Incidental Mutation 'IGL01771:Olfr51'
ID153847
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr51
Ensembl Gene ENSMUSG00000060918
Gene Nameolfactory receptor 51
SynonymsMOR129-3, ID7, GA_x6K02T2QP88-4431129-4430206
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.058) question?
Stock #IGL01771
Quality Score
Status
Chromosome11
Chromosomal Location51003596-51009676 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 51007766 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 265 (T265A)
Ref Sequence ENSEMBL: ENSMUSP00000151005 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076514] [ENSMUST00000213415]
Predicted Effect probably benign
Transcript: ENSMUST00000076514
AA Change: T265A

PolyPhen 2 Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000075832
Gene: ENSMUSG00000060918
AA Change: T265A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.4e-50 PFAM
Pfam:7tm_1 41 289 8.7e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213415
AA Change: T265A

PolyPhen 2 Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Capn10 T A 1: 92,940,365 W185R probably damaging Het
Frmd8 A G 19: 5,869,575 L148P probably damaging Het
Gk5 T C 9: 96,177,435 C447R probably damaging Het
Hip1r T A 5: 123,999,543 V704D possibly damaging Het
Kcnj10 C A 1: 172,369,583 H221Q probably benign Het
Klk1b8 A T 7: 43,954,866 I253L probably damaging Het
Olfr1090 C T 2: 86,754,282 C152Y probably benign Het
Olfr204 T C 16: 59,314,528 N293S probably damaging Het
Olfr389 A T 11: 73,776,664 I221N probably damaging Het
Olfr431-ps1 T C 1: 174,051,321 probably benign Het
Pdp2 A T 8: 104,594,122 Y201F probably benign Het
Ppfia1 A T 7: 144,482,357 I1112K probably benign Het
Ppwd1 A G 13: 104,217,116 I378T probably damaging Het
Rhbdd1 T A 1: 82,377,592 D248E probably benign Het
Sec14l5 T C 16: 5,178,630 probably null Het
Sel1l3 T G 5: 53,121,841 D960A probably damaging Het
Slc35f3 T C 8: 126,389,212 Y293H probably benign Het
Wwc1 A G 11: 35,853,358 probably null Het
Zan T C 5: 137,393,068 N4718S unknown Het
Zfyve16 T C 13: 92,522,172 I410M probably benign Het
Other mutations in Olfr51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02729:Olfr51 APN 11 51007065 missense probably damaging 1.00
R0367:Olfr51 UTSW 11 51007077 missense probably damaging 1.00
R1675:Olfr51 UTSW 11 51007637 missense probably benign 0.01
R1716:Olfr51 UTSW 11 51007852 missense probably damaging 1.00
R1943:Olfr51 UTSW 11 51007675 missense probably benign 0.42
R3027:Olfr51 UTSW 11 51007052 missense possibly damaging 0.77
R4569:Olfr51 UTSW 11 51007554 missense possibly damaging 0.94
R5190:Olfr51 UTSW 11 51007554 missense probably damaging 0.98
R5447:Olfr51 UTSW 11 51007343 missense possibly damaging 0.66
R5560:Olfr51 UTSW 11 51007523 missense possibly damaging 0.61
R6396:Olfr51 UTSW 11 51007485 missense possibly damaging 0.46
R6943:Olfr51 UTSW 11 51007326 missense probably damaging 1.00
R7199:Olfr51 UTSW 11 51007396 nonsense probably null
R7991:Olfr51 UTSW 11 51007244 missense possibly damaging 0.48
R8118:Olfr51 UTSW 11 51007500 missense probably damaging 1.00
R8178:Olfr51 UTSW 11 51007610 missense probably damaging 1.00
R8496:Olfr51 UTSW 11 51007050 missense probably benign
Posted On2014-02-04