Incidental Mutation 'IGL01768:Or7e168'
ID 153984
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7e168
Ensembl Gene ENSMUSG00000095448
Gene Name olfactory receptor family 7 subfamily E member 168
Synonyms Olfr859, GA_x6K02T2PVTD-13548326-13549255, MOR146-3, MOR146-10_p
Accession Numbers
Essential gene? Probably non essential (E-score: 0.095) question?
Stock # IGL01768
Quality Score
Status
Chromosome 9
Chromosomal Location 19719616-19720545 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 19720456 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 281 (V281M)
Ref Sequence ENSEMBL: ENSMUSP00000151076 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086480] [ENSMUST00000212540] [ENSMUST00000217280]
AlphaFold Q7TRF5
Predicted Effect possibly damaging
Transcript: ENSMUST00000086480
AA Change: V281M

PolyPhen 2 Score 0.571 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000083669
Gene: ENSMUSG00000095448
AA Change: V281M

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.2e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 304 2e-7 PFAM
Pfam:7tm_1 41 290 3.9e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000212540
AA Change: V281M

PolyPhen 2 Score 0.571 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217280
AA Change: V281M

PolyPhen 2 Score 0.571 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aifm3 T C 16: 17,324,141 (GRCm39) V567A possibly damaging Het
Arnt T C 3: 95,398,327 (GRCm39) probably benign Het
C8b G A 4: 104,644,151 (GRCm39) E273K probably benign Het
Capn5 C T 7: 97,774,480 (GRCm39) R570H probably damaging Het
Cdh9 A T 15: 16,778,311 (GRCm39) D42V possibly damaging Het
Cdk17 T C 10: 93,044,123 (GRCm39) S21P probably damaging Het
Cdkl3 T A 11: 51,916,744 (GRCm39) F291I probably damaging Het
Cfap210 A T 2: 69,612,471 (GRCm39) probably benign Het
Clmn T C 12: 104,747,978 (GRCm39) E523G probably damaging Het
Cyp4f14 A T 17: 33,126,976 (GRCm39) I318N probably damaging Het
Daam1 T A 12: 72,036,659 (GRCm39) F1068L probably benign Het
Ext2 A G 2: 93,621,455 (GRCm39) probably benign Het
F5 T A 1: 164,003,914 (GRCm39) F236L probably benign Het
Fat2 A G 11: 55,153,394 (GRCm39) V3606A probably damaging Het
Gpam G A 19: 55,075,952 (GRCm39) T220M probably benign Het
Hyal1 C A 9: 107,456,338 (GRCm39) L342I probably damaging Het
Ilvbl C A 10: 78,419,127 (GRCm39) P459T possibly damaging Het
Itga5 A G 15: 103,259,997 (GRCm39) Y632H probably benign Het
Jkampl A T 6: 73,445,899 (GRCm39) L217M possibly damaging Het
Krt73 T C 15: 101,707,291 (GRCm39) D299G probably benign Het
Lcp1 T C 14: 75,461,573 (GRCm39) V522A probably benign Het
Lmo3 A G 6: 138,393,495 (GRCm39) C53R probably damaging Het
Nsun7 T C 5: 66,436,043 (GRCm39) V305A probably benign Het
Oprm1 T C 10: 6,779,186 (GRCm39) S196P probably damaging Het
Or2y1e G A 11: 49,218,958 (GRCm39) C240Y probably damaging Het
Or4z4 A T 19: 12,076,403 (GRCm39) I200N probably damaging Het
Ovgp1 T C 3: 105,888,667 (GRCm39) probably null Het
Pcdhb20 T C 18: 37,639,768 (GRCm39) F765L possibly damaging Het
Ppp4r4 T C 12: 103,547,664 (GRCm39) V3A probably benign Het
Ruvbl1 A G 6: 88,474,253 (GRCm39) I419V probably benign Het
Scara5 T A 14: 65,927,224 (GRCm39) C40* probably null Het
Siglec1 T C 2: 130,916,314 (GRCm39) Q1212R probably benign Het
Slc31a1 G A 4: 62,306,273 (GRCm39) probably null Het
Sparc G T 11: 55,296,069 (GRCm39) N87K probably damaging Het
Tcf12 T C 9: 71,776,278 (GRCm39) probably null Het
Timm44 A T 8: 4,316,860 (GRCm39) F258I probably benign Het
Tm2d2 G T 8: 25,508,095 (GRCm39) V80L possibly damaging Het
Tpr A G 1: 150,320,199 (GRCm39) D2249G possibly damaging Het
Trim50 G T 5: 135,392,736 (GRCm39) G217V possibly damaging Het
Ugcg T C 4: 59,217,216 (GRCm39) probably null Het
Vmn2r107 A T 17: 20,565,868 (GRCm39) H61L probably benign Het
Zfp84 A G 7: 29,476,091 (GRCm39) H261R probably benign Het
Zswim2 A T 2: 83,748,301 (GRCm39) M293K probably benign Het
Other mutations in Or7e168
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00156:Or7e168 APN 9 19,719,692 (GRCm39) missense probably benign 0.09
IGL00897:Or7e168 APN 9 19,719,917 (GRCm39) missense probably damaging 0.97
IGL01132:Or7e168 APN 9 19,719,950 (GRCm39) missense probably damaging 0.97
IGL02302:Or7e168 APN 9 19,719,981 (GRCm39) missense probably damaging 0.97
IGL02377:Or7e168 APN 9 19,720,343 (GRCm39) missense probably damaging 0.99
IGL02972:Or7e168 APN 9 19,720,238 (GRCm39) missense probably damaging 0.97
R0139:Or7e168 UTSW 9 19,720,165 (GRCm39) missense probably damaging 0.99
R0367:Or7e168 UTSW 9 19,719,839 (GRCm39) missense probably damaging 0.99
R0521:Or7e168 UTSW 9 19,720,156 (GRCm39) missense probably benign 0.00
R1196:Or7e168 UTSW 9 19,719,928 (GRCm39) missense probably benign 0.00
R3742:Or7e168 UTSW 9 19,720,195 (GRCm39) missense probably benign 0.44
R5567:Or7e168 UTSW 9 19,719,674 (GRCm39) missense probably damaging 0.99
R6499:Or7e168 UTSW 9 19,719,847 (GRCm39) missense probably benign
R6501:Or7e168 UTSW 9 19,720,271 (GRCm39) missense possibly damaging 0.95
R6560:Or7e168 UTSW 9 19,720,412 (GRCm39) missense probably benign
R7291:Or7e168 UTSW 9 19,719,944 (GRCm39) missense possibly damaging 0.71
R7623:Or7e168 UTSW 9 19,720,225 (GRCm39) missense possibly damaging 0.93
R7627:Or7e168 UTSW 9 19,719,947 (GRCm39) missense probably damaging 0.99
R8680:Or7e168 UTSW 9 19,720,105 (GRCm39) missense possibly damaging 0.84
R8716:Or7e168 UTSW 9 19,720,165 (GRCm39) missense probably damaging 0.99
R8841:Or7e168 UTSW 9 19,719,885 (GRCm39) missense probably benign 0.02
R9360:Or7e168 UTSW 9 19,720,529 (GRCm39) missense possibly damaging 0.82
Z1177:Or7e168 UTSW 9 19,719,830 (GRCm39) missense probably damaging 1.00
Posted On 2014-02-04