Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01777:Cand2'

154128

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cand2

Ensembl Gene

ENSMUSG00000030319

Gene Name

cullin associated and neddylation dissociated 2 (putative)

Synonyms

Tp120b, 2210404G23Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01777

Quality Score

Status

Chromosome

Chromosomal Location

115751518-115782516 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 115769818 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 876 (V876A)

Ref Sequence

ENSEMBL: ENSMUSP00000075377 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075995]

AlphaFold

Q6ZQ73

Predicted Effect

probably damaging
Transcript: ENSMUST00000075995
AA Change: V876A

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000075377
Gene: ENSMUSG00000030319
AA Change: V876A

Domain	Start	End	E-Value	Type
low complexity region	325	347	N/A	INTRINSIC
low complexity region	536	548	N/A	INTRINSIC
low complexity region	553	562	N/A	INTRINSIC
low complexity region	665	686	N/A	INTRINSIC
low complexity region	736	748	N/A	INTRINSIC
Pfam:HEAT	861	890	4.4e-5	PFAM
Pfam:TIP120	1044	1209	6e-64	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl2	T	C	3: 59,932,205 (GRCm39)	V240A	possibly damaging	Het
Aftph	A	T	11: 20,676,554 (GRCm39)	C352S	possibly damaging	Het
Ccar1	T	C	10: 62,616,356 (GRCm39)	I125V	possibly damaging	Het
Celsr3	A	T	9: 108,713,141 (GRCm39)	M1858L	probably benign	Het
Csmd3	A	T	15: 47,561,594 (GRCm39)	N2134K	probably benign	Het
Dhx29	A	G	13: 113,067,406 (GRCm39)	I96V	probably benign	Het
Dst	A	G	1: 34,238,478 (GRCm39)	T3727A	probably benign	Het
Elavl4	T	A	4: 110,063,858 (GRCm39)		probably null	Het
Eno2	C	T	6: 124,743,600 (GRCm39)	G113D	probably damaging	Het
Esf1	A	C	2: 139,999,092 (GRCm39)		probably null	Het
Frmd4b	T	C	6: 97,272,905 (GRCm39)	D783G	probably benign	Het
Grin2a	C	T	16: 9,461,994 (GRCm39)	V713I	probably benign	Het
Impa1	C	T	3: 10,388,008 (GRCm39)	G138D	probably damaging	Het
Kcnt2	A	G	1: 140,523,736 (GRCm39)	T1079A	probably benign	Het
Kmt2a	A	G	9: 44,760,302 (GRCm39)	S549P	probably damaging	Het
Magoh	C	A	4: 107,740,373 (GRCm39)	Q86K	probably benign	Het
Moxd1	C	A	10: 24,128,494 (GRCm39)	T182K	probably benign	Het
Or5p55	A	G	7: 107,566,709 (GRCm39)	Y35C	probably damaging	Het
Pramel25	T	G	4: 143,521,688 (GRCm39)	C435G	possibly damaging	Het
Rab3b	A	T	4: 108,786,607 (GRCm39)	Q119L	probably damaging	Het
Snap47	T	A	11: 59,312,477 (GRCm39)		probably null	Het
Taar3	A	G	10: 23,825,903 (GRCm39)	R150G	probably benign	Het
Tas2r102	C	T	6: 132,739,815 (GRCm39)	T241I	probably damaging	Het
Tas2r114	C	T	6: 131,666,664 (GRCm39)	W121*	probably null	Het
Trak1	G	A	9: 121,260,626 (GRCm39)		probably null	Het
Ubn1	T	C	16: 4,890,013 (GRCm39)	V426A	possibly damaging	Het
Vmn1r40	T	C	6: 89,691,204 (GRCm39)	L7P	probably benign	Het
Vmn2r43	T	C	7: 8,258,272 (GRCm39)	I314V	probably damaging	Het
Vrtn	T	G	12: 84,695,696 (GRCm39)	S149A	probably benign	Het

