Incidental Mutation 'IGL01774:Olfr659'
ID154025
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr659
Ensembl Gene ENSMUSG00000073922
Gene Nameolfactory receptor 659
SynonymsGA_x6K02T2PBJ9-7298889-7299857, MOR34-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.108) question?
Stock #IGL01774
Quality Score
Status
Chromosome7
Chromosomal Location104666753-104674948 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 104670942 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 80 (I80T)
Ref Sequence ENSEMBL: ENSMUSP00000149939 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098170] [ENSMUST00000214986]
Predicted Effect probably benign
Transcript: ENSMUST00000098170
AA Change: I80T

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000095772
Gene: ENSMUSG00000073922
AA Change: I80T

DomainStartEndE-ValueType
Pfam:7tm_4 33 314 5.2e-99 PFAM
Pfam:7TM_GPCR_Srsx 37 256 7.2e-9 PFAM
Pfam:7tm_1 43 296 4.7e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214986
AA Change: I80T

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A G 7: 120,477,835 D708G probably damaging Het
Abca16 T C 7: 120,421,801 probably benign Het
Abcc5 T C 16: 20,378,457 D674G probably damaging Het
Abr A G 11: 76,464,299 probably benign Het
Arfgef3 A G 10: 18,743,615 I4T possibly damaging Het
Btla A G 16: 45,250,548 N290S possibly damaging Het
Catip C A 1: 74,368,483 R325S probably damaging Het
Cep120 A G 18: 53,706,830 L786P possibly damaging Het
Cnot8 A G 11: 58,115,307 I221V probably benign Het
Eloc A T 1: 16,645,789 D37E probably benign Het
Fabp12 A C 3: 10,247,694 N89K probably benign Het
Ficd G T 5: 113,739,012 R416L probably damaging Het
Frmd3 T C 4: 74,187,838 Y574H probably damaging Het
Frmd4a T C 2: 4,535,236 probably benign Het
Gatc G A 5: 115,341,017 Q45* probably null Het
Gm5414 T C 15: 101,626,975 D225G probably benign Het
Itpkc G T 7: 27,212,370 A592E probably benign Het
Kl G T 5: 150,988,483 V566L probably benign Het
Lpin1 T A 12: 16,558,476 D545V probably damaging Het
Mtcl1 T C 17: 66,385,885 Y483C probably damaging Het
Neb C T 2: 52,222,970 W67* probably null Het
Nrarp T C 2: 25,181,286 V59A possibly damaging Het
Nuf2 G A 1: 169,506,072 T345M probably benign Het
Pacs2 T A 12: 113,056,842 H278Q probably benign Het
Pot1a T C 6: 25,753,277 K420R probably benign Het
Rag2 A G 2: 101,630,047 Y234C probably damaging Het
Ralgds C T 2: 28,550,542 Q88* probably null Het
Rictor T C 15: 6,769,777 S365P probably damaging Het
Slco1a1 G A 6: 141,925,613 Q276* probably null Het
Tas2r134 C T 2: 51,628,148 T213I probably benign Het
Tecpr1 A G 5: 144,211,540 I349T probably damaging Het
Tnxb T C 17: 34,688,839 S1286P probably damaging Het
Trafd1 A G 5: 121,375,050 V375A possibly damaging Het
Vmn2r110 T A 17: 20,583,627 I229L probably benign Het
Vnn1 T C 10: 23,900,710 Y320H probably benign Het
Zfp990 T C 4: 145,536,948 V172A probably benign Het
Other mutations in Olfr659
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01443:Olfr659 APN 7 104671071 missense probably damaging 1.00
IGL01640:Olfr659 APN 7 104671664 missense probably damaging 0.96
IGL01912:Olfr659 APN 7 104671233 missense possibly damaging 0.91
IGL02338:Olfr659 APN 7 104671681 utr 3 prime probably benign
IGL02611:Olfr659 APN 7 104671407 missense possibly damaging 0.91
IGL02707:Olfr659 APN 7 104670929 missense probably damaging 0.97
R1139:Olfr659 UTSW 7 104670891 missense probably damaging 1.00
R1283:Olfr659 UTSW 7 104670943 missense possibly damaging 0.94
R1867:Olfr659 UTSW 7 104671317 missense possibly damaging 0.89
R2004:Olfr659 UTSW 7 104671601 missense possibly damaging 0.88
R2265:Olfr659 UTSW 7 104670860 missense probably benign 0.00
R4057:Olfr659 UTSW 7 104671269 missense probably damaging 1.00
R4519:Olfr659 UTSW 7 104670839 missense probably damaging 1.00
R4735:Olfr659 UTSW 7 104670993 missense probably benign
R4745:Olfr659 UTSW 7 104671504 missense probably damaging 1.00
R4816:Olfr659 UTSW 7 104670735 missense probably benign 0.04
R5274:Olfr659 UTSW 7 104671526 missense probably damaging 0.99
R6299:Olfr659 UTSW 7 104670868 missense probably benign 0.08
R6312:Olfr659 UTSW 7 104671589 missense probably damaging 1.00
R6770:Olfr659 UTSW 7 104671518 missense probably damaging 1.00
R7293:Olfr659 UTSW 7 104670718 missense probably damaging 1.00
R8119:Olfr659 UTSW 7 104670854 missense probably damaging 1.00
R8425:Olfr659 UTSW 7 104671295 missense probably damaging 1.00
R8493:Olfr659 UTSW 7 104670815 missense probably benign 0.13
RF004:Olfr659 UTSW 7 104671041 missense probably damaging 0.98
Posted On2014-02-04