Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01773:Try4'

153713

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Try4

Ensembl Gene

ENSMUSG00000054106

Gene Name

trypsin 4

Synonyms

0910001B19Rik, Td

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01773

Quality Score

Status

Chromosome

Chromosomal Location

41279206-41282467 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 41281960 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 182 (N182I)

Ref Sequence

ENSEMBL: ENSMUSP00000031913 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031913]

AlphaFold

Q9R0T7

Predicted Effect

probably damaging
Transcript: ENSMUST00000031913
AA Change: N182I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000031913
Gene: ENSMUSG00000054106
AA Change: N182I

Domain	Start	End	E-Value	Type
low complexity region	3	16	N/A	INTRINSIC
Tryp_SPc	23	239	9.72e-105	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193013

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cacna1s	C	A	1: 136,046,491 (GRCm39)	H1775Q	probably benign	Het
Calcrl	A	G	2: 84,200,787 (GRCm39)	Y86H	probably benign	Het
Ccdc63	T	C	5: 122,251,208 (GRCm39)	K401E	possibly damaging	Het
Col9a1	A	G	1: 24,244,147 (GRCm39)	T127A	probably benign	Het
Cpq	T	A	15: 33,212,996 (GRCm39)	F5Y	probably benign	Het
Cuzd1	T	A	7: 130,916,614 (GRCm39)	M282L	probably damaging	Het
Ddx10	C	A	9: 53,115,430 (GRCm39)	D635Y	possibly damaging	Het
Ect2l	T	C	10: 18,037,252 (GRCm39)	D382G	probably damaging	Het
Ganc	T	C	2: 120,290,365 (GRCm39)	S901P	possibly damaging	Het
Gpr179	G	A	11: 97,232,192 (GRCm39)	R671C	probably benign	Het
Isl2	T	C	9: 55,451,504 (GRCm39)	L219P	probably damaging	Het
Mfsd13a	T	C	19: 46,357,733 (GRCm39)	S296P	possibly damaging	Het
Mtmr7	A	T	8: 41,034,461 (GRCm39)	L287Q	probably damaging	Het
Or11g25	T	C	14: 50,723,230 (GRCm39)	F105S	probably damaging	Het
Or52d13	T	G	7: 103,110,221 (GRCm39)	M60L	possibly damaging	Het
Or7a39	A	G	10: 78,715,770 (GRCm39)	T255A	possibly damaging	Het
Or8g28	A	G	9: 39,169,830 (GRCm39)	I46T	probably damaging	Het
Pik3c3	T	A	18: 30,410,155 (GRCm39)	F130I	probably damaging	Het
Rab3gap1	T	A	1: 127,845,958 (GRCm39)	S277R	possibly damaging	Het
Rassf9	A	G	10: 102,381,494 (GRCm39)	K290R	probably benign	Het
Rnaseh2a	A	T	8: 85,691,767 (GRCm39)	V136D	probably damaging	Het
Rnf39	C	T	17: 37,256,328 (GRCm39)	S140L	possibly damaging	Het
Sbno2	A	G	10: 79,893,665 (GRCm39)	V1212A	probably damaging	Het
Slc4a10	A	T	2: 62,021,101 (GRCm39)	I50F	probably damaging	Het
Slfn5	A	T	11: 82,852,157 (GRCm39)	E761V	probably damaging	Het
Sptlc1	A	G	13: 53,531,334 (GRCm39)	Y18H	probably damaging	Het
Tfam	A	G	10: 71,072,805 (GRCm39)	M9T	possibly damaging	Het
Tmem186	A	G	16: 8,453,841 (GRCm39)	L140P	probably damaging	Het
Vmn1r209	C	T	13: 22,990,450 (GRCm39)	C80Y	probably damaging	Het
Vmn2r104	A	T	17: 20,260,930 (GRCm39)	S498T	probably benign	Het

Other mutations in Try4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02216:Try4	APN	6	41,281,965 (GRCm39)	missense	probably benign
R0537:Try4	UTSW	6	41,281,296 (GRCm39)	missense	probably benign
R0731:Try4	UTSW	6	41,281,301 (GRCm39)	missense	probably benign	0.01
R1113:Try4	UTSW	6	41,282,308 (GRCm39)	missense	possibly damaging	0.90
R1833:Try4	UTSW	6	41,280,365 (GRCm39)	missense	probably damaging	0.98
R2246:Try4	UTSW	6	41,282,406 (GRCm39)	missense	possibly damaging	0.80
R4131:Try4	UTSW	6	41,282,335 (GRCm39)	nonsense	probably null
R4414:Try4	UTSW	6	41,281,905 (GRCm39)	missense	possibly damaging	0.84
R5457:Try4	UTSW	6	41,280,355 (GRCm39)	missense	probably damaging	1.00
R5707:Try4	UTSW	6	41,281,977 (GRCm39)	missense	possibly damaging	0.65
R6023:Try4	UTSW	6	41,280,355 (GRCm39)	missense	probably damaging	1.00
R7131:Try4	UTSW	6	41,281,337 (GRCm39)	missense	probably benign	0.03
R7783:Try4	UTSW	6	41,279,229 (GRCm39)	missense	possibly damaging	0.96
R8051:Try4	UTSW	6	41,281,996 (GRCm39)	missense	probably damaging	0.99
R9320:Try4	UTSW	6	41,282,008 (GRCm39)	critical splice donor site	probably null
R9730:Try4	UTSW	6	41,281,996 (GRCm39)	missense	probably damaging	1.00
RF007:Try4	UTSW	6	41,282,297 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-02-04