Incidental Mutation 'IGL01785:Vmn1r31'
| ID |
153779 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r31
|
| Ensembl Gene |
ENSMUSG00000115404 |
| Gene Name |
vomeronasal 1 receptor 31 |
| Synonyms |
Gm6709 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.135)
|
| Stock # |
IGL01785
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
58448952-58449863 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 58449709 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Arginine
at position 3
(M3R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135282
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176023]
[ENSMUST00000176147]
[ENSMUST00000176177]
[ENSMUST00000177318]
[ENSMUST00000226390]
[ENSMUST00000228586]
|
| AlphaFold |
H3BKW5 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000176023
AA Change: M3R
PolyPhen 2
Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000135252
Gene: ENSMUSG00000115404
AA Change: M3R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
1 |
58 |
1.9e-14 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000176147
AA Change: M3R
PolyPhen 2
Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000135282
Gene: ENSMUSG00000115404
AA Change: M3R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
1 |
58 |
1.9e-14 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000135472
Gene: ENSMUSG00000093379
AA Change: M52R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
4.7e-56 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177318
AA Change: M52R
PolyPhen 2
Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000135555
Gene: ENSMUSG00000115404
AA Change: M52R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
107 |
1.9e-18 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000204999
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226390
AA Change: M52R
PolyPhen 2
Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228586
AA Change: M52R
PolyPhen 2
Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb4 |
T |
A |
5: 8,965,058 (GRCm39) |
Y309* |
probably null |
Het |
| Abhd18 |
G |
A |
3: 40,860,339 (GRCm39) |
R42Q |
probably damaging |
Het |
| Ano3 |
T |
A |
2: 110,513,060 (GRCm39) |
Q645L |
probably damaging |
Het |
| Clasp1 |
T |
A |
1: 118,425,466 (GRCm39) |
L272Q |
possibly damaging |
Het |
| Clec1b |
A |
G |
6: 129,380,525 (GRCm39) |
D115G |
probably damaging |
Het |
| Clec2e |
A |
T |
6: 129,070,364 (GRCm39) |
|
probably benign |
Het |
| Corin |
T |
C |
5: 72,497,219 (GRCm39) |
N532S |
probably damaging |
Het |
| Csn1s2b |
A |
G |
5: 87,957,772 (GRCm39) |
K2R |
possibly damaging |
Het |
| Mcm8 |
A |
G |
2: 132,669,868 (GRCm39) |
D314G |
probably benign |
Het |
| Mga |
T |
A |
2: 119,733,393 (GRCm39) |
D80E |
probably damaging |
Het |
| Msh4 |
A |
G |
3: 153,563,144 (GRCm39) |
L744P |
probably damaging |
Het |
| Myof |
A |
T |
19: 37,968,871 (GRCm39) |
L348* |
probably null |
Het |
| Or12j3 |
T |
A |
7: 139,953,038 (GRCm39) |
M162L |
probably benign |
Het |
| Or6z1 |
T |
C |
7: 6,504,899 (GRCm39) |
I109V |
probably benign |
Het |
| Otud3 |
T |
C |
4: 138,624,208 (GRCm39) |
D278G |
probably benign |
Het |
| Pdpr |
C |
A |
8: 111,856,288 (GRCm39) |
H670Q |
probably damaging |
Het |
| Phf21b |
C |
A |
15: 84,692,262 (GRCm39) |
|
probably benign |
Het |
| Polr3a |
G |
A |
14: 24,534,188 (GRCm39) |
Q106* |
probably null |
Het |
| Ptprm |
G |
T |
17: 66,992,618 (GRCm39) |
N1366K |
probably damaging |
Het |
| Slc10a5 |
G |
A |
3: 10,400,259 (GRCm39) |
P134S |
probably benign |
Het |
| Slc30a9 |
A |
G |
5: 67,503,581 (GRCm39) |
|
probably benign |
Het |
| Stat6 |
T |
A |
10: 127,493,096 (GRCm39) |
V576D |
probably damaging |
Het |
| Tmem132d |
T |
C |
5: 128,061,379 (GRCm39) |
I408V |
probably benign |
Het |
| Tmem50a |
T |
C |
4: 134,625,758 (GRCm39) |
E153G |
probably damaging |
Het |
| Tmod4 |
A |
G |
3: 95,032,929 (GRCm39) |
T22A |
probably benign |
Het |
| Tmprss7 |
C |
T |
16: 45,500,997 (GRCm39) |
G268D |
probably damaging |
Het |
| Tor1a |
A |
G |
2: 30,853,715 (GRCm39) |
|
probably null |
Het |
| Trarg1 |
G |
A |
11: 76,571,292 (GRCm39) |
V103I |
probably benign |
Het |
| Ttc29 |
T |
C |
8: 79,008,970 (GRCm39) |
L280P |
probably damaging |
Het |
| Usp20 |
A |
G |
2: 30,907,175 (GRCm39) |
E594G |
probably benign |
Het |
|
| Other mutations in Vmn1r31 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01326:Vmn1r31
|
APN |
6 |
58,449,784 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01386:Vmn1r31
|
APN |
6 |
58,449,587 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL02527:Vmn1r31
|
APN |
6 |
58,449,778 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4791001:Vmn1r31
|
UTSW |
6 |
58,449,028 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0107:Vmn1r31
|
UTSW |
6 |
58,449,728 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1250:Vmn1r31
|
UTSW |
6 |
58,449,643 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1616:Vmn1r31
|
UTSW |
6 |
58,449,043 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1883:Vmn1r31
|
UTSW |
6 |
58,449,029 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1884:Vmn1r31
|
UTSW |
6 |
58,449,029 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2942:Vmn1r31
|
UTSW |
6 |
58,449,583 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4589:Vmn1r31
|
UTSW |
6 |
58,449,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4672:Vmn1r31
|
UTSW |
6 |
58,449,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4676:Vmn1r31
|
UTSW |
6 |
58,448,998 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4702:Vmn1r31
|
UTSW |
6 |
58,448,953 (GRCm39) |
makesense |
probably null |
|
|
R4703:Vmn1r31
|
UTSW |
6 |
58,448,953 (GRCm39) |
makesense |
probably null |
|
|
R4705:Vmn1r31
|
UTSW |
6 |
58,448,953 (GRCm39) |
makesense |
probably null |
|
|
R6341:Vmn1r31
|
UTSW |
6 |
58,448,995 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6549:Vmn1r31
|
UTSW |
6 |
58,449,648 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7238:Vmn1r31
|
UTSW |
6 |
58,449,858 (GRCm39) |
missense |
|
|
|
R7609:Vmn1r31
|
UTSW |
6 |
58,449,455 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8438:Vmn1r31
|
UTSW |
6 |
58,449,646 (GRCm39) |
missense |
|
|
|
R8936:Vmn1r31
|
UTSW |
6 |
58,449,083 (GRCm39) |
missense |
unknown |
|
|
R9103:Vmn1r31
|
UTSW |
6 |
58,449,073 (GRCm39) |
missense |
unknown |
|
|
Z1176:Vmn1r31
|
UTSW |
6 |
58,449,376 (GRCm39) |
missense |
unknown |
|
|
| Posted On |
2014-02-04 |
Incidental Mutation