Incidental Mutation 'R0033:Zfp64'
ID 15384
Institutional Source Beutler Lab
Gene Symbol Zfp64
Ensembl Gene ENSMUSG00000027551
Gene Name zinc finger protein 64
Synonyms
MMRRC Submission 038327-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.828) question?
Stock # R0033 (G1)
Quality Score
Status Validated
Chromosome 2
Chromosomal Location 168735251-168797507 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 168767635 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 659 (I659N)
Ref Sequence ENSEMBL: ENSMUSP00000085285 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087971] [ENSMUST00000109162]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000087971
AA Change: I659N

PolyPhen 2 Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000085285
Gene: ENSMUSG00000027551
AA Change: I659N

DomainStartEndE-ValueType
ZnF_C2H2 31 51 5.54e1 SMART
low complexity region 71 93 N/A INTRINSIC
ZnF_C2H2 142 167 1.68e1 SMART
ZnF_C2H2 173 195 2.24e-3 SMART
ZnF_C2H2 201 223 1.58e-3 SMART
ZnF_C2H2 229 251 2.24e-3 SMART
ZnF_C2H2 257 279 3.89e-3 SMART
ZnF_C2H2 285 308 6.32e-3 SMART
ZnF_C2H2 313 335 2.05e-2 SMART
ZnF_C2H2 341 363 1.95e-3 SMART
ZnF_C2H2 369 392 1.36e-2 SMART
ZnF_C2H2 423 445 1.47e-3 SMART
low complexity region 503 522 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000109162
SMART Domains Protein: ENSMUSP00000104790
Gene: ENSMUSG00000027551

