Incidental Mutation 'IGL01765:Olfr419'
ID153320
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr419
Ensembl Gene ENSMUSG00000050788
Gene Nameolfactory receptor 419
SynonymsMOR267-6, GA_x6K02T2P20D-20891507-20892448
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.098) question?
Stock #IGL01765
Quality Score
Status
Chromosome1
Chromosomal Location174248514-174252061 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 174250137 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Asparagine at position 263 (K263N)
Ref Sequence ENSEMBL: ENSMUSP00000149512 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027817] [ENSMUST00000061990] [ENSMUST00000214725]
Predicted Effect probably benign
Transcript: ENSMUST00000027817
SMART Domains Protein: ENSMUSP00000027817
Gene: ENSMUSG00000026532

DomainStartEndE-ValueType
SPEC 55 153 3.62e-11 SMART
SPEC 159 259 1.84e-26 SMART
SPEC 265 365 1.56e-24 SMART
SPEC 371 471 8.35e-25 SMART
SPEC 477 577 1.19e-29 SMART
SPEC 583 682 2.43e-26 SMART
SPEC 688 788 1.3e-26 SMART
SPEC 794 894 1.66e-28 SMART
SPEC 900 1077 5.03e-19 SMART
SH3 978 1033 2.98e-15 SMART
SPEC 1083 1178 2.57e-16 SMART
SPEC 1184 1284 1.15e-27 SMART
SPEC 1290 1390 7.05e-23 SMART
SPEC 1396 1495 6.04e-22 SMART
SPEC 1501 1602 1.15e-27 SMART
SPEC 1608 1708 5.46e-29 SMART
SPEC 1714 1814 1.08e-32 SMART
SPEC 1820 1921 2.17e-23 SMART
SPEC 1927 2028 2.19e-19 SMART
SPEC 2042 2142 3.87e-11 SMART
SPEC 2156 2253 9.77e-8 SMART
low complexity region 2307 2318 N/A INTRINSIC
efhand_Ca_insen 2346 2414 2.37e-27 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000061990
AA Change: K263N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000050893
Gene: ENSMUSG00000050788
AA Change: K263N

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.4e-53 PFAM
Pfam:7tm_1 41 290 3.2e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156092
Predicted Effect probably damaging
Transcript: ENSMUST00000214725
AA Change: K263N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf2 A T 17: 42,719,535 M11K probably benign Het
Agap2 T C 10: 127,083,235 V442A unknown Het
B020004J07Rik T C 4: 101,837,852 I87M probably benign Het
Cdh7 C T 1: 110,061,106 T246I probably damaging Het
Creb3l1 T C 2: 92,024,101 D2G possibly damaging Het
Dicer1 G A 12: 104,706,740 R811C probably damaging Het
Drosha C A 15: 12,902,680 A1012E probably damaging Het
Eftud2 A G 11: 102,839,256 I896T probably damaging Het
Fastkd5 T C 2: 130,615,734 Y312C possibly damaging Het
Flt3 A G 5: 147,357,978 F428L probably benign Het
Hrh4 G A 18: 13,007,195 R49Q probably damaging Het
Lrp6 T C 6: 134,456,145 T1408A probably damaging Het
Lsg1 T C 16: 30,582,095 E132G probably damaging Het
Ltf T C 9: 111,022,017 V99A possibly damaging Het
Mettl13 A T 1: 162,538,953 D452E probably benign Het
Ndufa7 G T 17: 33,829,812 E83* probably null Het
Nmrk1 C T 19: 18,639,538 T17M probably damaging Het
Ntsr1 A G 2: 180,538,717 E272G possibly damaging Het
Obscn T C 11: 59,115,784 K1184R possibly damaging Het
Olfr1240 C T 2: 89,439,800 V160I probably benign Het
Olfr134 G T 17: 38,175,686 V201L probably benign Het
Olfr380 A C 11: 73,453,477 L245R probably damaging Het
Olfr736 A T 14: 50,392,834 Q26L probably benign Het
Olfr862 A T 9: 19,883,951 M118K possibly damaging Het
Pcdhb10 A G 18: 37,414,019 K716R probably benign Het
Phldb3 A G 7: 24,617,375 D267G possibly damaging Het
Plcb2 T A 2: 118,710,268 probably benign Het
Pusl1 A G 4: 155,889,713 F219L probably damaging Het
Rbbp6 T C 7: 122,999,954 probably benign Het
Rev3l T A 10: 39,828,265 D228E probably benign Het
Rnf213 A T 11: 119,436,352 M1723L probably benign Het
Sc5d A G 9: 42,256,168 F128S probably damaging Het
Sco1 T C 11: 67,053,790 S80P probably damaging Het
Supt16 C T 14: 52,180,223 R278H probably damaging Het
Supt6 A G 11: 78,222,159 I986T probably benign Het
Trio A G 15: 27,764,026 V860A possibly damaging Het
Uck1 A G 2: 32,258,676 probably benign Het
Vmn2r63 T C 7: 42,903,364 T823A probably benign Het
Other mutations in Olfr419
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01133:Olfr419 APN 1 174250526 missense probably benign 0.41
IGL02718:Olfr419 APN 1 174250707 nonsense probably null
IGL03208:Olfr419 APN 1 174250393 missense probably damaging 1.00
R1406:Olfr419 UTSW 1 174250861 missense possibly damaging 0.51
R1406:Olfr419 UTSW 1 174250861 missense possibly damaging 0.51
R1760:Olfr419 UTSW 1 174250360 missense probably damaging 0.99
R2138:Olfr419 UTSW 1 174250736 unclassified probably null
R2139:Olfr419 UTSW 1 174250736 unclassified probably null
R2869:Olfr419 UTSW 1 174250526 missense probably benign 0.41
R2869:Olfr419 UTSW 1 174250526 missense probably benign 0.41
R2871:Olfr419 UTSW 1 174250526 missense probably benign 0.41
R2871:Olfr419 UTSW 1 174250526 missense probably benign 0.41
R2872:Olfr419 UTSW 1 174250526 missense probably benign 0.41
R2872:Olfr419 UTSW 1 174250526 missense probably benign 0.41
R2873:Olfr419 UTSW 1 174250526 missense probably benign 0.41
R2874:Olfr419 UTSW 1 174250526 missense probably benign 0.41
R3854:Olfr419 UTSW 1 174250150 missense probably damaging 1.00
R4614:Olfr419 UTSW 1 174250622 missense possibly damaging 0.93
R4858:Olfr419 UTSW 1 174250696 missense probably damaging 1.00
R5015:Olfr419 UTSW 1 174250882 missense possibly damaging 0.91
R5138:Olfr419 UTSW 1 174250829 missense probably damaging 0.97
R5296:Olfr419 UTSW 1 174250756 missense possibly damaging 0.75
R5369:Olfr419 UTSW 1 174250441 missense probably damaging 1.00
R6285:Olfr419 UTSW 1 174250829 missense possibly damaging 0.62
R7655:Olfr419 UTSW 1 174250218 missense probably damaging 1.00
R7656:Olfr419 UTSW 1 174250218 missense probably damaging 1.00
R7753:Olfr419 UTSW 1 174250670 missense probably benign 0.01
Posted On2014-02-04