Incidental Mutation 'IGL01759:Vmn2r124'
ID 153497
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r124
Ensembl Gene ENSMUSG00000094396
Gene Name vomeronasal 2, receptor 124
Synonyms Vmn2r-ps113, Gm7196
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.270) question?
Stock # IGL01759
Quality Score
Status
Chromosome 17
Chromosomal Location 18269746-18294482 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 18284330 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 457 (T457I)
Ref Sequence ENSEMBL: ENSMUSP00000135613 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176802] [ENSMUST00000231546]
AlphaFold K7N789
Predicted Effect probably benign
Transcript: ENSMUST00000176802
AA Change: T457I

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000135613
Gene: ENSMUSG00000094396
AA Change: T457I

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 84 449 2.2e-37 PFAM
Pfam:NCD3G 510 563 9.3e-21 PFAM
Pfam:7tm_3 596 831 1.6e-52 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231546
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi3 A T 11: 95,726,625 (GRCm39) D150E probably damaging Het
Akr1c14 T A 13: 4,131,139 (GRCm39) I277N probably damaging Het
Ap1b1 C T 11: 4,969,433 (GRCm39) T263I probably damaging Het
Atp6v0d2 C A 4: 19,878,335 (GRCm39) V313L probably damaging Het
Car2 G A 3: 14,960,688 (GRCm39) probably null Het
Cdh17 T A 4: 11,771,262 (GRCm39) probably benign Het
Cep295 A G 9: 15,234,855 (GRCm39) probably null Het
Cep97 T C 16: 55,750,936 (GRCm39) K27E probably damaging Het
Cops5 A T 1: 10,097,474 (GRCm39) N258K probably damaging Het
Dchs1 T A 7: 105,404,509 (GRCm39) T2678S probably benign Het
Dnah10 T A 5: 124,832,850 (GRCm39) F861Y probably benign Het
Dock10 T C 1: 80,503,990 (GRCm39) E1777G probably damaging Het
Dock5 G A 14: 68,118,708 (GRCm39) Q23* probably null Het
Ermp1 T C 19: 29,593,236 (GRCm39) K752R probably benign Het
Fhip1a A C 3: 85,595,754 (GRCm39) I377S probably damaging Het
Gjd2 T A 2: 113,841,587 (GRCm39) I297L probably benign Het
Gm1123 T C 9: 98,905,307 (GRCm39) M68V probably benign Het
Gm28372 C T 2: 130,248,818 (GRCm39) R59W probably damaging Het
Gm9912 A C 3: 148,891,074 (GRCm39) F20V unknown Het
Gpat2 T C 2: 127,272,816 (GRCm39) F176S possibly damaging Het
Gpr150 T C 13: 76,203,784 (GRCm39) H387R possibly damaging Het
Gpr20 T A 15: 73,568,269 (GRCm39) D40V probably damaging Het
Hrob T C 11: 102,146,422 (GRCm39) C233R probably benign Het
Jakmip3 A T 7: 138,622,633 (GRCm39) Q331L probably damaging Het
Kif5b A G 18: 6,225,647 (GRCm39) V179A probably damaging Het
Kif5b A T 18: 6,211,019 (GRCm39) probably benign Het
Krt14 A T 11: 100,095,242 (GRCm39) probably benign Het
L3mbtl3 A G 10: 26,207,798 (GRCm39) F307S unknown Het
Laptm4a T C 12: 8,984,687 (GRCm39) probably benign Het
Marveld3 T C 8: 110,674,719 (GRCm39) S366G possibly damaging Het
Mga C A 2: 119,781,676 (GRCm39) T2234K possibly damaging Het
Mkrn2os T C 6: 115,569,292 (GRCm39) N54S probably benign Het
