Incidental Mutation 'IGL01777:Vmn1r40'
| ID |
154108 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r40
|
| Ensembl Gene |
ENSMUSG00000096051 |
| Gene Name |
vomeronasal 1 receptor 40 |
| Synonyms |
V1rb7 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
IGL01777
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
89688243-89692117 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 89691204 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 7
(L7P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154581
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075158]
[ENSMUST00000226925]
[ENSMUST00000227669]
[ENSMUST00000228485]
[ENSMUST00000228642]
|
| AlphaFold |
Q9EQ46 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075158
AA Change: L7P
PolyPhen 2
Score 0.377 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000074655
Gene: ENSMUSG00000096051
AA Change: L7P
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
15 |
37 |
N/A |
INTRINSIC |
|
Pfam:V1R
|
38 |
302 |
3.4e-143 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226925
AA Change: L7P
PolyPhen 2
Score 0.377 (Sensitivity: 0.90; Specificity: 0.89)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227669
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228485
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228642
AA Change: L7P
PolyPhen 2
Score 0.377 (Sensitivity: 0.90; Specificity: 0.89)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2 |
T |
C |
3: 59,932,205 (GRCm39) |
V240A |
possibly damaging |
Het |
| Aftph |
A |
T |
11: 20,676,554 (GRCm39) |
C352S |
possibly damaging |
Het |
| Cand2 |
T |
C |
6: 115,769,818 (GRCm39) |
V876A |
probably damaging |
Het |
| Ccar1 |
T |
C |
10: 62,616,356 (GRCm39) |
I125V |
possibly damaging |
Het |
| Celsr3 |
A |
T |
9: 108,713,141 (GRCm39) |
M1858L |
probably benign |
Het |
| Csmd3 |
A |
T |
15: 47,561,594 (GRCm39) |
N2134K |
probably benign |
Het |
| Dhx29 |
A |
G |
13: 113,067,406 (GRCm39) |
I96V |
probably benign |
Het |
| Dst |
A |
G |
1: 34,238,478 (GRCm39) |
T3727A |
probably benign |
Het |
| Elavl4 |
T |
A |
4: 110,063,858 (GRCm39) |
|
probably null |
Het |
| Eno2 |
C |
T |
6: 124,743,600 (GRCm39) |
G113D |
probably damaging |
Het |
| Esf1 |
A |
C |
2: 139,999,092 (GRCm39) |
|
probably null |
Het |
| Frmd4b |
T |
C |
6: 97,272,905 (GRCm39) |
D783G |
probably benign |
Het |
| Grin2a |
C |
T |
16: 9,461,994 (GRCm39) |
V713I |
probably benign |
Het |
| Impa1 |
C |
T |
3: 10,388,008 (GRCm39) |
G138D |
probably damaging |
Het |
| Kcnt2 |
A |
G |
1: 140,523,736 (GRCm39) |
T1079A |
probably benign |
Het |
| Kmt2a |
A |
G |
9: 44,760,302 (GRCm39) |
S549P |
probably damaging |
Het |
| Magoh |
C |
A |
4: 107,740,373 (GRCm39) |
Q86K |
probably benign |
Het |
| Moxd1 |
C |
A |
10: 24,128,494 (GRCm39) |
T182K |
probably benign |
Het |
| Or5p55 |
A |
G |
7: 107,566,709 (GRCm39) |
Y35C |
probably damaging |
Het |
| Pramel25 |
T |
G |
4: 143,521,688 (GRCm39) |
C435G |
possibly damaging |
Het |
| Rab3b |
A |
T |
4: 108,786,607 (GRCm39) |
Q119L |
probably damaging |
Het |
| Snap47 |
T |
A |
11: 59,312,477 (GRCm39) |
|
probably null |
Het |
| Taar3 |
A |
G |
10: 23,825,903 (GRCm39) |
R150G |
probably benign |
Het |
| Tas2r102 |
C |
T |
6: 132,739,815 (GRCm39) |
T241I |
probably damaging |
Het |
| Tas2r114 |
C |
T |
6: 131,666,664 (GRCm39) |
W121* |
probably null |
Het |
| Trak1 |
G |
A |
9: 121,260,626 (GRCm39) |
|
probably null |
Het |
| Ubn1 |
T |
C |
16: 4,890,013 (GRCm39) |
V426A |
possibly damaging |
Het |
| Vmn2r43 |
T |
C |
7: 8,258,272 (GRCm39) |
I314V |
probably damaging |
Het |
| Vrtn |
T |
G |
12: 84,695,696 (GRCm39) |
S149A |
probably benign |
Het |
|
| Other mutations in Vmn1r40 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01099:Vmn1r40
|
APN |
6 |
89,691,578 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01432:Vmn1r40
|
APN |
6 |
89,691,201 (GRCm39) |
missense |
probably benign |
|
|
IGL01834:Vmn1r40
|
APN |
6 |
89,691,554 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL01908:Vmn1r40
|
APN |
6 |
89,691,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01908:Vmn1r40
|
APN |
6 |
89,691,291 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01999:Vmn1r40
|
APN |
6 |
89,691,948 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02728:Vmn1r40
|
APN |
6 |
89,691,998 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03169:Vmn1r40
|
APN |
6 |
89,692,005 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0448:Vmn1r40
|
UTSW |
6 |
89,691,642 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0971:Vmn1r40
|
UTSW |
6 |
89,691,272 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1208:Vmn1r40
|
UTSW |
6 |
89,691,326 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1208:Vmn1r40
|
UTSW |
6 |
89,691,326 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1448:Vmn1r40
|
UTSW |
6 |
89,691,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1739:Vmn1r40
|
UTSW |
6 |
89,691,297 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2170:Vmn1r40
|
UTSW |
6 |
89,691,957 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3151:Vmn1r40
|
UTSW |
6 |
89,691,548 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3804:Vmn1r40
|
UTSW |
6 |
89,691,991 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5098:Vmn1r40
|
UTSW |
6 |
89,691,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6015:Vmn1r40
|
UTSW |
6 |
89,691,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7216:Vmn1r40
|
UTSW |
6 |
89,691,606 (GRCm39) |
missense |
not run |
|
|
R7555:Vmn1r40
|
UTSW |
6 |
89,692,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7591:Vmn1r40
|
UTSW |
6 |
89,691,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9056:Vmn1r40
|
UTSW |
6 |
89,691,198 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9286:Vmn1r40
|
UTSW |
6 |
89,692,079 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9344:Vmn1r40
|
UTSW |
6 |
89,691,235 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9449:Vmn1r40
|
UTSW |
6 |
89,691,854 (GRCm39) |
missense |
probably benign |
0.39 |
|
| Posted On |
2014-02-04 |
Incidental Mutation