Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01767:Vmn2r78'

153336

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r78

Ensembl Gene

ENSMUSG00000091962

Gene Name

vomeronasal 2, receptor 78

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.091) question?

Stock #

IGL01767

Quality Score

Status

Chromosome

Chromosomal Location

86915300-86955177 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 86954435 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 607 (D607G)

Ref Sequence

ENSEMBL: ENSMUSP00000126698 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170835]

AlphaFold

K7N6U5

Predicted Effect

probably benign
Transcript: ENSMUST00000170835
AA Change: D607G

PolyPhen 2 Score 0.283 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000126698
Gene: ENSMUSG00000091962
AA Change: D607G

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	5.9e-31	PFAM
Pfam:NCD3G	507	559	8.1e-21	PFAM
Pfam:7tm_3	592	827	1e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadat	A	T	8: 60,507,092 (GRCm38)	D31V	probably damaging	Het
Acaca	A	T	11: 84,320,542 (GRCm38)	Y1560F	probably benign	Het
Actl7a	A	G	4: 56,743,980 (GRCm38)	E169G	probably damaging	Het
Adgrb3	A	G	1: 25,559,814 (GRCm38)	V270A	probably benign	Het
Adgre4	G	A	17: 55,797,740 (GRCm38)	V269I	probably benign	Het
Ankhd1	A	G	18: 36,648,374 (GRCm38)	T2160A	probably damaging	Het
Bltp1	T	C	3: 37,041,363 (GRCm38)	V4505A	probably benign	Het
Bnip2	T	A	9: 70,002,116 (GRCm38)		probably benign	Het
Casp16	A	G	17: 23,552,053 (GRCm38)	V126A	probably damaging	Het
Ccser1	C	A	6: 61,718,152 (GRCm38)	T157K	probably benign	Het
Cdh23	A	G	10: 60,315,724 (GRCm38)	S2459P	probably damaging	Het
Cdk5rap3	A	T	11: 96,913,465 (GRCm38)	C21S	probably damaging	Het
Chmp6	G	A	11: 119,916,986 (GRCm38)	E72K	probably benign	Het
Cldn23	T	C	8: 35,825,662 (GRCm38)	Y224C	probably damaging	Het
Cry1	C	T	10: 85,146,474 (GRCm38)	G336D	probably damaging	Het
Cyp4f17	T	A	17: 32,506,982 (GRCm38)	F30I	probably benign	Het
Dgcr8	T	A	16: 18,278,336 (GRCm38)	D496V	probably damaging	Het
Dhx9	A	G	1: 153,468,868 (GRCm38)		probably benign	Het
Dnah10	C	T	5: 124,743,737 (GRCm38)		probably benign	Het
Dock9	T	C	14: 121,622,870 (GRCm38)	E880G	possibly damaging	Het
Dscam	A	G	16: 96,654,936 (GRCm38)	V1264A	probably damaging	Het
Eno1	T	C	4: 150,246,710 (GRCm38)	Y270H	probably benign	Het
Eprs1	A	G	1: 185,384,915 (GRCm38)	D385G	probably damaging	Het
Ercc2	A	G	7: 19,390,421 (GRCm38)	Y215C	probably damaging	Het
Fscn2	A	G	11: 120,367,750 (GRCm38)	N400S	possibly damaging	Het