Mras T C 9: 99,293,548 (GRCm39) I31V probably damaging Het
Myh1 A G 11: 67,110,732 (GRCm39) D1518G probably damaging Het
Myoz2 A T 3: 122,807,430 (GRCm39) Y127N possibly damaging Het
Nhlrc1 C A 13: 47,167,438 (GRCm39) W273L probably benign Het
Nol9 C T 4: 152,130,500 (GRCm39) probably benign Het
Nrxn2 T C 19: 6,559,959 (GRCm39) V1206A probably damaging Het
Or2ag1b T C 7: 106,288,540 (GRCm39) T133A probably benign Het
Or5k16 A T 16: 58,736,291 (GRCm39) F238I probably damaging Het
Or6c5 T A 10: 129,074,941 (GRCm39) F308I probably benign Het
Or6f2 T C 7: 139,756,447 (GRCm39) I138T probably benign Het
Or8g2b T A 9: 39,750,907 (GRCm39) M59K probably damaging Het
Pappa T C 4: 65,123,395 (GRCm39) probably null Het
Pfkl A G 10: 77,836,565 (GRCm39) S151P probably damaging Het
Pgbd5 C T 8: 125,111,118 (GRCm39) G191D probably damaging Het
Pikfyve T C 1: 65,292,512 (GRCm39) V1276A probably benign Het
Pla2g4c T A 7: 13,082,241 (GRCm39) Y486N probably damaging Het
Rasal2 C A 1: 157,003,502 (GRCm39) V386L probably benign Het
S1pr3 G A 13: 51,573,548 (GRCm39) R243Q probably damaging Het
Slc44a4 A G 17: 35,140,219 (GRCm39) D208G probably benign Het
Slc6a4 T C 11: 76,904,114 (GRCm39) S190P probably damaging Het
Snapc5 A T 9: 64,087,779 (GRCm39) probably null Het
Tbc1d14 C A 5: 36,728,913 (GRCm39) R151L probably damaging Het
Tecpr2 T A 12: 110,897,826 (GRCm39) probably benign Het
Tmem219 G A 7: 126,496,310 (GRCm39) P44L probably damaging Het
Ube2e1 T C 14: 18,330,951 (GRCm38) R51G probably null Het
Ugp2 T C 11: 21,303,447 (GRCm39) K53E probably benign Het
Vmn1r214 T C 13: 23,218,662 (GRCm39) I52T probably benign Het
Vps13b A G 15: 35,878,935 (GRCm39) E2978G probably damaging Het
Zfr A G 15: 12,159,741 (GRCm39) D679G probably damaging Het
Zhx3 T C 2: 160,622,634 (GRCm39) N511S probably damaging Het
Other mutations in Vmn2r124
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00988:Vmn2r124 APN 17 18,282,932 (GRCm39) missense probably benign 0.04
IGL01356:Vmn2r124 APN 17 18,293,733 (GRCm39) missense probably benign 0.08
IGL01387:Vmn2r124 APN 17 18,283,188 (GRCm39) missense probably damaging 0.98
IGL01413:Vmn2r124 APN 17 18,282,827 (GRCm39) missense probably benign 0.41
IGL01550:Vmn2r124 APN 17 18,283,617 (GRCm39) critical splice donor site probably null
IGL01762:Vmn2r124 APN 17 18,283,434 (GRCm39) missense possibly damaging 0.51
IGL02132:Vmn2r124 APN 17 18,284,491 (GRCm39) splice site probably benign
IGL02290:Vmn2r124 APN 17 18,293,597 (GRCm39) missense probably benign 0.09
IGL02370:Vmn2r124 APN 17 18,284,453 (GRCm39) missense probably benign 0.14
IGL02527:Vmn2r124 APN 17 18,286,764 (GRCm39) critical splice acceptor site probably null
PIT4280001:Vmn2r124 UTSW 17 18,283,487 (GRCm39) missense probably benign 0.22
PIT4514001:Vmn2r124 UTSW 17 18,293,974 (GRCm39) missense probably benign 0.01
R0362:Vmn2r124 UTSW 17 18,284,486 (GRCm39) critical splice donor site probably null
