Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01783:Or5t7'

154198

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5t7

Ensembl Gene

ENSMUSG00000075175

Gene Name

olfactory receptor family 5 subfamily T member 17

Synonyms

GA_x6K02T2Q125-48168771-48167839, MOR179-2, Olfr1086

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.296) question?

Stock #

IGL01783

Quality Score

Status

Chromosome

Chromosomal Location

86506743-86507683 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 86507425 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 84 (V84A)

Ref Sequence

ENSEMBL: ENSMUSP00000150094 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099878] [ENSMUST00000213198]

AlphaFold

Q8VFL9

Predicted Effect

probably benign
Transcript: ENSMUST00000099878
AA Change: V84A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000097463
Gene: ENSMUSG00000075175
AA Change: V84A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	3.3e-49	PFAM
Pfam:7tm_1	39	288	1.4e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213198
AA Change: V84A

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd13	T	C	8: 10,037,900 (GRCm39)	Y166H	possibly damaging	Het
Abi3bp	G	A	16: 56,353,332 (GRCm39)		probably null	Het
Actrt3	T	C	3: 30,652,624 (GRCm39)	T157A	probably benign	Het
Adam26b	T	C	8: 43,974,798 (GRCm39)	K68R	probably benign	Het
Adgrg7	A	G	16: 56,568,282 (GRCm39)		probably null	Het
Ano6	T	C	15: 95,860,143 (GRCm39)	I755T	possibly damaging	Het
Basp1	T	C	15: 25,364,953 (GRCm39)	N15D	unknown	Het
Bod1l	T	C	5: 41,966,055 (GRCm39)	N2670S	probably benign	Het
Btbd3	T	A	2: 138,125,656 (GRCm39)	I280N	probably damaging	Het
Cdh16	T	A	8: 105,344,488 (GRCm39)	Y17F	probably damaging	Het
Clmp	G	T	9: 40,693,703 (GRCm39)	G307W	possibly damaging	Het
Clrn2	C	A	5: 45,617,503 (GRCm39)	Q125K	probably benign	Het
Ctnna3	C	T	10: 63,656,248 (GRCm39)	A276V	possibly damaging	Het
Dram2	A	T	3: 106,480,972 (GRCm39)	T172S	possibly damaging	Het
Dync2h1	G	A	9: 7,118,822 (GRCm39)		probably benign	Het
Ezr	T	C	17: 7,009,888 (GRCm39)		probably benign	Het
Gbe1	T	A	16: 70,275,257 (GRCm39)	D352E	probably damaging	Het
Gbe1	T	C	16: 70,198,743 (GRCm39)		probably null	Het
Gpr18	T	A	14: 122,149,789 (GRCm39)	M79L	probably benign	Het
Gss	T	C	2: 155,413,479 (GRCm39)	Y196C	probably damaging	Het
Gtpbp1	T	C	15: 79,600,398 (GRCm39)	S444P	probably damaging	Het
Hecw1	C	T	13: 14,452,878 (GRCm39)	R712K	probably damaging	Het
Helz2	T	G	2: 180,874,674 (GRCm39)	D1940A	probably damaging	Het
Hmcn1	A	T	1: 150,491,051 (GRCm39)	V4166E	possibly damaging	Het
Klkb1	T	C	8: 45,729,428 (GRCm39)	Y297C	probably damaging	Het
Krt75	T	A	15: 101,473,364 (GRCm39)	I537F	probably benign	Het
Lrp1b	T	A	2: 41,202,584 (GRCm39)	T1176S	probably damaging	Het
Nid2	T	C	14: 19,818,745 (GRCm39)	L413P	probably benign	Het
Or10ag57	T	A	2: 87,218,187 (GRCm39)	M46K	possibly damaging	Het
Or10ag57	G	T	2: 87,218,182 (GRCm39)	L44F	probably benign	Het
Or4c11	T	C	2: 88,695,186 (GRCm39)	L79P	probably damaging	Het
Piwil1	A	G	5: 128,820,890 (GRCm39)	N272D	probably benign	Het
Ppfia3	T	C	7: 45,009,481 (GRCm39)		probably null	Het
Prkg1	A	G	19: 30,602,089 (GRCm39)	V389A	probably damaging	Het
Sema3a	C	A	5: 13,611,767 (GRCm39)	S344R	probably damaging	Het
Serpina3j	T	C	12: 104,284,750 (GRCm39)	L309P	probably damaging	Het
Slc15a1	A	G	14: 121,708,688 (GRCm39)		probably null	Het
Sp8	G	T	12: 118,812,759 (GRCm39)	A205S	probably benign	Het
Speer4a1	T	A	5: 26,240,045 (GRCm39)	Q235L	possibly damaging	Het
St6gal1	A	G	16: 23,140,305 (GRCm39)	T159A	probably benign	Het
Tbrg1	G	T	9: 37,565,596 (GRCm39)	P119T	possibly damaging	Het
Tmem59l	T	C	8: 70,939,874 (GRCm39)	T32A	probably damaging	Het
Trmt13	G	A	3: 116,376,561 (GRCm39)	R277*	probably null	Het
Zfp316	A	G	5: 143,248,631 (GRCm39)	F205S	unknown	Het
Zfp418	G	T	7: 7,184,448 (GRCm39)	W137L	possibly damaging	Het
Zp3r	A	T	1: 130,526,603 (GRCm39)	V200D	possibly damaging	Het

