Incidental Mutation 'IGL01775:Tcaim'
ID 154097
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tcaim
Ensembl Gene ENSMUSG00000046603
Gene Name T cell activation inhibitor, mitochondrial
Synonyms D9Ertd402e, LOC382117
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01775
Quality Score
Status
Chromosome 9
Chromosomal Location 122634604-122665399 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 122647890 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 135 (V135A)
Ref Sequence ENSEMBL: ENSMUSP00000049759 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052740] [ENSMUST00000136274]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000052740
AA Change: V135A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000049759
Gene: ENSMUSG00000046603
AA Change: V135A

DomainStartEndE-ValueType
Pfam:DUF4460 33 144 4.2e-40 PFAM
Pfam:DUF4461 199 503 4.1e-124 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000136274
SMART Domains Protein: ENSMUSP00000120948
Gene: ENSMUSG00000046603

DomainStartEndE-ValueType
Pfam:DUF4460 31 125 2.7e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207349
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatf A T 11: 84,361,963 (GRCm39) L333Q probably damaging Het
Ablim3 A T 18: 61,949,989 (GRCm39) probably benign Het
Acsl6 T C 11: 54,236,826 (GRCm39) probably benign Het
Adra1b T A 11: 43,726,128 (GRCm39) D263V probably damaging Het
Aicda G A 6: 122,538,012 (GRCm39) V57M probably damaging Het
C2cd3 T C 7: 100,092,638 (GRCm39) W494R probably damaging Het
Ccnb1 T C 13: 100,920,017 (GRCm39) S165G probably benign Het
Cnot4 A T 6: 35,046,411 (GRCm39) probably benign Het
Dph6 A T 2: 114,348,776 (GRCm39) probably benign Het
Emc3 A G 6: 113,508,296 (GRCm39) S50P possibly damaging Het
Fbxo45 A C 16: 32,052,093 (GRCm39) probably null Het
Gm14496 A T 2: 181,642,125 (GRCm39) T599S probably benign Het
Gspt1 T C 16: 11,041,159 (GRCm39) I535V possibly damaging Het
Hemk1 A G 9: 107,207,995 (GRCm39) I215T possibly damaging Het
Ighm A T 12: 113,386,087 (GRCm39) C88S unknown Het
Itih2 A C 2: 10,134,097 (GRCm39) D38E probably benign Het
Lat C A 7: 125,967,261 (GRCm39) V113L probably benign Het
Mical2 T A 7: 111,981,269 (GRCm39) F480L possibly damaging Het
Mki67 A T 7: 135,300,005 (GRCm39) S1676R possibly damaging Het
Msh2 A T 17: 87,990,074 (GRCm39) N254I possibly damaging Het
Naglu T C 11: 100,964,921 (GRCm39) M336T probably damaging Het
Nhsl1 C T 10: 18,400,222 (GRCm39) R483C probably damaging Het
Nsmaf C T 4: 6,396,791 (GRCm39) E899K possibly damaging Het
Nup85 T C 11: 115,471,593 (GRCm39) Y181H probably damaging Het
Or52n2 A T 7: 104,542,499 (GRCm39) M112K possibly damaging Het
Or5m5 T C 2: 85,815,014 (GRCm39) S277P probably damaging Het
Or7g35 A T 9: 19,496,001 (GRCm39) Q56L probably benign Het
Or8g23 C A 9: 38,971,763 (GRCm39) L66F probably damaging Het
P2rx3 C T 2: 84,854,501 (GRCm39) R91H probably benign Het
Plag1 T C 4: 3,904,513 (GRCm39) D226G probably damaging Het
Pofut1 T A 2: 153,090,393 (GRCm39) F96I probably damaging Het
Prim1 A G 10: 127,865,112 (GRCm39) N399S probably benign Het
Prkd3 G T 17: 79,320,189 (GRCm39) T51K probably damaging Het
Ptprc T C 1: 137,992,497 (GRCm39) Y1210C probably damaging Het
Rbm43 A T 2: 51,815,460 (GRCm39) S254T probably damaging Het
Retsat G A 6: 72,584,300 (GRCm39) R528Q probably damaging Het
Rlig1 A T 10: 100,419,799 (GRCm39) L94Q probably benign Het
Rps8 C A 4: 117,012,249 (GRCm39) R56L probably benign Het
Samhd1 A T 2: 156,956,250 (GRCm39) probably benign Het
Sfxn1 T C 13: 54,259,758 (GRCm39) probably benign Het
Stk33 T A 7: 108,911,574 (GRCm39) E396D possibly damaging Het
Thsd7b A G 1: 129,556,676 (GRCm39) D421G probably damaging Het
Unc80 A G 1: 66,640,215 (GRCm39) D1374G possibly damaging Het
Wnk2 C A 13: 49,224,586 (GRCm39) D232Y probably damaging Het
Zfand1 T C 3: 10,409,926 (GRCm39) T145A probably damaging Het
Other mutations in Tcaim
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01389:Tcaim APN 9 122,643,627 (GRCm39) missense possibly damaging 0.69
R1193:Tcaim UTSW 9 122,647,895 (GRCm39) missense probably damaging 0.96
R1487:Tcaim UTSW 9 122,647,897 (GRCm39) nonsense probably null
R1592:Tcaim UTSW 9 122,647,838 (GRCm39) critical splice acceptor site probably null
R1639:Tcaim UTSW 9 122,647,838 (GRCm39) critical splice acceptor site probably null
R1642:Tcaim UTSW 9 122,647,838 (GRCm39) critical splice acceptor site probably null
R1853:Tcaim UTSW 9 122,655,271 (GRCm39) missense probably damaging 1.00
R4204:Tcaim UTSW 9 122,662,683 (GRCm39) missense probably benign 0.01
R4427:Tcaim UTSW 9 122,643,561 (GRCm39) missense probably benign 0.01
R6547:Tcaim UTSW 9 122,643,531 (GRCm39) missense probably benign 0.22
R6599:Tcaim UTSW 9 122,663,844 (GRCm39) nonsense probably null
R6906:Tcaim UTSW 9 122,663,839 (GRCm39) missense probably benign 0.01
R7158:Tcaim UTSW 9 122,648,055 (GRCm39) missense possibly damaging 0.66
R7286:Tcaim UTSW 9 122,648,092 (GRCm39) critical splice donor site probably null
R7806:Tcaim UTSW 9 122,663,995 (GRCm39) missense probably damaging 1.00
R9368:Tcaim UTSW 9 122,647,928 (GRCm39) missense probably damaging 1.00
R9376:Tcaim UTSW 9 122,655,995 (GRCm39) missense probably damaging 1.00
R9597:Tcaim UTSW 9 122,637,830 (GRCm39) critical splice acceptor site probably null
Z1088:Tcaim UTSW 9 122,662,722 (GRCm39) missense probably benign 0.00
Posted On 2014-02-04