Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01774:Olfr659'

154025

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr659

Ensembl Gene

ENSMUSG00000073922

Gene Name

olfactory receptor 659

Synonyms

GA_x6K02T2PBJ9-7298889-7299857, MOR34-4

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.108) question?

Stock #

IGL01774

Quality Score

Status

Chromosome

Chromosomal Location

104666753-104674948 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 104670942 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 80 (I80T)

Ref Sequence

ENSEMBL: ENSMUSP00000149939 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098170] [ENSMUST00000214986]

Predicted Effect

probably benign
Transcript: ENSMUST00000098170
AA Change: I80T

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000095772
Gene: ENSMUSG00000073922
AA Change: I80T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	314	5.2e-99	PFAM
Pfam:7TM_GPCR_Srsx	37	256	7.2e-9	PFAM
Pfam:7tm_1	43	296	4.7e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214986
AA Change: I80T

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	A	G	7: 120,477,835	D708G	probably damaging	Het
Abca16	T	C	7: 120,421,801		probably benign	Het
Abcc5	T	C	16: 20,378,457	D674G	probably damaging	Het
Abr	A	G	11: 76,464,299		probably benign	Het
Arfgef3	A	G	10: 18,743,615	I4T	possibly damaging	Het
Btla	A	G	16: 45,250,548	N290S	possibly damaging	Het
Catip	C	A	1: 74,368,483	R325S	probably damaging	Het
Cep120	A	G	18: 53,706,830	L786P	possibly damaging	Het
Cnot8	A	G	11: 58,115,307	I221V	probably benign	Het
Eloc	A	T	1: 16,645,789	D37E	probably benign	Het
Fabp12	A	C	3: 10,247,694	N89K	probably benign	Het
Ficd	G	T	5: 113,739,012	R416L	probably damaging	Het
Frmd3	T	C	4: 74,187,838	Y574H	probably damaging	Het
Frmd4a	T	C	2: 4,535,236		probably benign	Het
Gatc	G	A	5: 115,341,017	Q45*	probably null	Het
Gm5414	T	C	15: 101,626,975	D225G	probably benign	Het
Itpkc	G	T	7: 27,212,370	A592E	probably benign	Het
Kl	G	T	5: 150,988,483	V566L	probably benign	Het
Lpin1	T	A	12: 16,558,476	D545V	probably damaging	Het
Mtcl1	T	C	17: 66,385,885	Y483C	probably damaging	Het
Neb	C	T	2: 52,222,970	W67*	probably null	Het
Nrarp	T	C	2: 25,181,286	V59A	possibly damaging	Het
Nuf2	G	A	1: 169,506,072	T345M	probably benign	Het
Pacs2	T	A	12: 113,056,842	H278Q	probably benign	Het
Pot1a	T	C	6: 25,753,277	K420R	probably benign	Het
Rag2	A	G	2: 101,630,047	Y234C	probably damaging	Het
Ralgds	C	T	2: 28,550,542	Q88*	probably null	Het
Rictor	T	C	15: 6,769,777	S365P	probably damaging	Het
Slco1a1	G	A	6: 141,925,613	Q276*	probably null	Het
Tas2r134	C	T	2: 51,628,148	T213I	probably benign	Het
Tecpr1	A	G	5: 144,211,540	I349T	probably damaging	Het
Tnxb	T	C	17: 34,688,839	S1286P	probably damaging	Het
Trafd1	A	G	5: 121,375,050	V375A	possibly damaging	Het
Vmn2r110	T	A	17: 20,583,627	I229L	probably benign	Het
Vnn1	T	C	10: 23,900,710	Y320H	probably benign	Het
Zfp990	T	C	4: 145,536,948	V172A	probably benign	Het

Other mutations in Olfr659

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01443:Olfr659	APN	7	104671071	missense	probably damaging	1.00
IGL01640:Olfr659	APN	7	104671664	missense	probably damaging	0.96
IGL01912:Olfr659	APN	7	104671233	missense	possibly damaging	0.91
IGL02338:Olfr659	APN	7	104671681	utr 3 prime	probably benign
IGL02611:Olfr659	APN	7	104671407	missense	possibly damaging	0.91
IGL02707:Olfr659	APN	7	104670929	missense	probably damaging	0.97
R1139:Olfr659	UTSW	7	104670891	missense	probably damaging	1.00
R1283:Olfr659	UTSW	7	104670943	missense	possibly damaging	0.94
R1867:Olfr659	UTSW	7	104671317	missense	possibly damaging	0.89
R2004:Olfr659	UTSW	7	104671601	missense	possibly damaging	0.88
R2265:Olfr659	UTSW	7	104670860	missense	probably benign	0.00
R4057:Olfr659	UTSW	7	104671269	missense	probably damaging	1.00
R4519:Olfr659	UTSW	7	104670839	missense	probably damaging	1.00
R4735:Olfr659	UTSW	7	104670993	missense	probably benign
R4745:Olfr659	UTSW	7	104671504	missense	probably damaging	1.00
R4816:Olfr659	UTSW	7	104670735	missense	probably benign	0.04
R5274:Olfr659	UTSW	7	104671526	missense	probably damaging	0.99
R6299:Olfr659	UTSW	7	104670868	missense	probably benign	0.08
R6312:Olfr659	UTSW	7	104671589	missense	probably damaging	1.00
R6770:Olfr659	UTSW	7	104671518	missense	probably damaging	1.00
R7293:Olfr659	UTSW	7	104670718	missense	probably damaging	1.00
R8119:Olfr659	UTSW	7	104670854	missense	probably damaging	1.00
R8425:Olfr659	UTSW	7	104671295	missense	probably damaging	1.00
R8493:Olfr659	UTSW	7	104670815	missense	probably benign	0.13
RF004:Olfr659	UTSW	7	104671041	missense	probably damaging	0.98

Posted On

2014-02-04