Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01774:Vmn2r110'

154038

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r110

Ensembl Gene

ENSMUSG00000091259

Gene Name

vomeronasal 2, receptor 110

Synonyms

EG224582

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.222) question?

Stock #

IGL01774

Quality Score

Status

Chromosome

Chromosomal Location

20573829-20596259 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20583627 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 229 (I229L)

Ref Sequence

ENSEMBL: ENSMUSP00000129347 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169559]

Predicted Effect

probably benign
Transcript: ENSMUST00000169559
AA Change: I229L

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000129347
Gene: ENSMUSG00000091259
AA Change: I229L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	3.1e-33	PFAM
Pfam:NCD3G	510	563	5.2e-22	PFAM
Pfam:7tm_3	594	831	4.2e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	A	G	7: 120,477,835	D708G	probably damaging	Het
Abca16	T	C	7: 120,421,801		probably benign	Het
Abcc5	T	C	16: 20,378,457	D674G	probably damaging	Het
Abr	A	G	11: 76,464,299		probably benign	Het
Arfgef3	A	G	10: 18,743,615	I4T	possibly damaging	Het
Btla	A	G	16: 45,250,548	N290S	possibly damaging	Het
Catip	C	A	1: 74,368,483	R325S	probably damaging	Het
Cep120	A	G	18: 53,706,830	L786P	possibly damaging	Het
Cnot8	A	G	11: 58,115,307	I221V	probably benign	Het
Eloc	A	T	1: 16,645,789	D37E	probably benign	Het
Fabp12	A	C	3: 10,247,694	N89K	probably benign	Het
Ficd	G	T	5: 113,739,012	R416L	probably damaging	Het
Frmd3	T	C	4: 74,187,838	Y574H	probably damaging	Het
Frmd4a	T	C	2: 4,535,236		probably benign	Het
Gatc	G	A	5: 115,341,017	Q45*	probably null	Het
Gm5414	T	C	15: 101,626,975	D225G	probably benign	Het
Itpkc	G	T	7: 27,212,370	A592E	probably benign	Het
Kl	G	T	5: 150,988,483	V566L	probably benign	Het
Lpin1	T	A	12: 16,558,476	D545V	probably damaging	Het
Mtcl1	T	C	17: 66,385,885	Y483C	probably damaging	Het
Neb	C	T	2: 52,222,970	W67*	probably null	Het
Nrarp	T	C	2: 25,181,286	V59A	possibly damaging	Het
Nuf2	G	A	1: 169,506,072	T345M	probably benign	Het
Olfr659	T	C	7: 104,670,942	I80T	probably benign	Het
Pacs2	T	A	12: 113,056,842	H278Q	probably benign	Het
Pot1a	T	C	6: 25,753,277	K420R	probably benign	Het
Rag2	A	G	2: 101,630,047	Y234C	probably damaging	Het
Ralgds	C	T	2: 28,550,542	Q88*	probably null	Het
Rictor	T	C	15: 6,769,777	S365P	probably damaging	Het
Slco1a1	G	A	6: 141,925,613	Q276*	probably null	Het
Tas2r134	C	T	2: 51,628,148	T213I	probably benign	Het
Tecpr1	A	G	5: 144,211,540	I349T	probably damaging	Het
Tnxb	T	C	17: 34,688,839	S1286P	probably damaging	Het
Trafd1	A	G	5: 121,375,050	V375A	possibly damaging	Het
Vnn1	T	C	10: 23,900,710	Y320H	probably benign	Het
Zfp990	T	C	4: 145,536,948	V172A	probably benign	Het

Other mutations in Vmn2r110

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01824:Vmn2r110	APN	17	20574667	missense	probably benign	0.44
IGL01879:Vmn2r110	APN	17	20573860	missense	probably benign	0.01
IGL02168:Vmn2r110	APN	17	20583800	splice site	probably benign
IGL02178:Vmn2r110	APN	17	20584444	splice site	probably null
IGL02322:Vmn2r110	APN	17	20573935	missense	probably damaging	1.00
IGL02323:Vmn2r110	APN	17	20596137	missense	probably damaging	0.98
IGL02415:Vmn2r110	APN	17	20583771	missense	probably benign	0.03
IGL02491:Vmn2r110	APN	17	20596138	missense	probably damaging	0.99
IGL02876:Vmn2r110	APN	17	20574296	missense	probably damaging	0.98
IGL03141:Vmn2r110	APN	17	20583714	missense	possibly damaging	0.79
IGL03270:Vmn2r110	APN	17	20583516	missense	probably benign	0.00
IGL03286:Vmn2r110	APN	17	20584206	missense	possibly damaging	0.95
IGL03379:Vmn2r110	APN	17	20583644	missense	probably damaging	0.99
PIT4243001:Vmn2r110	UTSW	17	20582117	missense	probably benign	0.01
R0040:Vmn2r110	UTSW	17	20596084	missense	probably benign	0.10
R0195:Vmn2r110	UTSW	17	20574055	missense	probably benign	0.31
R0716:Vmn2r110	UTSW	17	20573903	missense	probably damaging	0.99
R1199:Vmn2r110	UTSW	17	20583263	missense	probably benign	0.03
R1767:Vmn2r110	UTSW	17	20580578	missense	possibly damaging	0.83
R2212:Vmn2r110	UTSW	17	20573947	splice site	probably null
R3056:Vmn2r110	UTSW	17	20583098	missense	probably damaging	1.00
R4093:Vmn2r110	UTSW	17	20583380	missense	possibly damaging	0.83
R4418:Vmn2r110	UTSW	17	20583689	nonsense	probably null
R4598:Vmn2r110	UTSW	17	20583767	nonsense	probably null
R4754:Vmn2r110	UTSW	17	20596196	missense	probably benign	0.00
R5283:Vmn2r110	UTSW	17	20580637	missense	probably benign	0.00
R5421:Vmn2r110	UTSW	17	20583620	missense	probably damaging	1.00
R5672:Vmn2r110	UTSW	17	20596232	missense	probably benign
R5865:Vmn2r110	UTSW	17	20584295	missense	probably benign	0.00
R6642:Vmn2r110	UTSW	17	20583517	missense	possibly damaging	0.94
R6799:Vmn2r110	UTSW	17	20583536	missense	probably benign
R7167:Vmn2r110	UTSW	17	20574179	missense	probably benign	0.01
R7291:Vmn2r110	UTSW	17	20574209	missense	probably benign	0.13
R7320:Vmn2r110	UTSW	17	20596054	missense	probably benign
R7519:Vmn2r110	UTSW	17	20584262	missense	probably benign
R8089:Vmn2r110	UTSW	17	20583545	missense	probably benign	0.00
R8234:Vmn2r110	UTSW	17	20584429	missense	probably benign	0.12
R8272:Vmn2r110	UTSW	17	20596228	missense	probably damaging	0.97
R8307:Vmn2r110	UTSW	17	20583057	missense	probably benign	0.00
R8506:Vmn2r110	UTSW	17	20584365	missense	probably benign	0.00
R8516:Vmn2r110	UTSW	17	20574613	missense	probably damaging	1.00
R8555:Vmn2r110	UTSW	17	20584356	missense	probably damaging	0.97
Z1088:Vmn2r110	UTSW	17	20583680	missense	probably damaging	1.00

Posted On

2014-02-04