Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01764:Gpat2'

153640

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpat2

Ensembl Gene

ENSMUSG00000046338

Gene Name

glycerol-3-phosphate acyltransferase 2, mitochondrial

Synonyms

A530057A03Rik, Gpat2

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01764

Quality Score

Status

Chromosome

Chromosomal Location

127267119-127278012 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 127269456 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 36 (I36T)

Ref Sequence

ENSEMBL: ENSMUSP00000049619 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062211]

AlphaFold

Q14DK4

Predicted Effect

probably benign
Transcript: ENSMUST00000062211
AA Change: I36T

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000049619
Gene: ENSMUSG00000046338
AA Change: I36T

Domain	Start	End	E-Value	Type
PlsC	199	333	1.45e-11	SMART
Blast:PlsC	347	387	7e-13	BLAST
low complexity region	431	468	N/A	INTRINSIC
low complexity region	515	528	N/A	INTRINSIC
low complexity region	593	613	N/A	INTRINSIC
low complexity region	664	675	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700113H08Rik	A	T	10: 86,909,910 (GRCm39)	M1L	probably benign	Het
BC025920	T	A	10: 81,444,984 (GRCm39)	Y36N	probably damaging	Het
Cdk11b	G	A	4: 155,713,260 (GRCm39)	R112H	possibly damaging	Het
Ctu2	G	A	8: 123,206,161 (GRCm39)		probably benign	Het
Ddx56	A	C	11: 6,215,692 (GRCm39)	V219G	probably null	Het
Dnah14	T	C	1: 181,572,342 (GRCm39)	V2891A	probably benign	Het
Fbn2	G	T	18: 58,178,423 (GRCm39)	N1938K	probably damaging	Het
Fbxw20	A	G	9: 109,052,427 (GRCm39)	M302T	possibly damaging	Het
Fhdc1	G	A	3: 84,352,042 (GRCm39)	A1061V	possibly damaging	Het
Gsta5	A	T	9: 78,211,789 (GRCm39)		probably null	Het
Hmcn2	A	G	2: 31,295,642 (GRCm39)	E2617G	possibly damaging	Het
Hrob	T	C	11: 102,146,422 (GRCm39)	C233R	probably benign	Het
Krba1	C	T	6: 48,392,770 (GRCm39)	R895W	probably benign	Het
Large2	G	T	2: 92,197,531 (GRCm39)		probably benign	Het
Lrp1b	C	T	2: 40,587,454 (GRCm39)	V165M	unknown	Het
Mapk1	T	A	16: 16,801,597 (GRCm39)	M36K	possibly damaging	Het
Nf1	A	G	11: 79,275,013 (GRCm39)	T25A	probably benign	Het
Nrxn3	G	A	12: 90,171,524 (GRCm39)	V1316I	possibly damaging	Het
Pik3r4	G	A	9: 105,562,321 (GRCm39)		probably benign	Het
Plekhh1	G	T	12: 79,101,679 (GRCm39)	A250S	probably benign	Het
Polr3g	G	A	13: 81,830,238 (GRCm39)	T145M	possibly damaging	Het
Prss32	A	G	17: 24,075,085 (GRCm39)	D145G	probably damaging	Het
Rab11fip3	T	C	17: 26,287,667 (GRCm39)	K162R	probably benign	Het
Spag7	A	G	11: 70,554,933 (GRCm39)		probably benign	Het
Spata2l	T	A	8: 123,960,914 (GRCm39)	Q125L	probably benign	Het
Tlr9	G	T	9: 106,103,004 (GRCm39)	C765F	probably damaging	Het
Trip11	A	T	12: 101,850,890 (GRCm39)	I773N	probably damaging	Het
Vcan	T	G	13: 89,873,507 (GRCm39)	T116P	probably damaging	Het
Vmn2r22	C	T	6: 123,627,379 (GRCm39)		probably null	Het
Yme1l1	T	C	2: 23,052,556 (GRCm39)	I70T	probably benign	Het
Zfp938	T	A	10: 82,063,624 (GRCm39)		probably benign	Het

