Incidental Mutation 'IGL01783:Or4c11'
ID 154184
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4c11
Ensembl Gene ENSMUSG00000062757
Gene Name olfactory receptor family 4 subfamily C member 11
Synonyms GA_x6K02T2Q125-50339974-50340609, Olfr1207, Olfr1206, MOR230-3, GA_x6K02T2Q125-50338497-50339264
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # IGL01783
Quality Score
Status
Chromosome 2
Chromosomal Location 88694951-88695874 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 88695186 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 79 (L79P)
Ref Sequence ENSEMBL: ENSMUSP00000149929 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077302] [ENSMUST00000216950]
AlphaFold A2ATJ9
Predicted Effect probably damaging
Transcript: ENSMUST00000077302
AA Change: L79P

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000076532
Gene: ENSMUSG00000062757
AA Change: L79P

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 3.2e-48 PFAM
Pfam:7tm_1 39 285 1.4e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216950
AA Change: L79P

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd13 T C 8: 10,037,900 (GRCm39) Y166H possibly damaging Het
Abi3bp G A 16: 56,353,332 (GRCm39) probably null Het
Actrt3 T C 3: 30,652,624 (GRCm39) T157A probably benign Het
Adam26b T C 8: 43,974,798 (GRCm39) K68R probably benign Het
Adgrg7 A G 16: 56,568,282 (GRCm39) probably null Het
Ano6 T C 15: 95,860,143 (GRCm39) I755T possibly damaging Het
Basp1 T C 15: 25,364,953 (GRCm39) N15D unknown Het
Bod1l T C 5: 41,966,055 (GRCm39) N2670S probably benign Het
Btbd3 T A 2: 138,125,656 (GRCm39) I280N probably damaging Het
Cdh16 T A 8: 105,344,488 (GRCm39) Y17F probably damaging Het
Clmp G T 9: 40,693,703 (GRCm39) G307W possibly damaging Het
Clrn2 C A 5: 45,617,503 (GRCm39) Q125K probably benign Het
Ctnna3 C T 10: 63,656,248 (GRCm39) A276V possibly damaging Het
Dram2 A T 3: 106,480,972 (GRCm39) T172S possibly damaging Het
Dync2h1 G A 9: 7,118,822 (GRCm39) probably benign Het
Ezr T C 17: 7,009,888 (GRCm39) probably benign Het
Gbe1 T A 16: 70,275,257 (GRCm39) D352E probably damaging Het
Gbe1 T C 16: 70,198,743 (GRCm39) probably null Het
Gpr18 T A 14: 122,149,789 (GRCm39) M79L probably benign Het
Gss T C 2: 155,413,479 (GRCm39) Y196C probably damaging Het
Gtpbp1 T C 15: 79,600,398 (GRCm39) S444P probably damaging Het
Hecw1 C T 13: 14,452,878 (GRCm39) R712K probably damaging Het
Helz2 T G 2: 180,874,674 (GRCm39) D1940A probably damaging Het
Hmcn1 A T 1: 150,491,051 (GRCm39) V4166E possibly damaging Het
Klkb1 T C 8: 45,729,428 (GRCm39) Y297C probably damaging Het
Krt75 T A 15: 101,473,364 (GRCm39) I537F probably benign Het
Lrp1b T A 2: 41,202,584 (GRCm39) T1176S probably damaging Het
Nid2 T C 14: 19,818,745 (GRCm39) L413P probably benign Het
Or10ag57 T A 2: 87,218,187 (GRCm39) M46K possibly damaging Het
Or10ag57 G T 2: 87,218,182 (GRCm39) L44F probably benign Het
Or5t7 A G 2: 86,507,425 (GRCm39) V84A probably benign Het
Piwil1 A G 5: 128,820,890 (GRCm39) N272D probably benign Het
Ppfia3 T C 7: 45,009,481 (GRCm39) probably null Het
Prkg1 A G 19: 30,602,089 (GRCm39) V389A probably damaging Het
Sema3a C A 5: 13,611,767 (GRCm39) S344R probably damaging Het
Serpina3j T C 12: 104,284,750 (GRCm39) L309P probably damaging Het
Slc15a1 A G 14: 121,708,688 (GRCm39) probably null Het
Sp8 G T 12: 118,812,759 (GRCm39) A205S probably benign Het
Speer4a1 T A 5: 26,240,045 (GRCm39) Q235L possibly damaging Het
St6gal1 A G 16: 23,140,305 (GRCm39) T159A probably benign Het
Tbrg1 G T 9: 37,565,596 (GRCm39) P119T possibly damaging Het
Tmem59l T C 8: 70,939,874 (GRCm39) T32A probably damaging Het
Trmt13 G A 3: 116,376,561 (GRCm39) R277* probably null Het
Zfp316 A G 5: 143,248,631 (GRCm39) F205S unknown Het
Zfp418 G T 7: 7,184,448 (GRCm39) W137L possibly damaging Het
Zp3r A T 1: 130,526,603 (GRCm39) V200D possibly damaging Het
Other mutations in Or4c11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01410:Or4c11 APN 2 88,695,864 (GRCm39) missense probably benign 0.00
IGL01415:Or4c11 APN 2 88,695,864 (GRCm39) missense probably benign 0.00
PIT4812001:Or4c11 UTSW 2 88,695,314 (GRCm39) missense probably benign 0.27
R0437:Or4c11 UTSW 2 88,695,229 (GRCm39) missense probably benign 0.01
R0561:Or4c11 UTSW 2 88,695,024 (GRCm39) missense possibly damaging 0.68
R0669:Or4c11 UTSW 2 88,695,272 (GRCm39) missense probably benign
R0835:Or4c11 UTSW 2 88,695,345 (GRCm39) missense probably benign
R0987:Or4c11 UTSW 2 88,695,527 (GRCm39) missense probably benign 0.00
R1271:Or4c11 UTSW 2 88,695,475 (GRCm39) nonsense probably null
R1386:Or4c11 UTSW 2 88,695,697 (GRCm39) missense probably benign 0.14
R1618:Or4c11 UTSW 2 88,695,871 (GRCm39) splice site probably null
R1935:Or4c11 UTSW 2 88,695,524 (GRCm39) missense probably benign
R2098:Or4c11 UTSW 2 88,695,215 (GRCm39) missense probably benign 0.43
R2112:Or4c11 UTSW 2 88,695,545 (GRCm39) missense possibly damaging 0.67
R2157:Or4c11 UTSW 2 88,695,213 (GRCm39) missense probably benign
R2912:Or4c11 UTSW 2 88,695,458 (GRCm39) missense probably benign 0.17
R2913:Or4c11 UTSW 2 88,695,458 (GRCm39) missense probably benign 0.17
R4583:Or4c11 UTSW 2 88,695,838 (GRCm39) missense probably benign 0.07
R4631:Or4c11 UTSW 2 88,695,174 (GRCm39) missense probably benign 0.00
R7707:Or4c11 UTSW 2 88,695,153 (GRCm39) missense possibly damaging 0.78
R8559:Or4c11 UTSW 2 88,695,527 (GRCm39) missense probably benign 0.00
R9163:Or4c11 UTSW 2 88,695,795 (GRCm39) missense possibly damaging 0.63
R9164:Or4c11 UTSW 2 88,695,795 (GRCm39) missense possibly damaging 0.63
R9468:Or4c11 UTSW 2 88,695,795 (GRCm39) missense possibly damaging 0.63
Posted On 2014-02-04