Incidental Mutation 'IGL01778:Olfr320'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr320
Ensembl Gene ENSMUSG00000107711
Gene Nameolfactory receptor 320
SynonymsGA_x6K02T2NKPP-730312-729392, GA_x6K02T2NKPP-733777-732813, MOR285-4, MOR285-5, Olfr320, Olfr321-ps1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.195) question?
Stock #IGL01778
Quality Score
Chromosomal Location58681099-58686233 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 58684269 bp
Amino Acid Change Tyrosine to Cysteine at position 132 (Y132C)
Ref Sequence ENSEMBL: ENSMUSP00000150051 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000204718] [ENSMUST00000214662]
Predicted Effect probably damaging
Transcript: ENSMUST00000082307
AA Change: Y132C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000080924
Gene: ENSMUSG00000061344
AA Change: Y132C

Pfam:7tm_4 31 306 8.4e-45 PFAM
Pfam:7tm_1 41 290 1.1e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122047
Predicted Effect probably damaging
Transcript: ENSMUST00000204718
AA Change: Y132C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000145531
Gene: ENSMUSG00000107711
AA Change: Y132C

Pfam:7tm_4 31 306 8.4e-45 PFAM
Pfam:7tm_1 41 290 1.1e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214662
AA Change: Y132C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actrt2 T C 4: 154,666,705 K325E probably benign Het
Arc C T 15: 74,672,355 M6I probably benign Het
Atp7b A T 8: 21,994,828 D1404E probably benign Het
BC030867 T C 11: 102,255,596 C233R probably benign Het
Cdk5rap1 T A 2: 154,366,036 N156I probably damaging Het
Ctsa T C 2: 164,834,310 probably benign Het
Depdc1b T G 13: 108,362,327 N181K probably benign Het
Epg5 T C 18: 78,019,274 V1994A probably damaging Het
Epyc T A 10: 97,681,237 C312* probably null Het
Erv3 T A 2: 131,855,957 R161* probably null Het
Fhdc1 G A 3: 84,444,735 A1061V possibly damaging Het
Gfra3 T C 18: 34,691,591 T280A possibly damaging Het
Gldn A T 9: 54,334,492 probably null Het
Gm6768 T C 12: 119,262,496 noncoding transcript Het
Gtf3c4 G A 2: 28,835,088 R211C probably damaging Het
Hsh2d A G 8: 72,193,507 D16G probably damaging Het
Klk15 T A 7: 43,938,838 M190K probably damaging Het
Klri1 A G 6: 129,717,047 S26P possibly damaging Het
Krt78 T A 15: 101,950,967 D265V probably damaging Het
Lgr5 A C 10: 115,462,702 I355S probably damaging Het
Lig3 T A 11: 82,794,541 V595D probably damaging Het
Map2k6 A C 11: 110,512,869 probably benign Het
Mdm4 A G 1: 132,994,547 S286P probably benign Het
Pofut1 T A 2: 153,248,528 M114K probably damaging Het
Rdh13 C T 7: 4,430,389 probably null Het
Reg3g T A 6: 78,466,833 I131F probably benign Het
Slc26a4 C T 12: 31,528,854 probably benign Het
Slc8a2 T A 7: 16,158,893 F827I probably damaging Het
Slfn9 A T 11: 82,987,374 C310S probably damaging Het
Sypl A G 12: 32,975,642 Y235C probably damaging Het
Trav7-4 A T 14: 53,461,641 T82S possibly damaging Het
Trim28 T A 7: 13,030,702 V782D probably damaging Het
Ttn G A 2: 76,744,898 T25217M probably damaging Het
Usp6nl A G 2: 6,427,570 T260A possibly damaging Het
Vmn2r54 A T 7: 12,632,082 N308K probably benign Het
Xdh T C 17: 73,900,280 E986G probably benign Het
Zfp770 T C 2: 114,196,238 D450G probably damaging Het
Zw10 T G 9: 49,069,615 S438R probably benign Het
Other mutations in Olfr320
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02293:Olfr320 APN 11 58684170 missense probably benign 0.01
IGL03001:Olfr320 APN 11 58683876 start codon destroyed probably null 1.00
IGL03039:Olfr320 APN 11 58684011 missense probably damaging 0.98
R0064:Olfr320 UTSW 11 58684475 missense probably benign 0.00
R1506:Olfr320 UTSW 11 58684188 missense probably benign 0.13
R4255:Olfr320 UTSW 11 58683965 missense probably damaging 1.00
R4345:Olfr320 UTSW 11 58683945 missense possibly damaging 0.63
R4646:Olfr320 UTSW 11 58684730 missense probably damaging 0.99
R4951:Olfr320 UTSW 11 58684763 missense probably damaging 0.98
R5591:Olfr320 UTSW 11 58684125 missense probably benign 0.36
R6244:Olfr320 UTSW 11 58684004 missense possibly damaging 0.53
R6325:Olfr320 UTSW 11 58684528 nonsense probably null
R7894:Olfr320 UTSW 11 58684674 missense possibly damaging 0.94
Posted On2014-02-04