Incidental Mutation 'IGL01782:Gm10220'
ID153950
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm10220
Ensembl Gene ENSMUSG00000067698
Gene Namepredicted gene 10220
Synonyms
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.437) question?
Stock #IGL01782
Quality Score
Status
Chromosome5
Chromosomal Location26114764-26121421 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 26117023 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 217 (L217Q)
Ref Sequence ENSEMBL: ENSMUSP00000085569 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088236]
Predicted Effect probably damaging
Transcript: ENSMUST00000088236
AA Change: L217Q

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000085569
Gene: ENSMUSG00000067698
AA Change: L217Q

DomainStartEndE-ValueType
Pfam:Takusan 50 134 1.6e-25 PFAM
low complexity region 235 259 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aagab T C 9: 63,616,713 V34A probably benign Het
Acacb G T 5: 114,200,520 G764W probably damaging Het
Ankib1 A G 5: 3,727,607 C428R probably damaging Het
Card11 A G 5: 140,927,726 M1T probably null Het
Ccdc62 T A 5: 123,954,576 N541K possibly damaging Het
Cep290 C T 10: 100,545,125 Q1742* probably null Het
Cyp2c23 T C 19: 44,029,115 T25A possibly damaging Het
Dtx2 C A 5: 136,010,127 Y13* probably null Het
Dync1h1 T C 12: 110,614,940 I273T probably damaging Het
E430018J23Rik T C 7: 127,393,304 T45A probably benign Het
Etfb A G 7: 43,454,542 T134A probably damaging Het
Fig4 A C 10: 41,270,400 L182R probably benign Het
Gm4871 T G 5: 145,030,360 probably benign Het
Gm5346 T A 8: 43,626,735 T151S probably benign Het
Gm5464 T C 14: 66,869,388 probably benign Het
Lurap1 A G 4: 116,144,503 probably benign Het
Mmp17 T A 5: 129,602,141 V368E probably damaging Het
Mrpl22 T A 11: 58,171,844 probably null Het
Nisch G A 14: 31,176,639 probably benign Het
Odf4 A T 11: 68,926,633 H76Q probably damaging Het
Olfr330 T A 11: 58,529,159 M276L probably benign Het
Olfr777 C T 10: 129,269,039 V95I probably benign Het
Orc1 T C 4: 108,606,268 S661P possibly damaging Het
Otud4 T G 8: 79,673,011 F784V possibly damaging Het
Prkch A G 12: 73,759,662 D561G probably damaging Het
Pttg1ip T C 10: 77,581,929 probably null Het
Ranbp2 A G 10: 58,478,309 K1617R probably damaging Het
Rarb T G 14: 16,434,180 S333R probably damaging Het
Rps6ka2 A G 17: 7,236,124 K99E probably benign Het
Sel1l2 A T 2: 140,243,935 W542R probably damaging Het
Sema3g G T 14: 31,227,791 R643L probably damaging Het
Sltm T A 9: 70,573,641 D258E probably damaging Het
Stx18 G A 5: 38,106,611 V80I possibly damaging Het
Taar2 A T 10: 23,941,144 N194I probably damaging Het
Ube2r2 T C 4: 41,174,129 probably null Het
Unk C A 11: 116,058,379 N645K probably benign Het
Vmn1r73 A G 7: 11,756,738 K161R probably benign Het
Vps13a T C 19: 16,754,337 D137G probably damaging Het
Xrra1 A G 7: 99,875,194 T104A possibly damaging Het
Zfp410 T A 12: 84,327,274 probably benign Het
Other mutations in Gm10220
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00401:Gm10220 APN 5 26118611 missense possibly damaging 0.94
IGL03194:Gm10220 APN 5 26121233 missense probably damaging 1.00
IGL03218:Gm10220 APN 5 26118698 missense probably damaging 0.99
IGL03255:Gm10220 APN 5 26116901 missense possibly damaging 0.93
R3014:Gm10220 UTSW 5 26117828 missense probably damaging 0.99
R3883:Gm10220 UTSW 5 26116910 missense possibly damaging 0.70
R4577:Gm10220 UTSW 5 26117871 missense probably benign
R5484:Gm10220 UTSW 5 26117932 missense possibly damaging 0.59
R6358:Gm10220 UTSW 5 26120305 splice site probably null
R8300:Gm10220 UTSW 5 26117820 missense probably damaging 0.99
R8871:Gm10220 UTSW 5 26117865 missense probably benign 0.01
Posted On2014-02-04