Value	Type
Blast:HOX	1	30	1e-12	BLAST

Predicted Effect

probably null
Transcript: ENSMUST00000150050
AA Change: C116*

SMART Domains

Protein: ENSMUSP00000133563
Gene: ENSMUSG00000074365
AA Change: C116*

Domain	Start	End	E-Value	Type
HOX	13	75	6.06e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000171280

SMART Domains

Protein: ENSMUSP00000130485
Gene: ENSMUSG00000074365

Domain	Start	End	E-Value	Type
HOX	19	81	3.93e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000173808

SMART Domains

Protein: ENSMUSP00000138891
Gene: ENSMUSG00000074365

Domain	Start	End	E-Value	Type
Pfam:Homeobox	8	50	2.4e-11	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cadm2	A	T	16: 66,679,639 (GRCm39)	Y65N	probably damaging	Het
Catsperg2	C	A	7: 29,397,483 (GRCm39)	C1042F	possibly damaging	Het
Cluh	T	C	11: 74,554,890 (GRCm39)	V776A	probably benign	Het
Csmd1	A	G	8: 16,059,297 (GRCm39)		probably benign	Het
Cubn	C	A	2: 13,496,631 (GRCm39)		probably benign	Het
Exoc2	A	G	13: 31,004,609 (GRCm39)	I858T	probably benign	Het
Frmpd1	C	A	4: 45,279,456 (GRCm39)	T727K	possibly damaging	Het
Hapln3	T	C	7: 78,771,731 (GRCm39)	T53A	probably damaging	Het
Hnrnpul1	T	A	7: 25,425,579 (GRCm39)	Q584L	possibly damaging	Het
Ikbkb	A	T	8: 23,196,127 (GRCm39)	F26I	probably damaging	Het
Il31ra	A	T	13: 112,684,012 (GRCm39)	I120N	possibly damaging	Het
Itih1	C	T	14: 30,651,778 (GRCm39)	V855M	probably benign	Het
Krtap4-16	A	G	11: 99,742,032 (GRCm39)	S123P	possibly damaging	Het
Large1	C	T	8: 73,564,125 (GRCm39)	R547Q	probably damaging	Het
Madd	A	G	2: 91,006,111 (GRCm39)		probably benign	Het
Mark1	A	G	1: 184,630,800 (GRCm39)	V770A	probably damaging	Het
Mpeg1	T	C	19: 12,440,074 (GRCm39)	F511L	probably benign	Het
Mrgpra9	A	G	7: 46,884,839 (GRCm39)	V276A	possibly damaging	Het
Nav3	T	C	10: 109,677,594 (GRCm39)	T666A	probably damaging	Het
Ndufa8	T	C	2: 35,934,467 (GRCm39)	D37G	probably damaging	Het
Nlrx1	A	G	9: 44,164,576 (GRCm39)	L956P	probably damaging	Het
Nr5a1	T	C	2: 38,598,353 (GRCm39)	E148G	probably benign	Het
Or10ab5	A	T	7: 108,245,043 (GRCm39)	F247I	possibly damaging	Het
Or14c46	T	C	7: 85,918,877 (GRCm39)	N40S	probably damaging	Het
Otulinl	A	G	15: 27,658,202 (GRCm39)	S273P	possibly damaging	Het
Patj	A	C	4: 98,423,799 (GRCm39)	Q1184P	possibly damaging	Het
Phf20l1	A	G	15: 66,500,884 (GRCm39)	T619A	probably benign	Het
Pla2g6	T	C	15: 79,173,441 (GRCm39)	T643A	probably damaging	Het
Pramel42	T	C	5: 94,685,663 (GRCm39)	L441P	probably damaging	Het
Radil	A	G	5: 142,483,677 (GRCm39)	S510P	probably damaging	Het
Spock1	A	G	13: 57,735,552 (GRCm39)		probably benign	Het
Stag3	C	T	5: 138,297,400 (GRCm39)	T577M	probably damaging	Het
Tap2	C	T	17: 34,434,352 (GRCm39)	R613C	probably benign	Het
Tnn	A	G	1: 159,953,021 (GRCm39)	V673A	possibly damaging	Het
Trrap	T	C	5: 144,716,784 (GRCm39)		probably benign	Het
Vmn2r28	T	C	7: 5,491,068 (GRCm39)	D393G	probably benign	Het
Zbtb48	T	C	4: 152,105,851 (GRCm39)	H418R	probably damaging	Het
Zc3h12d	T	C	10: 7,738,231 (GRCm39)	V179A	probably damaging	Het

Other mutations in Crxos

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02888:Crxos	APN	7	15,636,855 (GRCm39)	missense	possibly damaging	0.71
R0060:Crxos	UTSW	7	15,632,448 (GRCm39)	missense	possibly damaging	0.94
R0491:Crxos	UTSW	7	15,632,460 (GRCm39)	missense	probably benign	0.01
R5111:Crxos	UTSW	7	15,630,142 (GRCm39)	unclassified	probably benign
R6185:Crxos	UTSW	7	15,636,805 (GRCm39)	missense	possibly damaging	0.71
R7474:Crxos	UTSW	7	15,636,856 (GRCm39)	missense	possibly damaging	0.85
R8223:Crxos	UTSW	7	15,631,394 (GRCm39)	missense	probably benign	0.00
R8488:Crxos	UTSW	7	15,637,625 (GRCm39)	missense	possibly damaging	0.92
R8788:Crxos	UTSW	7	15,632,499 (GRCm39)	missense	probably benign	0.01
R8944:Crxos	UTSW	7	15,636,900 (GRCm39)	missense	possibly damaging	0.95
R9156:Crxos	UTSW	7	15,631,436 (GRCm39)	missense	probably benign	0.14
R9221:Crxos	UTSW	7	15,636,850 (GRCm39)	missense	probably benign	0.03

Posted On

2011-07-12