Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01775:Or8g23'

154082

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or8g23

Ensembl Gene

ENSMUSG00000094182

Gene Name

olfactory receptor family 8 subfamily G member 23

Synonyms

MOR171-24, GA_x6K02T2PVTD-32756567-32755632, Olfr937

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL01775

Quality Score

Status

Chromosome

Chromosomal Location

38971025-38971960 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 38971763 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 66 (L66F)

Ref Sequence

ENSEMBL: ENSMUSP00000150274 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055567] [ENSMUST00000215049]

AlphaFold

Q9EQB4

Predicted Effect

probably damaging
Transcript: ENSMUST00000055567
AA Change: L66F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000058346
Gene: ENSMUSG00000094182
AA Change: L66F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	3.8e-49	PFAM
Pfam:7tm_1	41	290	1.7e-20	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000215049
AA Change: L66F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aatf	A	T	11: 84,361,963 (GRCm39)	L333Q	probably damaging	Het
Ablim3	A	T	18: 61,949,989 (GRCm39)		probably benign	Het
Acsl6	T	C	11: 54,236,826 (GRCm39)		probably benign	Het
Adra1b	T	A	11: 43,726,128 (GRCm39)	D263V	probably damaging	Het
Aicda	G	A	6: 122,538,012 (GRCm39)	V57M	probably damaging	Het
C2cd3	T	C	7: 100,092,638 (GRCm39)	W494R	probably damaging	Het
Ccnb1	T	C	13: 100,920,017 (GRCm39)	S165G	probably benign	Het
Cnot4	A	T	6: 35,046,411 (GRCm39)		probably benign	Het
Dph6	A	T	2: 114,348,776 (GRCm39)		probably benign	Het
Emc3	A	G	6: 113,508,296 (GRCm39)	S50P	possibly damaging	Het
Fbxo45	A	C	16: 32,052,093 (GRCm39)		probably null	Het
Gm14496	A	T	2: 181,642,125 (GRCm39)	T599S	probably benign	Het
Gspt1	T	C	16: 11,041,159 (GRCm39)	I535V	possibly damaging	Het
Hemk1	A	G	9: 107,207,995 (GRCm39)	I215T	possibly damaging	Het
Ighm	A	T	12: 113,386,087 (GRCm39)	C88S	unknown	Het
Itih2	A	C	2: 10,134,097 (GRCm39)	D38E	probably benign	Het
Lat	C	A	7: 125,967,261 (GRCm39)	V113L	probably benign	Het
Mical2	T	A	7: 111,981,269 (GRCm39)	F480L	possibly damaging	Het
Mki67	A	T	7: 135,300,005 (GRCm39)	S1676R	possibly damaging	Het
Msh2	A	T	17: 87,990,074 (GRCm39)	N254I	possibly damaging	Het
Naglu	T	C	11: 100,964,921 (GRCm39)	M336T	probably damaging	Het
Nhsl1	C	T	10: 18,400,222 (GRCm39)	R483C	probably damaging	Het
Nsmaf	C	T	4: 6,396,791 (GRCm39)	E899K	possibly damaging	Het
Nup85	T	C	11: 115,471,593 (GRCm39)	Y181H	probably damaging	Het
Or52n2	A	T	7: 104,542,499 (GRCm39)	M112K	possibly damaging	Het
Or5m5	T	C	2: 85,815,014 (GRCm39)	S277P	probably damaging	Het
Or7g35	A	T	9: 19,496,001 (GRCm39)	Q56L	probably benign	Het
P2rx3	C	T	2: 84,854,501 (GRCm39)	R91H	probably benign	Het
Plag1	T	C	4: 3,904,513 (GRCm39)	D226G	probably damaging	Het
Pofut1	T	A	2: 153,090,393 (GRCm39)	F96I	probably damaging	Het
Prim1	A	G	10: 127,865,112 (GRCm39)	N399S	probably benign	Het
Prkd3	G	T	17: 79,320,189 (GRCm39)	T51K	probably damaging	Het
Ptprc	T	C	1: 137,992,497 (GRCm39)	Y1210C	probably damaging	Het
Rbm43	A	T	2: 51,815,460 (GRCm39)	S254T	probably damaging	Het
Retsat	G	A	6: 72,584,300 (GRCm39)	R528Q	probably damaging	Het
Rlig1	A	T	10: 100,419,799 (GRCm39)	L94Q	probably benign	Het
Rps8	C	A	4: 117,012,249 (GRCm39)	R56L	probably benign	Het
Samhd1	A	T	2: 156,956,250 (GRCm39)		probably benign	Het
Sfxn1	T	C	13: 54,259,758 (GRCm39)		probably benign	Het
Stk33	T	A	7: 108,911,574 (GRCm39)	E396D	possibly damaging	Het
Tcaim	T	C	9: 122,647,890 (GRCm39)	V135A	probably damaging	Het
Thsd7b	A	G	1: 129,556,676 (GRCm39)	D421G	probably damaging	Het
Unc80	A	G	1: 66,640,215 (GRCm39)	D1374G	possibly damaging	Het
Wnk2	C	A	13: 49,224,586 (GRCm39)	D232Y	probably damaging	Het
Zfand1	T	C	3: 10,409,926 (GRCm39)	T145A	probably damaging	Het