DomainStartEndE-ValueType
ZnF_C2H2 31 51 5.54e1 SMART
low complexity region 71 93 N/A INTRINSIC
ZnF_C2H2 142 167 1.68e1 SMART
ZnF_C2H2 173 195 2.24e-3 SMART
ZnF_C2H2 201 223 1.58e-3 SMART
ZnF_C2H2 229 251 2.24e-3 SMART
ZnF_C2H2 297 322 5.2e0 SMART
ZnF_C2H2 328 350 4.17e-3 SMART
ZnF_C2H2 356 378 6.78e-3 SMART
ZnF_C2H2 384 406 2.24e-3 SMART
ZnF_C2H2 412 434 1.79e-2 SMART
ZnF_C2H2 440 463 9.58e-3 SMART
ZnF_C2H2 465 487 3.78e-1 SMART
ZnF_C2H2 493 515 3.89e-3 SMART
ZnF_C2H2 521 544 1.92e-2 SMART
ZnF_C2H2 578 600 5.34e-1 SMART
Meta Mutation Damage Score 0.2230 question?
Coding Region Coverage
  • 1x: 80.0%
  • 3x: 71.7%
  • 10x: 49.2%
  • 20x: 29.7%
Validation Efficiency 96% (74/77)
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agr3 C T 12: 35,978,329 (GRCm39) T14M possibly damaging Het
Aldh9a1 T C 1: 167,184,140 (GRCm39) S212P probably damaging Het
Ank2 T A 3: 126,898,397 (GRCm39) probably benign Het
Cdkn3 C A 14: 47,006,329 (GRCm39) Y141* probably null Het
Ceacam12 T G 7: 17,803,385 (GRCm39) probably benign Het
Celf1 T C 2: 90,831,798 (GRCm39) probably benign Het
Col6a3 A G 1: 90,729,967 (GRCm39) S1780P probably damaging Het
Cpxm2 T C 7: 131,663,886 (GRCm39) I346V possibly damaging Het
Csf3r A G 4: 125,925,677 (GRCm39) T151A probably benign Het
Ctss G A 3: 95,452,888 (GRCm39) probably benign Het
Erp44 T C 4: 48,241,289 (GRCm39) probably benign Het
Hibch A G 1: 52,944,610 (GRCm39) K296R probably null Het
Katnip T G 7: 125,360,999 (GRCm39) V103G possibly damaging Het
Kirrel3 A G 9: 34,912,259 (GRCm39) I208V probably benign Het
Lrrc8a G T 2: 30,145,357 (GRCm39) C57F probably damaging Het
Ltbp1 A G 17: 75,583,504 (GRCm39) N435D possibly damaging Het
Myo16 A T 8: 10,420,955 (GRCm39) Y265F probably damaging Het
Nckap5 A G 1: 125,867,979 (GRCm39) probably benign Het
Nlrp12 A C 7: 3,289,037 (GRCm39) S492A probably damaging Het
Pwwp2b A T 7: 138,834,844 (GRCm39) D95V possibly damaging Het
Rarg T A 15: 102,147,270 (GRCm39) I372F probably damaging Het
Snrnp200 T C 2: 127,079,983 (GRCm39) I1920T probably damaging Het
Sv2b A G 7: 74,767,489 (GRCm39) F636L probably benign Het
Thra G A 11: 98,655,178 (GRCm39) V353I probably benign Het
Tm7sf2 A G 19: 6,116,452 (GRCm39) probably benign Het
Tmx4 A T 2: 134,442,918 (GRCm39) probably null Het
Tnfrsf12a A G 17: 23,895,119 (GRCm39) probably null Het
Uba5 T A 9: 103,931,347 (GRCm39) T241S probably benign Het
Zfp420 A G 7: 29,573,987 (GRCm39) D69G probably benign Het
Other mutations in Zfp64
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Zfp64 APN 2 168,768,601 (GRCm39) missense probably benign 0.06
IGL01479:Zfp64 APN 2 168,793,599 (GRCm39) missense probably damaging 1.00
IGL02320:Zfp64 APN 2 168,768,118 (GRCm39) missense probably damaging 0.98
IGL03411:Zfp64 APN 2 168,793,462 (GRCm39) splice site probably null
PIT4362001:Zfp64 UTSW 2 168,767,735 (GRCm39) missense probably benign 0.23
R0033:Zfp64 UTSW 2 168,767,635 (GRCm39) missense possibly damaging 0.94
R0230:Zfp64 UTSW 2 168,754,150 (GRCm39) splice site probably benign
R0325:Zfp64 UTSW 2 168,767,960 (GRCm39) missense probably benign 0.00
R0689:Zfp64 UTSW 2 168,777,121 (GRCm39) splice site probably benign
R1741:Zfp64 UTSW 2 168,768,238 (GRCm39) missense probably benign 0.05
R2054:Zfp64 UTSW 2 168,767,728 (GRCm39) missense probably damaging 1.00
R2133:Zfp64 UTSW 2 168,782,663 (GRCm39) missense probably damaging 1.00
R2254:Zfp64 UTSW 2 168,768,662 (GRCm39) missense probably damaging 0.96
R4093:Zfp64 UTSW 2 168,767,855 (GRCm39) missense probably benign 0.00
R4094:Zfp64 UTSW 2 168,767,855 (GRCm39) missense probably benign 0.00
R4257:Zfp64 UTSW 2 168,768,298 (GRCm39) missense probably damaging 1.00
R4630:Zfp64 UTSW 2 168,768,463 (GRCm39) missense possibly damaging 0.94
R4642:Zfp64 UTSW 2 168,776,851 (GRCm39) missense probably benign 0.22
R4817:Zfp64 UTSW 2 168,768,032 (GRCm39) missense probably benign
R4880:Zfp64 UTSW 2 168,736,297 (GRCm39) missense probably damaging 1.00
R5051:Zfp64 UTSW 2 168,768,304 (GRCm39) missense probably damaging 0.98
R5155:Zfp64 UTSW 2 168,748,885 (GRCm39) missense probably benign 0.17
R5562:Zfp64 UTSW 2 168,767,642 (GRCm39) missense probably benign 0.00
R5619:Zfp64 UTSW 2 168,741,734 (GRCm39) missense probably damaging 0.99
R5619:Zfp64 UTSW 2 168,741,735 (GRCm39) missense probably damaging 0.97
R5620:Zfp64 UTSW 2 168,741,888 (GRCm39) missense possibly damaging 0.70
R5919:Zfp64 UTSW 2 168,768,419 (GRCm39) missense probably benign 0.05
R6156:Zfp64 UTSW 2 168,768,088 (GRCm39) missense probably benign 0.34
R6364:Zfp64 UTSW 2 168,754,186 (GRCm39) missense probably damaging 1.00
R6488:Zfp64 UTSW 2 168,777,129 (GRCm39) critical splice donor site probably null
R6512:Zfp64 UTSW 2 168,735,997 (GRCm39) missense probably benign 0.00
R6588:Zfp64 UTSW 2 168,768,827 (GRCm39) missense probably damaging 1.00
R7103:Zfp64 UTSW 2 168,768,357 (GRCm39) missense probably benign 0.00
R7313:Zfp64 UTSW 2 168,741,810 (GRCm39) missense probably damaging 1.00
R7470:Zfp64 UTSW 2 168,767,731 (GRCm39) missense probably damaging 1.00
R7529:Zfp64 UTSW 2 168,735,992 (GRCm39) missense probably benign
R7560:Zfp64 UTSW 2 168,767,585 (GRCm39) missense probably damaging 1.00
R7963:Zfp64 UTSW 2 168,793,538 (GRCm39) missense probably benign 0.32
R8037:Zfp64 UTSW 2 168,741,932 (GRCm39) missense probably damaging 1.00
R8038:Zfp64 UTSW 2 168,741,932 (GRCm39) missense probably damaging 1.00
R8825:Zfp64 UTSW 2 168,793,552 (GRCm39) missense probably benign
R8840:Zfp64 UTSW 2 168,768,635 (GRCm39) missense probably benign
R8891:Zfp64 UTSW 2 168,797,083 (GRCm39) start codon destroyed probably null 0.37
R9062:Zfp64 UTSW 2 168,767,747 (GRCm39) missense probably benign
R9592:Zfp64 UTSW 2 168,768,118 (GRCm39) missense probably damaging 1.00
R9681:Zfp64 UTSW 2 168,793,680 (GRCm39) missense probably damaging 1.00
Posted On 2012-12-17