Other mutations in Or5t7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0492:Or5t7	UTSW	2	86,506,834 (GRCm39)	missense	probably damaging	1.00
R0629:Or5t7	UTSW	2	86,506,873 (GRCm39)	missense	possibly damaging	0.65
R1114:Or5t7	UTSW	2	86,507,629 (GRCm39)	missense	possibly damaging	0.72
R1341:Or5t7	UTSW	2	86,507,507 (GRCm39)	missense	possibly damaging	0.86
R1868:Or5t7	UTSW	2	86,507,629 (GRCm39)	missense	possibly damaging	0.72
R2183:Or5t7	UTSW	2	86,507,380 (GRCm39)	missense	probably benign	0.21
R3159:Or5t7	UTSW	2	86,506,855 (GRCm39)	missense	probably benign	0.03
R4061:Or5t7	UTSW	2	86,507,162 (GRCm39)	missense	probably damaging	1.00
R4420:Or5t7	UTSW	2	86,507,263 (GRCm39)	missense	possibly damaging	0.95
R5514:Or5t7	UTSW	2	86,507,225 (GRCm39)	missense	probably benign	0.03
R7066:Or5t7	UTSW	2	86,507,570 (GRCm39)	missense	possibly damaging	0.95
R7077:Or5t7	UTSW	2	86,507,236 (GRCm39)	missense	possibly damaging	0.78
R7246:Or5t7	UTSW	2	86,507,633 (GRCm39)	missense	probably benign	0.11
R7383:Or5t7	UTSW	2	86,507,263 (GRCm39)	missense	possibly damaging	0.95
R8062:Or5t7	UTSW	2	86,507,410 (GRCm39)	missense	probably benign	0.01
R8271:Or5t7	UTSW	2	86,507,218 (GRCm39)	missense	probably benign	0.12
R8417:Or5t7	UTSW	2	86,507,149 (GRCm39)	missense	probably damaging	1.00
R8927:Or5t7	UTSW	2	86,507,630 (GRCm39)	missense	probably benign	0.31
R8928:Or5t7	UTSW	2	86,507,630 (GRCm39)	missense	probably benign	0.31
R9029:Or5t7	UTSW	2	86,506,831 (GRCm39)	missense	probably damaging	1.00
R9342:Or5t7	UTSW	2	86,507,494 (GRCm39)	missense	probably damaging	1.00
R9384:Or5t7	UTSW	2	86,507,357 (GRCm39)	missense	probably benign	0.21
X0064:Or5t7	UTSW	2	86,507,543 (GRCm39)	missense	probably benign

Posted On

2014-02-04