Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01771:Slc35f3'

153835

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slc35f3

Ensembl Gene

ENSMUSG00000057060

Gene Name

solute carrier family 35, member F3

Synonyms

B230375D17Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.160) question?

Stock #

IGL01771

Quality Score

Status

Chromosome

Chromosomal Location

126865734-127122717 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 127115951 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 293 (Y293H)

Ref Sequence

ENSEMBL: ENSMUSP00000104390 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108759]

AlphaFold

Q1LZI2

Predicted Effect

probably benign
Transcript: ENSMUST00000108759
AA Change: Y293H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000104390
Gene: ENSMUSG00000057060
AA Change: Y293H

Domain	Start	End	E-Value	Type
low complexity region	25	49	N/A	INTRINSIC
Pfam:EamA	67	223	3.2e-7	PFAM
Pfam:SLC35F	145	374	3.2e-6	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Capn10	T	A	1: 92,868,087 (GRCm39)	W185R	probably damaging	Het
Frmd8	A	G	19: 5,919,603 (GRCm39)	L148P	probably damaging	Het
Gk5	T	C	9: 96,059,488 (GRCm39)	C447R	probably damaging	Het
Hip1r	T	A	5: 124,137,606 (GRCm39)	V704D	possibly damaging	Het
Kcnj10	C	A	1: 172,197,150 (GRCm39)	H221Q	probably benign	Het
Klk1b8	A	T	7: 43,604,290 (GRCm39)	I253L	probably damaging	Het
Or10aa4-ps1	T	C	1: 173,878,887 (GRCm39)		probably benign	Het
Or1ad8	A	G	11: 50,898,593 (GRCm39)	T265A	probably benign	Het
Or1e29	A	T	11: 73,667,490 (GRCm39)	I221N	probably damaging	Het
Or5ac22	T	C	16: 59,134,891 (GRCm39)	N293S	probably damaging	Het
Or8k40	C	T	2: 86,584,626 (GRCm39)	C152Y	probably benign	Het
Pdp2	A	T	8: 105,320,754 (GRCm39)	Y201F	probably benign	Het
Ppfia1	A	T	7: 144,036,094 (GRCm39)	I1112K	probably benign	Het
Ppwd1	A	G	13: 104,353,624 (GRCm39)	I378T	probably damaging	Het
Rhbdd1	T	A	1: 82,355,313 (GRCm39)	D248E	probably benign	Het
Sec14l5	T	C	16: 4,996,494 (GRCm39)		probably null	Het
Sel1l3	T	G	5: 53,279,183 (GRCm39)	D960A	probably damaging	Het
Wwc1	A	G	11: 35,744,185 (GRCm39)		probably null	Het
Zan	T	C	5: 137,391,330 (GRCm39)	N4718S	unknown	Het
Zfyve16	T	C	13: 92,658,680 (GRCm39)	I410M	probably benign	Het

Other mutations in Slc35f3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00687:Slc35f3	APN	8	127,108,903 (GRCm39)	missense	probably benign	0.02
IGL00956:Slc35f3	APN	8	127,108,963 (GRCm39)	missense	probably damaging	1.00
IGL01105:Slc35f3	APN	8	127,025,553 (GRCm39)	missense	probably damaging	1.00
IGL01710:Slc35f3	APN	8	127,115,900 (GRCm39)	missense	probably benign	0.00
IGL02254:Slc35f3	APN	8	127,115,862 (GRCm39)	missense	probably damaging	1.00
IGL02610:Slc35f3	APN	8	127,047,956 (GRCm39)	missense	probably damaging	1.00
R1666:Slc35f3	UTSW	8	127,115,960 (GRCm39)	missense	probably damaging	0.98
R2510:Slc35f3	UTSW	8	127,025,445 (GRCm39)	start gained	probably benign
R2520:Slc35f3	UTSW	8	127,121,312 (GRCm39)	missense	possibly damaging	0.81
R3807:Slc35f3	UTSW	8	127,115,978 (GRCm39)	missense	probably damaging	1.00
R4644:Slc35f3	UTSW	8	127,047,809 (GRCm39)	missense	possibly damaging	0.87
R4675:Slc35f3	UTSW	8	127,047,935 (GRCm39)	nonsense	probably null
R4976:Slc35f3	UTSW	8	127,116,020 (GRCm39)	splice site	probably null
R5037:Slc35f3	UTSW	8	127,116,011 (GRCm39)	missense	probably damaging	0.99
R5225:Slc35f3	UTSW	8	127,117,846 (GRCm39)	missense	probably damaging	0.98
R5259:Slc35f3	UTSW	8	127,115,872 (GRCm39)	missense	probably damaging	1.00
R5856:Slc35f3	UTSW	8	127,047,819 (GRCm39)	missense	probably benign	0.07
R5925:Slc35f3	UTSW	8	127,115,946 (GRCm39)	missense	probably benign	0.24
R6254:Slc35f3	UTSW	8	127,047,833 (GRCm39)	missense	possibly damaging	0.96
R6748:Slc35f3	UTSW	8	127,121,377 (GRCm39)	nonsense	probably null
R6785:Slc35f3	UTSW	8	127,121,198 (GRCm39)	missense	probably benign	0.02
R7002:Slc35f3	UTSW	8	127,115,773 (GRCm39)	critical splice acceptor site	unknown
R7291:Slc35f3	UTSW	8	127,121,297 (GRCm39)	missense	probably benign	0.02
R7411:Slc35f3	UTSW	8	127,115,777 (GRCm39)	critical splice acceptor site	probably benign
R7456:Slc35f3	UTSW	8	127,115,779 (GRCm39)	critical splice acceptor site	unknown
R7790:Slc35f3	UTSW	8	127,115,777 (GRCm39)	critical splice acceptor site	probably benign
R7852:Slc35f3	UTSW	8	127,121,219 (GRCm39)	missense	probably damaging	1.00
R8000:Slc35f3	UTSW	8	127,047,812 (GRCm39)	missense	probably benign
R8277:Slc35f3	UTSW	8	127,115,925 (GRCm39)	missense	possibly damaging	0.88
R8827:Slc35f3	UTSW	8	127,115,780 (GRCm39)	critical splice acceptor site	probably benign
R8983:Slc35f3	UTSW	8	127,115,775 (GRCm39)	critical splice acceptor site	probably benign
R9205:Slc35f3	UTSW	8	127,115,928 (GRCm39)	missense	probably damaging	0.96
R9355:Slc35f3	UTSW	8	127,108,967 (GRCm39)	missense	probably damaging	0.97
R9475:Slc35f3	UTSW	8	127,108,993 (GRCm39)	missense	probably damaging	1.00
R9492:Slc35f3	UTSW	8	127,048,026 (GRCm39)	missense	probably damaging	1.00
R9714:Slc35f3	UTSW	8	127,115,781 (GRCm39)	critical splice acceptor site	probably benign
R9729:Slc35f3	UTSW	8	127,115,777 (GRCm39)	critical splice acceptor site	probably benign
R9769:Slc35f3	UTSW	8	127,121,336 (GRCm39)	missense	probably damaging	0.99
X0067:Slc35f3	UTSW	8	127,109,062 (GRCm39)	missense	probably damaging	0.99

Posted On

2014-02-04