Other mutations in Or8g23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Or8g23	APN	9	38,971,159 (GRCm39)	missense	probably benign	0.03
IGL01387:Or8g23	APN	9	38,971,617 (GRCm39)	missense	probably damaging	1.00
IGL02076:Or8g23	APN	9	38,971,881 (GRCm39)	missense	probably damaging	1.00
IGL02740:Or8g23	APN	9	38,971,585 (GRCm39)	missense	probably benign	0.22
IGL03115:Or8g23	APN	9	38,971,259 (GRCm39)	missense	probably damaging	0.99
R0121:Or8g23	UTSW	9	38,971,056 (GRCm39)	missense	probably damaging	1.00
R0908:Or8g23	UTSW	9	38,971,243 (GRCm39)	missense	probably damaging	1.00
R1559:Or8g23	UTSW	9	38,971,437 (GRCm39)	missense	probably benign	0.20
R2006:Or8g23	UTSW	9	38,971,729 (GRCm39)	missense	probably damaging	0.99
R2010:Or8g23	UTSW	9	38,971,395 (GRCm39)	missense	probably benign	0.05
R2191:Or8g23	UTSW	9	38,971,701 (GRCm39)	missense	probably benign
R3874:Or8g23	UTSW	9	38,971,470 (GRCm39)	missense	probably benign	0.00
R4970:Or8g23	UTSW	9	38,971,827 (GRCm39)	missense	probably benign	0.12
R5217:Or8g23	UTSW	9	38,971,065 (GRCm39)	missense	probably benign	0.00
R5836:Or8g23	UTSW	9	38,971,918 (GRCm39)	missense	probably benign
R5886:Or8g23	UTSW	9	38,971,678 (GRCm39)	missense	probably benign	0.00
R6109:Or8g23	UTSW	9	38,971,492 (GRCm39)	missense	probably benign	0.23
R7261:Or8g23	UTSW	9	38,971,504 (GRCm39)	missense	possibly damaging	0.64
R7328:Or8g23	UTSW	9	38,971,857 (GRCm39)	missense	probably damaging	1.00
R7345:Or8g23	UTSW	9	38,971,875 (GRCm39)	missense	probably damaging	1.00
R7419:Or8g23	UTSW	9	38,971,465 (GRCm39)	missense	probably benign	0.00
R9624:Or8g23	UTSW	9	38,971,453 (GRCm39)	missense	probably benign	0.40
X0022:Or8g23	UTSW	9	38,971,713 (GRCm39)	missense	probably benign	0.12

Posted On

2014-02-04