Incidental Mutation 'IGL00155:Vmn1r69'
| ID |
1535 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r69
|
| Ensembl Gene |
ENSMUSG00000091662 |
| Gene Name |
vomeronasal 1 receptor 69 |
| Synonyms |
V1re9 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.057)
|
| Stock # |
IGL00155
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
10313683-10315414 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 10313879 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 205
(N205S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154473
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163658]
[ENSMUST00000176284]
[ENSMUST00000176707]
[ENSMUST00000226160]
[ENSMUST00000226190]
[ENSMUST00000226228]
[ENSMUST00000228478]
[ENSMUST00000227853]
[ENSMUST00000228296]
[ENSMUST00000228638]
|
| AlphaFold |
Q8VIC1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163658
AA Change: N284S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000129646
Gene: ENSMUSG00000091662
AA Change: N284S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
50 |
307 |
3.3e-32 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176284
AA Change: N284S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176707
AA Change: N284S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226160
AA Change: N284S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226190
AA Change: N284S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226228
AA Change: N284S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226990
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228478
AA Change: N205S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227853
AA Change: N205S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228296
AA Change: N205S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228638
AA Change: N205S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aacs |
T |
C |
5: 125,590,235 (GRCm39) |
F498S |
probably damaging |
Het |
| Arhgap11a |
A |
G |
2: 113,664,601 (GRCm39) |
S561P |
probably benign |
Het |
| Best3 |
T |
C |
10: 116,824,632 (GRCm39) |
Y33H |
probably damaging |
Het |
| Cd209b |
T |
A |
8: 3,969,945 (GRCm39) |
|
probably benign |
Het |
| Cep152 |
A |
G |
2: 125,405,808 (GRCm39) |
S1575P |
probably benign |
Het |
| Crabp2 |
A |
G |
3: 87,859,506 (GRCm39) |
Y52C |
probably damaging |
Het |
| Crybg1 |
T |
C |
10: 43,868,505 (GRCm39) |
D1017G |
probably damaging |
Het |
| Ctnna2 |
A |
T |
6: 76,957,744 (GRCm39) |
W137R |
probably damaging |
Het |
| Cxcl9 |
T |
A |
5: 92,471,728 (GRCm39) |
H104L |
possibly damaging |
Het |
| Ddr2 |
A |
G |
1: 169,811,996 (GRCm39) |
I742T |
possibly damaging |
Het |
| Frem1 |
A |
G |
4: 82,877,626 (GRCm39) |
V223A |
possibly damaging |
Het |
| Fzd10 |
T |
A |
5: 128,678,592 (GRCm39) |
I104N |
probably damaging |
Het |
| Greb1 |
A |
G |
12: 16,761,962 (GRCm39) |
S473P |
probably damaging |
Het |
| Gtf2i |
T |
C |
5: 134,271,602 (GRCm39) |
Y873C |
probably damaging |
Het |
| Igsf6 |
T |
A |
7: 120,669,876 (GRCm39) |
K89* |
probably null |
Het |
| Ints3 |
A |
G |
3: 90,313,636 (GRCm39) |
F331L |
probably damaging |
Het |
| Kcnh3 |
A |
T |
15: 99,140,354 (GRCm39) |
H1080L |
possibly damaging |
Het |
| Mettl15 |
A |
T |
2: 108,923,521 (GRCm39) |
Y300* |
probably null |
Het |
| Mms19 |
A |
G |
19: 41,936,672 (GRCm39) |
F654L |
probably benign |
Het |
| Myc |
A |
G |
15: 61,861,669 (GRCm39) |
H425R |
probably benign |
Het |
| Ntn1 |
G |
T |
11: 68,117,445 (GRCm39) |
|
probably benign |
Het |
| Ormdl2 |
C |
A |
10: 128,655,944 (GRCm39) |
G69W |
probably damaging |
Het |
| Pdpr |
T |
C |
8: 111,828,704 (GRCm39) |
V69A |
possibly damaging |
Het |