Other mutations in Cand2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01323:Cand2	APN	6	115,762,086 (GRCm39)	missense	probably benign
IGL01329:Cand2	APN	6	115,759,755 (GRCm39)	missense	probably benign	0.43
IGL02008:Cand2	APN	6	115,780,599 (GRCm39)	missense	probably damaging	1.00
IGL02185:Cand2	APN	6	115,766,471 (GRCm39)	missense	probably benign	0.01
IGL02219:Cand2	APN	6	115,780,773 (GRCm39)	missense	probably damaging	1.00
IGL02240:Cand2	APN	6	115,780,623 (GRCm39)	missense	probably damaging	1.00
IGL02329:Cand2	APN	6	115,766,568 (GRCm39)	missense	probably damaging	1.00
IGL02396:Cand2	APN	6	115,768,149 (GRCm39)	splice site	probably benign
IGL02893:Cand2	APN	6	115,768,921 (GRCm39)	missense	probably damaging	1.00
IGL03161:Cand2	APN	6	115,769,698 (GRCm39)	missense	probably benign	0.45
IGL03170:Cand2	APN	6	115,774,861 (GRCm39)	missense	probably damaging	1.00
IGL03257:Cand2	APN	6	115,776,944 (GRCm39)	missense	possibly damaging	0.80
succor	UTSW	6	115,768,153 (GRCm39)	missense	probably damaging	1.00
R0196:Cand2	UTSW	6	115,766,463 (GRCm39)	missense	probably damaging	1.00
R0390:Cand2	UTSW	6	115,751,614 (GRCm39)	missense	possibly damaging	0.90
R0534:Cand2	UTSW	6	115,764,197 (GRCm39)	missense	probably damaging	0.96
R0630:Cand2	UTSW	6	115,780,766 (GRCm39)	missense	probably damaging	1.00
R0631:Cand2	UTSW	6	115,780,766 (GRCm39)	missense	probably damaging	1.00
R0662:Cand2	UTSW	6	115,764,171 (GRCm39)	missense	probably benign	0.00
R0671:Cand2	UTSW	6	115,780,766 (GRCm39)	missense	probably damaging	1.00
R0708:Cand2	UTSW	6	115,780,766 (GRCm39)	missense	probably damaging	1.00
R0849:Cand2	UTSW	6	115,769,352 (GRCm39)	missense	probably damaging	1.00
R1992:Cand2	UTSW	6	115,762,093 (GRCm39)	missense	possibly damaging	0.88
R3428:Cand2	UTSW	6	115,766,668 (GRCm39)	missense	probably benign
R3773:Cand2	UTSW	6	115,762,178 (GRCm39)	missense	probably damaging	0.96
R4329:Cand2	UTSW	6	115,776,949 (GRCm39)	missense	possibly damaging	0.64
R4489:Cand2	UTSW	6	115,766,427 (GRCm39)	missense	probably damaging	1.00
R4553:Cand2	UTSW	6	115,769,172 (GRCm39)	missense	probably damaging	1.00
R4577:Cand2	UTSW	6	115,768,220 (GRCm39)	missense	probably damaging	1.00
R4634:Cand2	UTSW	6	115,774,948 (GRCm39)	missense	probably damaging	1.00
R4850:Cand2	UTSW	6	115,778,909 (GRCm39)	missense	probably benign	0.14
R5155:Cand2	UTSW	6	115,769,219 (GRCm39)	missense	probably benign	0.42
R5190:Cand2	UTSW	6	115,766,474 (GRCm39)	missense	probably damaging	1.00
R5378:Cand2	UTSW	6	115,778,912 (GRCm39)	missense	probably benign	0.00
R5407:Cand2	UTSW	6	115,762,161 (GRCm39)	missense	possibly damaging	0.76
R5698:Cand2	UTSW	6	115,768,704 (GRCm39)	missense	probably damaging	1.00
R5701:Cand2	UTSW	6	115,774,893 (GRCm39)	missense	probably damaging	0.99
R6172:Cand2	UTSW	6	115,768,271 (GRCm39)	missense	probably benign	0.00
R6763:Cand2	UTSW	6	115,776,930 (GRCm39)	missense	probably benign	0.00
R6920:Cand2	UTSW	6	115,768,250 (GRCm39)	missense	possibly damaging	0.93
R7229:Cand2	UTSW	6	115,768,153 (GRCm39)	missense	probably damaging	1.00
R7520:Cand2	UTSW	6	115,762,212 (GRCm39)	nonsense	probably null
R8183:Cand2	UTSW	6	115,768,879 (GRCm39)	missense	probably benign	0.14
R8698:Cand2	UTSW	6	115,763,852 (GRCm39)	missense	probably damaging	1.00
R8755:Cand2	UTSW	6	115,769,941 (GRCm39)	missense	probably damaging	1.00
R8795:Cand2	UTSW	6	115,763,889 (GRCm39)	missense	probably benign	0.01
R8900:Cand2	UTSW	6	115,757,894 (GRCm39)	missense	probably benign	0.00
R9072:Cand2	UTSW	6	115,769,490 (GRCm39)	missense	probably damaging	0.99
R9242:Cand2	UTSW	6	115,768,923 (GRCm39)	missense	probably benign	0.27
R9262:Cand2	UTSW	6	115,759,730 (GRCm39)	missense	probably benign	0.27
R9547:Cand2	UTSW	6	115,759,757 (GRCm39)	missense	probably benign	0.00
R9676:Cand2	UTSW	6	115,769,122 (GRCm39)	missense	probably benign	0.26

Posted On

2014-02-04