Incidental Mutation 'IGL01773:Olfr1355'
ID153708
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1355
Ensembl Gene ENSMUSG00000062873
Gene Nameolfactory receptor 1355
SynonymsGA_x6K02T2QGN0-2932609-2931677, MOR139-6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.088) question?
Stock #IGL01773
Quality Score
Status
Chromosome10
Chromosomal Location78875540-78882266 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 78879936 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 255 (T255A)
Ref Sequence ENSEMBL: ENSMUSP00000077517 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078414]
Predicted Effect possibly damaging
Transcript: ENSMUST00000078414
AA Change: T255A

PolyPhen 2 Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000077517
Gene: ENSMUSG00000062873
AA Change: T255A

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 3.1e-48 PFAM
Pfam:7tm_1 42 291 1.1e-20 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cacna1s C A 1: 136,118,753 H1775Q probably benign Het
Calcrl A G 2: 84,370,443 Y86H probably benign Het
Ccdc63 T C 5: 122,113,145 K401E possibly damaging Het
Col9a1 A G 1: 24,205,066 T127A probably benign Het
Cpq T A 15: 33,212,850 F5Y probably benign Het
Cuzd1 T A 7: 131,314,885 M282L probably damaging Het
Ddx10 C A 9: 53,204,130 D635Y possibly damaging Het
Ect2l T C 10: 18,161,504 D382G probably damaging Het
Ganc T C 2: 120,459,884 S901P possibly damaging Het
Gpr179 G A 11: 97,341,366 R671C probably benign Het
Isl2 T C 9: 55,544,220 L219P probably damaging Het
Mfsd13a T C 19: 46,369,294 S296P possibly damaging Het
Mtmr7 A T 8: 40,581,419 L287Q probably damaging Het
Olfr607 T G 7: 103,461,014 M60L possibly damaging Het
Olfr741 T C 14: 50,485,773 F105S probably damaging Het
Olfr945 A G 9: 39,258,534 I46T probably damaging Het
Pik3c3 T A 18: 30,277,102 F130I probably damaging Het
Rab3gap1 T A 1: 127,918,221 S277R possibly damaging Het
Rassf9 A G 10: 102,545,633 K290R probably benign Het
Rnaseh2a A T 8: 84,965,138 V136D probably damaging Het
Rnf39 C T 17: 36,945,436 S140L possibly damaging Het
Sbno2 A G 10: 80,057,831 V1212A probably damaging Het
Slc4a10 A T 2: 62,190,757 I50F probably damaging Het
Slfn5 A T 11: 82,961,331 E761V probably damaging Het
Sptlc1 A G 13: 53,377,298 Y18H probably damaging Het
Tfam A G 10: 71,236,975 M9T possibly damaging Het
Tmem186 A G 16: 8,635,977 L140P probably damaging Het
Try4 A T 6: 41,305,026 N182I probably damaging Het
Vmn1r209 C T 13: 22,806,280 C80Y probably damaging Het
Vmn2r104 A T 17: 20,040,668 S498T probably benign Het
Other mutations in Olfr1355
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01571:Olfr1355 APN 10 78879837 missense possibly damaging 0.95
IGL02707:Olfr1355 APN 10 78879925 missense probably damaging 1.00
IGL03233:Olfr1355 APN 10 78879572 nonsense probably null
R1067:Olfr1355 UTSW 10 78879683 nonsense probably null
R1201:Olfr1355 UTSW 10 78879477 missense probably benign 0.12
R1956:Olfr1355 UTSW 10 78879433 missense probably benign 0.28
R1978:Olfr1355 UTSW 10 78879280 missense probably damaging 1.00
R2014:Olfr1355 UTSW 10 78879388 missense possibly damaging 0.94
R2015:Olfr1355 UTSW 10 78879388 missense possibly damaging 0.94
R2245:Olfr1355 UTSW 10 78879931 missense probably damaging 0.98
R3725:Olfr1355 UTSW 10 78879932 nonsense probably null
R4899:Olfr1355 UTSW 10 78879207 missense probably benign 0.32
R5696:Olfr1355 UTSW 10 78880085 missense probably benign 0.02
R5982:Olfr1355 UTSW 10 78879953 nonsense probably null
R6448:Olfr1355 UTSW 10 78879682 missense possibly damaging 0.78
R7126:Olfr1355 UTSW 10 78879577 missense possibly damaging 0.50
R7385:Olfr1355 UTSW 10 78879454 missense probably damaging 0.97
R7807:Olfr1355 UTSW 10 78879209 missense probably benign
R7886:Olfr1355 UTSW 10 78879823 missense possibly damaging 0.59
R7969:Olfr1355 UTSW 10 78879823 missense possibly damaging 0.59
Z1177:Olfr1355 UTSW 10 78879156 critical splice acceptor site probably null
Z1177:Olfr1355 UTSW 10 78879559 missense possibly damaging 0.56
Posted On2014-02-04