| Rbbp6 |
T |
C |
7: 122,587,908 (GRCm39) |
I254T |
probably damaging |
Het |
| Sema6d |
A |
G |
2: 124,501,785 (GRCm39) |
R543G |
possibly damaging |
Het |
| Slc18a1 |
C |
T |
8: 69,503,998 (GRCm39) |
A314T |
probably damaging |
Het |
| Slc22a26 |
A |
G |
19: 7,760,201 (GRCm39) |
L514P |
probably damaging |
Het |
| Slc22a28 |
A |
C |
19: 8,107,567 (GRCm39) |
S167A |
possibly damaging |
Het |
| Speer1m |
A |
G |
5: 11,971,377 (GRCm39) |
S110G |
possibly damaging |
Het |
| Tchh |
A |
G |
3: 93,352,606 (GRCm39) |
E682G |
unknown |
Het |
| Thbs2 |
A |
T |
17: 14,889,097 (GRCm39) |
M1134K |
probably damaging |
Het |
| Tmem26 |
A |
G |
10: 68,611,184 (GRCm39) |
S218G |
probably damaging |
Het |
| Tmprss11c |
A |
T |
5: 86,387,254 (GRCm39) |
S208R |
probably benign |
Het |
| Tnfrsf8 |
T |
C |
4: 145,019,161 (GRCm39) |
|
probably null |
Het |
| Ush2a |
T |
C |
1: 188,596,875 (GRCm39) |
S3872P |
probably benign |
Het |
| Vmn2r54 |
T |
A |
7: 12,365,840 (GRCm39) |
|
probably benign |
Het |
| Wwtr1 |
A |
T |
3: 57,370,942 (GRCm39) |
M328K |
possibly damaging |
Het |
| Zfp64 |
G |
A |
2: 168,768,601 (GRCm39) |
S337L |
probably benign |
Het |
|
| Other mutations in Vmn1r69 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01972:Vmn1r69
|
APN |
7 |
10,314,586 (GRCm39) |
nonsense |
probably null |
|
|
IGL02339:Vmn1r69
|
APN |
7 |
10,314,645 (GRCm39) |
nonsense |
probably null |
|
|
IGL02424:Vmn1r69
|
APN |
7 |
10,314,585 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02602:Vmn1r69
|
APN |
7 |
10,313,901 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL03271:Vmn1r69
|
APN |
7 |
10,314,596 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0034:Vmn1r69
|
UTSW |
7 |
10,314,738 (GRCm39) |
intron |
probably benign |
|
|
R0052:Vmn1r69
|
UTSW |
7 |
10,314,327 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0096:Vmn1r69
|
UTSW |
7 |
10,313,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0539:Vmn1r69
|
UTSW |
7 |
10,314,874 (GRCm39) |
splice site |
probably benign |
|
|
R0604:Vmn1r69
|
UTSW |
7 |
10,314,581 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1681:Vmn1r69
|
UTSW |
7 |
10,314,179 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1884:Vmn1r69
|
UTSW |
7 |
10,314,678 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3741:Vmn1r69
|
UTSW |
7 |
10,314,069 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4655:Vmn1r69
|
UTSW |
7 |
10,314,026 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4735:Vmn1r69
|
UTSW |
7 |
10,314,926 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R4758:Vmn1r69
|
UTSW |
7 |
10,314,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5582:Vmn1r69
|
UTSW |
7 |
10,314,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5966:Vmn1r69
|
UTSW |
7 |
10,314,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5977:Vmn1r69
|
UTSW |
7 |
10,314,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6458:Vmn1r69
|
UTSW |
7 |
10,314,365 (GRCm39) |
missense |
probably benign |
|
|
R6987:Vmn1r69
|
UTSW |
7 |
10,314,491 (GRCm39) |
start codon destroyed |
probably null |
0.99 |
|
R7133:Vmn1r69
|
UTSW |
7 |
10,314,995 (GRCm39) |
intron |
probably benign |
|
|
R7532:Vmn1r69
|
UTSW |
7 |
10,314,281 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7878:Vmn1r69
|
UTSW |
7 |
10,314,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9100:Vmn1r69
|
UTSW |
7 |
10,314,064 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9558:Vmn1r69
|
UTSW |
7 |
10,314,185 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn1r69
|
UTSW |
7 |
10,314,023 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
| Posted On |
2011-07-12 |
Incidental Mutation