Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01779:Trim67'

153899

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trim67

Ensembl Gene

ENSMUSG00000036913

Gene Name

tripartite motif-containing 67

Synonyms

D130049O21Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.243) question?

Stock #

IGL01779

Quality Score

Status

Chromosome

Chromosomal Location

124793092-124834713 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 124828121 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Arginine at position 701 (G701R)

Ref Sequence

ENSEMBL: ENSMUSP00000148625 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041106] [ENSMUST00000167588] [ENSMUST00000211867]

AlphaFold

Q505D9

Predicted Effect

probably damaging
Transcript: ENSMUST00000041106
AA Change: G701R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000040601
Gene: ENSMUSG00000036913
AA Change: G701R

Domain	Start	End	E-Value	Type
RING	7	157	1.41e-4	SMART
BBOX	198	248	4.65e-5	SMART
BBOX	285	327	3.04e-9	SMART
BBC	334	460	1.18e-28	SMART
FN3	498	579	1.75e-6	SMART
Pfam:SPRY	635	755	1.3e-13	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161868

Predicted Effect

probably damaging
Transcript: ENSMUST00000167588
AA Change: G701R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000130343
Gene: ENSMUSG00000036913
AA Change: G701R

Domain	Start	End	E-Value	Type
RING	7	157	1.41e-4	SMART
BBOX	198	248	4.65e-5	SMART
BBOX	285	327	3.04e-9	SMART
BBC	334	460	1.18e-28	SMART
FN3	498	579	1.75e-6	SMART
Pfam:SPRY	633	756	3.6e-17	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000211867
AA Change: G701R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl3	A	T	5: 81,387,870	I119F	probably damaging	Het
Akt1	C	T	12: 112,657,169	G286R	probably damaging	Het
Apof	A	G	10: 128,269,477	I167V	probably benign	Het
Arhgap15	A	G	2: 44,065,045	E220G	possibly damaging	Het
Clca3a2	T	A	3: 144,819,378	Y31F	possibly damaging	Het
Clmn	T	C	12: 104,782,140	I383V	probably benign	Het
Cntnap5b	A	G	1: 99,967,339	D112G	probably damaging	Het
Col8a1	A	T	16: 57,628,363	H261Q	unknown	Het
Csmd3	A	T	15: 47,857,894	V1551D	probably benign	Het
Ddx60	G	A	8: 62,017,823	V1450M	possibly damaging	Het
Ethe1	A	T	7: 24,595,009	H79L	probably damaging	Het
Fhdc1	G	A	3: 84,444,735	A1061V	possibly damaging	Het
Gm11110	C	T	17: 57,102,087		probably benign	Het
Hs1bp3	C	T	12: 8,341,945	T349I	probably benign	Het
Ifna16	A	T	4: 88,676,645	I71N	probably damaging	Het
Il18bp	A	G	7: 102,016,795	Y59H	possibly damaging	Het
Kcnt1	T	A	2: 25,900,967	I511N	probably damaging	Het
Mlph	A	G	1: 90,942,950	M528V	probably benign	Het
Olfr646	A	G	7: 104,106,633	D118G	probably damaging	Het
Pprc1	T	A	19: 46,062,202	I52N	probably damaging	Het
Rfx1	T	A	8: 84,092,662		probably benign	Het
Rnf17	A	T	14: 56,462,063	I553F	probably benign	Het
Scaper	A	T	9: 55,892,240	H180Q	probably benign	Het
Slc26a4	C	T	12: 31,528,854		probably benign	Het
Slc30a10	A	T	1: 185,464,179	Q346L	possibly damaging	Het
Stambpl1	A	T	19: 34,240,027	H422L	possibly damaging	Het
Vipr1	T	C	9: 121,664,630	F249S	probably damaging	Het
Vmn2r117	G	T	17: 23,477,241	D397E	probably benign	Het

Other mutations in Trim67

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00817:Trim67	APN	8	124815060	splice site	probably benign
IGL01676:Trim67	APN	8	124815160	missense	possibly damaging	0.51
IGL02057:Trim67	APN	8	124823130	missense	probably benign	0.00
IGL02201:Trim67	APN	8	124794058	missense	probably benign	0.26
IGL02304:Trim67	APN	8	124825952	missense	probably damaging	1.00
R0068:Trim67	UTSW	8	124794568	missense	probably damaging	0.97
R0241:Trim67	UTSW	8	124823190	missense	probably damaging	0.99
R0319:Trim67	UTSW	8	124823227	missense	probably damaging	0.98
R0471:Trim67	UTSW	8	124794658	missense	probably benign	0.01
R1171:Trim67	UTSW	8	124829081	missense	probably damaging	0.97
R1175:Trim67	UTSW	8	124817035	missense	probably damaging	0.99
R1444:Trim67	UTSW	8	124823193	missense	probably benign	0.01
R1596:Trim67	UTSW	8	124826139	missense	probably damaging	0.97
R1706:Trim67	UTSW	8	124794421	missense	probably damaging	1.00
R4951:Trim67	UTSW	8	124794667	missense	probably benign
R5200:Trim67	UTSW	8	124824850	missense	probably damaging	0.99
R5787:Trim67	UTSW	8	124794312	nonsense	probably null
R6023:Trim67	UTSW	8	124815104	missense	probably damaging	0.99
R6290:Trim67	UTSW	8	124823179	missense	probably benign	0.00
R6536:Trim67	UTSW	8	124794342	missense	possibly damaging	0.51
R7315:Trim67	UTSW	8	124794330	missense	probably benign	0.18
R7660:Trim67	UTSW	8	124820285	missense	probably damaging	1.00
R8432:Trim67	UTSW	8	124794062	small deletion	probably benign
R8446:Trim67	UTSW	8	124793991	missense	probably damaging	0.99
R8713:Trim67	UTSW	8	124820335	missense	probably null	0.06
R8897:Trim67	UTSW	8	124825979	missense	probably benign
R9322:Trim67	UTSW	8	124823228	nonsense	probably null
R9430:Trim67	UTSW	8	124826217	missense	probably damaging	0.98
R9542:Trim67	UTSW	8	124794758	missense	possibly damaging	0.84
Z1088:Trim67	UTSW	8	124817041	missense	probably damaging	0.99

Posted On

2014-02-04