R0401:Vmn2r124 UTSW 17 18,284,407 (GRCm39) missense probably damaging 0.99
R0513:Vmn2r124 UTSW 17 18,293,991 (GRCm39) missense possibly damaging 0.89
R1139:Vmn2r124 UTSW 17 18,294,052 (GRCm39) missense possibly damaging 0.56
R1513:Vmn2r124 UTSW 17 18,283,535 (GRCm39) missense probably damaging 1.00
R1669:Vmn2r124 UTSW 17 18,283,206 (GRCm39) missense possibly damaging 0.94
R1710:Vmn2r124 UTSW 17 18,282,187 (GRCm39) splice site probably benign
R1852:Vmn2r124 UTSW 17 18,283,436 (GRCm39) missense probably benign
R1860:Vmn2r124 UTSW 17 18,269,759 (GRCm39) missense probably benign 0.11
R1953:Vmn2r124 UTSW 17 18,283,122 (GRCm39) missense probably benign 0.08
R2233:Vmn2r124 UTSW 17 18,269,927 (GRCm39) missense possibly damaging 0.95
R2234:Vmn2r124 UTSW 17 18,269,927 (GRCm39) missense possibly damaging 0.95
R2235:Vmn2r124 UTSW 17 18,269,927 (GRCm39) missense possibly damaging 0.95
R2397:Vmn2r124 UTSW 17 18,269,859 (GRCm39) missense possibly damaging 0.95
R2519:Vmn2r124 UTSW 17 18,294,280 (GRCm39) missense probably damaging 1.00
R3845:Vmn2r124 UTSW 17 18,293,953 (GRCm39) missense possibly damaging 0.90
R3846:Vmn2r124 UTSW 17 18,293,953 (GRCm39) missense possibly damaging 0.90
R4594:Vmn2r124 UTSW 17 18,294,231 (GRCm39) missense probably damaging 1.00
R4612:Vmn2r124 UTSW 17 18,283,284 (GRCm39) missense probably benign 0.12
R4790:Vmn2r124 UTSW 17 18,269,855 (GRCm39) missense probably damaging 1.00
R4809:Vmn2r124 UTSW 17 18,294,007 (GRCm39) missense probably benign 0.00
R5227:Vmn2r124 UTSW 17 18,269,819 (GRCm39) missense possibly damaging 0.95
R5254:Vmn2r124 UTSW 17 18,283,339 (GRCm39) missense probably benign 0.00
R5609:Vmn2r124 UTSW 17 18,294,102 (GRCm39) missense probably benign
R6145:Vmn2r124 UTSW 17 18,283,113 (GRCm39) missense probably benign 0.05
R6181:Vmn2r124 UTSW 17 18,294,019 (GRCm39) missense possibly damaging 0.93
R6271:Vmn2r124 UTSW 17 18,283,145 (GRCm39) missense probably benign 0.01
R7297:Vmn2r124 UTSW 17 18,293,835 (GRCm39) missense probably damaging 1.00
R7397:Vmn2r124 UTSW 17 18,282,947 (GRCm39) missense probably damaging 1.00
R7406:Vmn2r124 UTSW 17 18,282,306 (GRCm39) missense unknown
R7699:Vmn2r124 UTSW 17 18,293,985 (GRCm39) missense probably benign 0.00
R7859:Vmn2r124 UTSW 17 18,282,212 (GRCm39) missense probably damaging 1.00
R8121:Vmn2r124 UTSW 17 18,282,433 (GRCm39) missense probably benign
R8138:Vmn2r124 UTSW 17 18,283,610 (GRCm39) missense probably damaging 0.99
R8756:Vmn2r124 UTSW 17 18,294,094 (GRCm39) missense probably benign 0.08
R8796:Vmn2r124 UTSW 17 18,282,933 (GRCm39) missense possibly damaging 0.95
R8841:Vmn2r124 UTSW 17 18,283,299 (GRCm39) missense
R8960:Vmn2r124 UTSW 17 18,283,291 (GRCm39) nonsense probably null
R8970:Vmn2r124 UTSW 17 18,294,439 (GRCm39) missense probably benign
R9128:Vmn2r124 UTSW 17 18,294,439 (GRCm39) missense probably benign
R9566:Vmn2r124 UTSW 17 18,293,581 (GRCm39) missense probably benign 0.14
R9680:Vmn2r124 UTSW 17 18,293,758 (GRCm39) missense probably damaging 1.00
Posted On 2014-02-04