Fuca1	C	T	4: 135,939,201 (GRCm38)	T449I	probably benign	Het
Gm43638	T	C	5: 87,465,431 (GRCm38)	K492E	probably damaging	Het
Gm5263	T	G	1: 146,420,564 (GRCm38)		noncoding transcript	Het
Gm8122	T	C	14: 43,232,701 (GRCm38)	T111A	unknown	Het
Gtf3c2	T	A	5: 31,157,635 (GRCm38)	N923Y	probably benign	Het
Il17a	T	A	1: 20,733,640 (GRCm38)	D86E	probably benign	Het
Itgb2l	G	T	16: 96,430,575 (GRCm38)	N330K	probably benign	Het
Kcnj11	T	C	7: 46,099,065 (GRCm38)	H278R	probably benign	Het
Khdrbs2	T	A	1: 32,619,176 (GRCm38)	Y272*	probably null	Het
Kndc1	A	T	7: 139,930,046 (GRCm38)	Q1267L	probably damaging	Het
Loxhd1	T	A	18: 77,286,424 (GRCm38)	F64I	possibly damaging	Het
Lrig2	T	A	3: 104,491,545 (GRCm38)	K222N	probably benign	Het
Lrrcc1	T	A	3: 14,547,272 (GRCm38)	Y378N	probably damaging	Het
Mblac2	T	C	13: 81,750,315 (GRCm38)	L270P	probably damaging	Het
Med13	A	T	11: 86,319,783 (GRCm38)	I511N	probably benign	Het
Myo3a	A	T	2: 22,423,222 (GRCm38)	E763D	probably damaging	Het
Or1e25	T	A	11: 73,603,032 (GRCm38)	F151I	probably benign	Het
Or2n1	G	T	17: 38,175,686 (GRCm38)	V201L	probably benign	Het
Or4a68	C	T	2: 89,439,800 (GRCm38)	V160I	probably benign	Het
Or5b97	T	A	19: 12,901,748 (GRCm38)	T11S	probably benign	Het
Or7g27	G	A	9: 19,339,302 (GRCm38)	V281I	possibly damaging	Het
Plxna4	T	A	6: 32,237,678 (GRCm38)	I623F	possibly damaging	Het
Ppp2ca	T	A	11: 52,118,055 (GRCm38)	Y127*	probably null	Het
Psg18	A	G	7: 18,353,397 (GRCm38)	V112A	possibly damaging	Het
Ptprj	A	T	2: 90,469,574 (GRCm38)	N108K	probably benign	Het
Rictor	A	G	15: 6,777,384 (GRCm38)	Y707C	probably damaging	Het
Rptn	T	C	3: 93,395,639 (GRCm38)	F93S	probably benign	Het
Rxrg	T	A	1: 167,627,315 (GRCm38)	C156S	probably damaging	Het
Slc24a4	T	C	12: 102,223,687 (GRCm38)		probably benign	Het
Slc25a27	C	T	17: 43,664,073 (GRCm38)		probably null	Het
Slx4	T	C	16: 3,990,248 (GRCm38)	K481E	probably benign	Het
Snx19	T	C	9: 30,463,264 (GRCm38)	W940R	possibly damaging	Het
Spopfm1	T	A	3: 94,266,484 (GRCm38)	D262E	probably benign	Het
Tasor2	G	A	13: 3,576,633 (GRCm38)	P1106S	probably benign	Het
Tcf20	G	A	15: 82,856,008 (GRCm38)	P414L	probably damaging	Het
Treml2	T	C	17: 48,302,810 (GRCm38)	V90A	probably benign	Het
Uckl1	C	T	2: 181,569,534 (GRCm38)	V501M	probably damaging	Het
Unc79	C	T	12: 103,141,997 (GRCm38)	T1937I	probably damaging	Het
Vmn2r17	A	T	5: 109,420,037 (GRCm38)	I9F	probably benign	Het
Vmn2r44	T	C	7: 8,380,238 (GRCm38)	H119R	probably benign	Het
Vps13a	C	T	19: 16,663,894 (GRCm38)	G2288D	probably damaging	Het
Znfx1	G	T	2: 167,055,723 (GRCm38)	T427N	probably damaging	Het

