Incidental Mutation 'IGL01773:Olfr945'
ID153709
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr945
Ensembl Gene ENSMUSG00000063380
Gene Nameolfactory receptor 945
SynonymsMOR171-20, GA_x6K02T2PVTD-32955932-32954982
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL01773
Quality Score
Status
Chromosome9
Chromosomal Location39256869-39276818 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 39258534 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 46 (I46T)
Ref Sequence ENSEMBL: ENSMUSP00000151086 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076903] [ENSMUST00000216698]
Predicted Effect probably benign
Transcript: ENSMUST00000076903
AA Change: I49T

PolyPhen 2 Score 0.418 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000076169
Gene: ENSMUSG00000063380
AA Change: I49T

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.2e-50 PFAM
Pfam:7tm_1 44 293 2.3e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216698
AA Change: I46T

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cacna1s C A 1: 136,118,753 H1775Q probably benign Het
Calcrl A G 2: 84,370,443 Y86H probably benign Het
Ccdc63 T C 5: 122,113,145 K401E possibly damaging Het
Col9a1 A G 1: 24,205,066 T127A probably benign Het
Cpq T A 15: 33,212,850 F5Y probably benign Het
Cuzd1 T A 7: 131,314,885 M282L probably damaging Het
Ddx10 C A 9: 53,204,130 D635Y possibly damaging Het
Ect2l T C 10: 18,161,504 D382G probably damaging Het
Ganc T C 2: 120,459,884 S901P possibly damaging Het
Gpr179 G A 11: 97,341,366 R671C probably benign Het
Isl2 T C 9: 55,544,220 L219P probably damaging Het
Mfsd13a T C 19: 46,369,294 S296P possibly damaging Het
Mtmr7 A T 8: 40,581,419 L287Q probably damaging Het
Olfr1355 A G 10: 78,879,936 T255A possibly damaging Het
Olfr607 T G 7: 103,461,014 M60L possibly damaging Het
Olfr741 T C 14: 50,485,773 F105S probably damaging Het
Pik3c3 T A 18: 30,277,102 F130I probably damaging Het
Rab3gap1 T A 1: 127,918,221 S277R possibly damaging Het
Rassf9 A G 10: 102,545,633 K290R probably benign Het
Rnaseh2a A T 8: 84,965,138 V136D probably damaging Het
Rnf39 C T 17: 36,945,436 S140L possibly damaging Het
Sbno2 A G 10: 80,057,831 V1212A probably damaging Het
Slc4a10 A T 2: 62,190,757 I50F probably damaging Het
Slfn5 A T 11: 82,961,331 E761V probably damaging Het
Sptlc1 A G 13: 53,377,298 Y18H probably damaging Het
Tfam A G 10: 71,236,975 M9T possibly damaging Het
Tmem186 A G 16: 8,635,977 L140P probably damaging Het
Try4 A T 6: 41,305,026 N182I probably damaging Het
Vmn1r209 C T 13: 22,806,280 C80Y probably damaging Het
Vmn2r104 A T 17: 20,040,668 S498T probably benign Het
Other mutations in Olfr945
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01640:Olfr945 APN 9 39258263 missense probably damaging 1.00
IGL02869:Olfr945 APN 9 39258224 nonsense probably null
IGL03245:Olfr945 APN 9 39257998 missense probably damaging 0.99
K3955:Olfr945 UTSW 9 39258630 missense probably damaging 1.00
R1710:Olfr945 UTSW 9 39258571 missense probably benign 0.07
R1746:Olfr945 UTSW 9 39258202 missense probably damaging 1.00
R1820:Olfr945 UTSW 9 39258399 missense possibly damaging 0.74
R3410:Olfr945 UTSW 9 39258601 missense possibly damaging 0.75
R4091:Olfr945 UTSW 9 39258034 missense possibly damaging 0.76
R4625:Olfr945 UTSW 9 39258318 missense probably damaging 1.00
R6475:Olfr945 UTSW 9 39258082 missense probably benign 0.00
R7114:Olfr945 UTSW 9 39258601 missense possibly damaging 0.75
R7500:Olfr945 UTSW 9 39258466 missense probably benign 0.03
R7545:Olfr945 UTSW 9 39258688 critical splice acceptor site probably null
R7850:Olfr945 UTSW 9 39258222 missense possibly damaging 0.94
R7933:Olfr945 UTSW 9 39258222 missense possibly damaging 0.94
Z1088:Olfr945 UTSW 9 39257871 missense probably benign 0.06
Posted On2014-02-04