Incidental Mutation 'IGL01774:Fabp12'
ID154054
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fabp12
Ensembl Gene ENSMUSG00000027530
Gene Namefatty acid binding protein 12
Synonyms1700008G05Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #IGL01774
Quality Score
Status
Chromosome3
Chromosomal Location10244209-10301183 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 10247694 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Lysine at position 89 (N89K)
Ref Sequence ENSEMBL: ENSMUSP00000131101 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029043] [ENSMUST00000117917] [ENSMUST00000119761] [ENSMUST00000172126]
Predicted Effect probably benign
Transcript: ENSMUST00000029043
AA Change: N89K

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000029043
Gene: ENSMUSG00000027530
AA Change: N89K

DomainStartEndE-ValueType
Pfam:Lipocalin 6 132 1.4e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000117917
AA Change: N89K

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000112464
Gene: ENSMUSG00000027530
AA Change: N89K

DomainStartEndE-ValueType
Pfam:Lipocalin 6 132 1.4e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000119761
AA Change: N89K

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000112958
Gene: ENSMUSG00000027530
AA Change: N89K

DomainStartEndE-ValueType
Pfam:Lipocalin 6 132 1.4e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172126
AA Change: N89K

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000131101
Gene: ENSMUSG00000027530
AA Change: N89K

DomainStartEndE-ValueType
Pfam:Lipocalin 6 132 1.4e-25 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A G 7: 120,477,835 D708G probably damaging Het
Abca16 T C 7: 120,421,801 probably benign Het
Abcc5 T C 16: 20,378,457 D674G probably damaging Het
Abr A G 11: 76,464,299 probably benign Het
Arfgef3 A G 10: 18,743,615 I4T possibly damaging Het
Btla A G 16: 45,250,548 N290S possibly damaging Het
Catip C A 1: 74,368,483 R325S probably damaging Het
Cep120 A G 18: 53,706,830 L786P possibly damaging Het
Cnot8 A G 11: 58,115,307 I221V probably benign Het
Eloc A T 1: 16,645,789 D37E probably benign Het
Ficd G T 5: 113,739,012 R416L probably damaging Het
Frmd3 T C 4: 74,187,838 Y574H probably damaging Het
Frmd4a T C 2: 4,535,236 probably benign Het
Gatc G A 5: 115,341,017 Q45* probably null Het
Gm5414 T C 15: 101,626,975 D225G probably benign Het
Itpkc G T 7: 27,212,370 A592E probably benign Het
Kl G T 5: 150,988,483 V566L probably benign Het
Lpin1 T A 12: 16,558,476 D545V probably damaging Het
Mtcl1 T C 17: 66,385,885 Y483C probably damaging Het
Neb C T 2: 52,222,970 W67* probably null Het
Nrarp T C 2: 25,181,286 V59A possibly damaging Het
Nuf2 G A 1: 169,506,072 T345M probably benign Het
Olfr659 T C 7: 104,670,942 I80T probably benign Het
Pacs2 T A 12: 113,056,842 H278Q probably benign Het
Pot1a T C 6: 25,753,277 K420R probably benign Het
Rag2 A G 2: 101,630,047 Y234C probably damaging Het
Ralgds C T 2: 28,550,542 Q88* probably null Het
Rictor T C 15: 6,769,777 S365P probably damaging Het
Slco1a1 G A 6: 141,925,613 Q276* probably null Het
Tas2r134 C T 2: 51,628,148 T213I probably benign Het
Tecpr1 A G 5: 144,211,540 I349T probably damaging Het
Tnxb T C 17: 34,688,839 S1286P probably damaging Het
Trafd1 A G 5: 121,375,050 V375A possibly damaging Het
Vmn2r110 T A 17: 20,583,627 I229L probably benign Het
Vnn1 T C 10: 23,900,710 Y320H probably benign Het
Zfp990 T C 4: 145,536,948 V172A probably benign Het
Other mutations in Fabp12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00551:Fabp12 APN 3 10246055 splice site probably benign
IGL00957:Fabp12 APN 3 10250213 critical splice acceptor site probably null
IGL01822:Fabp12 APN 3 10246022 nonsense probably null
IGL02047:Fabp12 APN 3 10247718 splice site probably benign
IGL02164:Fabp12 APN 3 10246015 missense probably damaging 0.99
IGL03108:Fabp12 APN 3 10250054 missense probably benign 0.12
R0501:Fabp12 UTSW 3 10250143 missense probably benign 0.00
R0647:Fabp12 UTSW 3 10246036 missense possibly damaging 0.55
R1134:Fabp12 UTSW 3 10247671 missense probably benign 0.17
R2020:Fabp12 UTSW 3 10250149 missense probably benign 0.00
R5269:Fabp12 UTSW 3 10250107 missense probably benign 0.12
R7434:Fabp12 UTSW 3 10247678 missense probably benign 0.10
Posted On2014-02-04