Other mutations in Gpat2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00326:Gpat2	APN	2	127,274,316 (GRCm39)	missense	probably benign	0.01
IGL00479:Gpat2	APN	2	127,276,381 (GRCm39)	missense	probably damaging	0.99
IGL01393:Gpat2	APN	2	127,274,571 (GRCm39)	missense	probably damaging	1.00
IGL01759:Gpat2	APN	2	127,272,816 (GRCm39)	missense	possibly damaging	0.94
IGL02631:Gpat2	APN	2	127,276,152 (GRCm39)	splice site	probably benign
IGL02657:Gpat2	APN	2	127,269,251 (GRCm39)	missense	probably benign	0.04
IGL02813:Gpat2	APN	2	127,276,375 (GRCm39)	missense	possibly damaging	0.90
IGL02873:Gpat2	APN	2	127,273,675 (GRCm39)	missense	probably benign	0.00
IGL02993:Gpat2	APN	2	127,269,486 (GRCm39)	missense	probably damaging	1.00
Hygroscopic	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
PIT4494001:Gpat2	UTSW	2	127,275,800 (GRCm39)	missense	probably benign	0.00
R0078:Gpat2	UTSW	2	127,270,169 (GRCm39)	missense	probably damaging	1.00
R0230:Gpat2	UTSW	2	127,277,765 (GRCm39)	missense	possibly damaging	0.95
R1619:Gpat2	UTSW	2	127,270,637 (GRCm39)	missense	probably benign	0.00
R1851:Gpat2	UTSW	2	127,276,739 (GRCm39)	missense	possibly damaging	0.77
R1939:Gpat2	UTSW	2	127,277,879 (GRCm39)	makesense	probably null
R2143:Gpat2	UTSW	2	127,275,682 (GRCm39)	missense	probably damaging	1.00
R2165:Gpat2	UTSW	2	127,270,211 (GRCm39)	missense	probably damaging	0.97
R2518:Gpat2	UTSW	2	127,270,211 (GRCm39)	missense	probably damaging	0.97
R3410:Gpat2	UTSW	2	127,270,211 (GRCm39)	missense	probably damaging	0.97
R3411:Gpat2	UTSW	2	127,270,211 (GRCm39)	missense	probably damaging	0.97
R3898:Gpat2	UTSW	2	127,277,018 (GRCm39)	missense	probably damaging	1.00
R4080:Gpat2	UTSW	2	127,275,542 (GRCm39)	missense	probably damaging	0.99
R4725:Gpat2	UTSW	2	127,273,902 (GRCm39)	missense	possibly damaging	0.83
R4841:Gpat2	UTSW	2	127,275,887 (GRCm39)	missense	probably benign	0.10
R5354:Gpat2	UTSW	2	127,270,643 (GRCm39)	missense	probably damaging	1.00
R5941:Gpat2	UTSW	2	127,270,195 (GRCm39)	missense	possibly damaging	0.53
R6362:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6374:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6375:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6377:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6380:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6381:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6382:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6383:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6384:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6393:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6565:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6594:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6595:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6649:Gpat2	UTSW	2	127,274,355 (GRCm39)	missense	possibly damaging	0.81
R6665:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6666:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6667:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6668:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R6669:Gpat2	UTSW	2	127,273,838 (GRCm39)	missense	possibly damaging	0.90
R7031:Gpat2	UTSW	2	127,277,395 (GRCm39)	missense	probably damaging	0.99
R7096:Gpat2	UTSW	2	127,270,209 (GRCm39)	missense	probably benign	0.02
R7307:Gpat2	UTSW	2	127,276,810 (GRCm39)	missense	probably damaging	1.00
R7313:Gpat2	UTSW	2	127,270,215 (GRCm39)	missense	probably damaging	0.99
R7365:Gpat2	UTSW	2	127,268,901 (GRCm39)	splice site	probably null
R8111:Gpat2	UTSW	2	127,275,777 (GRCm39)	missense	probably damaging	1.00
R8113:Gpat2	UTSW	2	127,273,267 (GRCm39)	missense	possibly damaging	0.52
R8729:Gpat2	UTSW	2	127,275,739 (GRCm39)	missense	probably damaging	0.99
R9010:Gpat2	UTSW	2	127,277,146 (GRCm39)	missense	probably benign	0.28
R9146:Gpat2	UTSW	2	127,273,206 (GRCm39)	missense	possibly damaging	0.58
Z1176:Gpat2	UTSW	2	127,275,728 (GRCm39)	missense	probably damaging	1.00
Z1176:Gpat2	UTSW	2	127,272,802 (GRCm39)	missense	probably benign

Posted On

2014-02-04