Other mutations in Vmn2r78

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01302:Vmn2r78	APN	7	86,915,361 (GRCm38)	missense	unknown
IGL01473:Vmn2r78	APN	7	86,920,312 (GRCm38)	missense	possibly damaging	0.61
IGL02322:Vmn2r78	APN	7	86,921,479 (GRCm38)	missense	probably damaging	0.96
IGL02537:Vmn2r78	APN	7	86,954,288 (GRCm38)	missense	probably damaging	0.99
IGL03297:Vmn2r78	APN	7	86,920,761 (GRCm38)	nonsense	probably null
ANU74:Vmn2r78	UTSW	7	86,921,065 (GRCm38)	missense	possibly damaging	0.62
R0035:Vmn2r78	UTSW	7	86,920,205 (GRCm38)	missense	probably benign	0.22
R0081:Vmn2r78	UTSW	7	86,923,027 (GRCm38)	missense	probably benign	0.35
R0401:Vmn2r78	UTSW	7	86,921,311 (GRCm38)	missense	probably benign	0.04
R0751:Vmn2r78	UTSW	7	86,954,380 (GRCm38)	missense	possibly damaging	0.77
R1341:Vmn2r78	UTSW	7	86,922,269 (GRCm38)	missense	possibly damaging	0.71
R1386:Vmn2r78	UTSW	7	86,915,407 (GRCm38)	missense	unknown
R1526:Vmn2r78	UTSW	7	86,922,257 (GRCm38)	splice site	probably null
R1712:Vmn2r78	UTSW	7	86,954,924 (GRCm38)	missense	probably damaging	1.00
R1739:Vmn2r78	UTSW	7	86,920,789 (GRCm38)	missense	probably benign
R1812:Vmn2r78	UTSW	7	86,920,787 (GRCm38)	missense	probably benign	0.38
R2011:Vmn2r78	UTSW	7	86,955,079 (GRCm38)	missense	possibly damaging	0.52
R2144:Vmn2r78	UTSW	7	86,954,482 (GRCm38)	missense	probably damaging	1.00
R2197:Vmn2r78	UTSW	7	86,921,327 (GRCm38)	missense	probably damaging	0.96
R2291:Vmn2r78	UTSW	7	86,920,154 (GRCm38)	missense	probably damaging	1.00
R2409:Vmn2r78	UTSW	7	86,920,745 (GRCm38)	splice site	probably benign
R3023:Vmn2r78	UTSW	7	86,954,966 (GRCm38)	missense	probably damaging	1.00
R4486:Vmn2r78	UTSW	7	86,920,751 (GRCm38)	critical splice acceptor site	probably null
R4512:Vmn2r78	UTSW	7	86,920,244 (GRCm38)	missense	probably benign	0.00
R4515:Vmn2r78	UTSW	7	86,954,258 (GRCm38)	missense	probably damaging	0.99
R4544:Vmn2r78	UTSW	7	86,921,191 (GRCm38)	missense	probably benign
R4546:Vmn2r78	UTSW	7	86,954,603 (GRCm38)	missense	probably damaging	1.00
R4872:Vmn2r78	UTSW	7	86,954,708 (GRCm38)	missense	possibly damaging	0.87
R4928:Vmn2r78	UTSW	7	86,954,627 (GRCm38)	missense	probably damaging	1.00
R5101:Vmn2r78	UTSW	7	86,922,355 (GRCm38)	missense	probably damaging	1.00
R5265:Vmn2r78	UTSW	7	86,920,124 (GRCm38)	missense	probably damaging	1.00
R5328:Vmn2r78	UTSW	7	86,921,030 (GRCm38)	missense	probably damaging	0.98
R5442:Vmn2r78	UTSW	7	86,920,122 (GRCm38)	missense	possibly damaging	0.95
R5567:Vmn2r78	UTSW	7	86,921,529 (GRCm38)	missense	probably benign	0.17
R5572:Vmn2r78	UTSW	7	86,915,512 (GRCm38)	missense	probably benign	0.01
R5636:Vmn2r78	UTSW	7	86,954,429 (GRCm38)	missense	probably damaging	0.99
R5901:Vmn2r78	UTSW	7	86,954,588 (GRCm38)	missense	probably damaging	1.00
R5977:Vmn2r78	UTSW	7	86,954,907 (GRCm38)	missense	probably benign	0.00
R5977:Vmn2r78	UTSW	7	86,920,333 (GRCm38)	missense	possibly damaging	0.74
R6276:Vmn2r78	UTSW	7	86,921,110 (GRCm38)	missense	probably benign	0.00
R6386:Vmn2r78	UTSW	7	86,922,337 (GRCm38)	nonsense	probably null
R6724:Vmn2r78	UTSW	7	86,954,258 (GRCm38)	missense	probably damaging	0.99
R6852:Vmn2r78	UTSW	7	86,954,603 (GRCm38)	missense	probably damaging	1.00
R6896:Vmn2r78	UTSW	7	86,922,350 (GRCm38)	missense	probably benign	0.10
R7385:Vmn2r78	UTSW	7	86,922,425 (GRCm38)	missense	probably benign	0.18
R7578:Vmn2r78	UTSW	7	86,954,344 (GRCm38)	nonsense	probably null
R7680:Vmn2r78	UTSW	7	86,954,941 (GRCm38)	missense	probably damaging	1.00
R7748:Vmn2r78	UTSW	7	86,921,135 (GRCm38)	missense	probably benign	0.00
R7852:Vmn2r78	UTSW	7	86,920,170 (GRCm38)	nonsense	probably null
R8031:Vmn2r78	UTSW	7	86,954,867 (GRCm38)	missense	probably damaging	1.00
R8070:Vmn2r78	UTSW	7	86,922,487 (GRCm38)	missense	probably benign	0.01
R8085:Vmn2r78	UTSW	7	86,954,790 (GRCm38)	missense	probably benign	0.00
R8163:Vmn2r78	UTSW	7	86,954,452 (GRCm38)	missense	probably damaging	1.00
R8501:Vmn2r78	UTSW	7	86,920,886 (GRCm38)	missense	probably damaging	0.99
R8749:Vmn2r78	UTSW	7	86,954,305 (GRCm38)	missense	possibly damaging	0.81
R9209:Vmn2r78	UTSW	7	86,920,223 (GRCm38)	missense	probably benign	0.08
RF018:Vmn2r78	UTSW	7	86,954,431 (GRCm38)	nonsense	probably null
Z1177:Vmn2r78	UTSW	7	86,954,774 (GRCm38)	missense	probably benign	0.02
Z1177:Vmn2r78	UTSW	7	86,921,207 (GRCm38)	missense	probably benign	0.44

Posted On

2014-02-04