Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01773:Try4'

153713

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Try4

Ensembl Gene

ENSMUSG00000054106

Gene Name

trypsin 4

Synonyms

0910001B19Rik, Td

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01773

Quality Score

Status

Chromosome

Chromosomal Location

41302269-41305532 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 41305026 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 182 (N182I)

Ref Sequence

ENSEMBL: ENSMUSP00000031913 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031913]

AlphaFold

Q9R0T7

Predicted Effect

probably damaging
Transcript: ENSMUST00000031913
AA Change: N182I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000031913
Gene: ENSMUSG00000054106
AA Change: N182I

Domain	Start	End	E-Value	Type
low complexity region	3	16	N/A	INTRINSIC
Tryp_SPc	23	239	9.72e-105	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193013

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cacna1s	C	A	1: 136,118,753 (GRCm38)	H1775Q	probably benign	Het
Calcrl	A	G	2: 84,370,443 (GRCm38)	Y86H	probably benign	Het
Ccdc63	T	C	5: 122,113,145 (GRCm38)	K401E	possibly damaging	Het
Col9a1	A	G	1: 24,205,066 (GRCm38)	T127A	probably benign	Het
Cpq	T	A	15: 33,212,850 (GRCm38)	F5Y	probably benign	Het
Cuzd1	T	A	7: 131,314,885 (GRCm38)	M282L	probably damaging	Het
Ddx10	C	A	9: 53,204,130 (GRCm38)	D635Y	possibly damaging	Het
Ect2l	T	C	10: 18,161,504 (GRCm38)	D382G	probably damaging	Het
Ganc	T	C	2: 120,459,884 (GRCm38)	S901P	possibly damaging	Het
Gpr179	G	A	11: 97,341,366 (GRCm38)	R671C	probably benign	Het
Isl2	T	C	9: 55,544,220 (GRCm38)	L219P	probably damaging	Het
Mfsd13a	T	C	19: 46,369,294 (GRCm38)	S296P	possibly damaging	Het
Mtmr7	A	T	8: 40,581,419 (GRCm38)	L287Q	probably damaging	Het
Olfr1355	A	G	10: 78,879,936 (GRCm38)	T255A	possibly damaging	Het
Olfr607	T	G	7: 103,461,014 (GRCm38)	M60L	possibly damaging	Het
Olfr741	T	C	14: 50,485,773 (GRCm38)	F105S	probably damaging	Het
Olfr945	A	G	9: 39,258,534 (GRCm38)	I46T	probably damaging	Het
Pik3c3	T	A	18: 30,277,102 (GRCm38)	F130I	probably damaging	Het
Rab3gap1	T	A	1: 127,918,221 (GRCm38)	S277R	possibly damaging	Het
Rassf9	A	G	10: 102,545,633 (GRCm38)	K290R	probably benign	Het
Rnaseh2a	A	T	8: 84,965,138 (GRCm38)	V136D	probably damaging	Het
Rnf39	C	T	17: 36,945,436 (GRCm38)	S140L	possibly damaging	Het
Sbno2	A	G	10: 80,057,831 (GRCm38)	V1212A	probably damaging	Het
Slc4a10	A	T	2: 62,190,757 (GRCm38)	I50F	probably damaging	Het
Slfn5	A	T	11: 82,961,331 (GRCm38)	E761V	probably damaging	Het
Sptlc1	A	G	13: 53,377,298 (GRCm38)	Y18H	probably damaging	Het
Tfam	A	G	10: 71,236,975 (GRCm38)	M9T	possibly damaging	Het
Tmem186	A	G	16: 8,635,977 (GRCm38)	L140P	probably damaging	Het
Vmn1r209	C	T	13: 22,806,280 (GRCm38)	C80Y	probably damaging	Het
Vmn2r104	A	T	17: 20,040,668 (GRCm38)	S498T	probably benign	Het

Other mutations in Try4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02216:Try4	APN	6	41,305,031 (GRCm38)	missense	probably benign
R0537:Try4	UTSW	6	41,304,362 (GRCm38)	missense	probably benign
R0731:Try4	UTSW	6	41,304,367 (GRCm38)	missense	probably benign	0.01
R1113:Try4	UTSW	6	41,305,374 (GRCm38)	missense	possibly damaging	0.90
R1833:Try4	UTSW	6	41,303,431 (GRCm38)	missense	probably damaging	0.98
R2246:Try4	UTSW	6	41,305,472 (GRCm38)	missense	possibly damaging	0.80
R4131:Try4	UTSW	6	41,305,401 (GRCm38)	nonsense	probably null
R4414:Try4	UTSW	6	41,304,971 (GRCm38)	missense	possibly damaging	0.84
R5457:Try4	UTSW	6	41,303,421 (GRCm38)	missense	probably damaging	1.00
R5707:Try4	UTSW	6	41,305,043 (GRCm38)	missense	possibly damaging	0.65
R6023:Try4	UTSW	6	41,303,421 (GRCm38)	missense	probably damaging	1.00
R7131:Try4	UTSW	6	41,304,403 (GRCm38)	missense	probably benign	0.03
R7783:Try4	UTSW	6	41,302,295 (GRCm38)	missense	possibly damaging	0.96
R8051:Try4	UTSW	6	41,305,062 (GRCm38)	missense	probably damaging	0.99
R9320:Try4	UTSW	6	41,305,074 (GRCm38)	critical splice donor site	probably null
R9730:Try4	UTSW	6	41,305,062 (GRCm38)	missense	probably damaging	1.00
RF007:Try4	UTSW	6	41,305,363 (GRCm38)	missense	probably damaging	1.00

Posted On

2014-02-04