Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01784:Gm10436'

154234

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm10436

Ensembl Gene

ENSMUSG00000066027

Gene Name

predicted gene 10436

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

IGL01784

Quality Score

Status

Chromosome

Chromosomal Location

88175589-88182108 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 88176315 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 178 (Y178H)

Ref Sequence

ENSEMBL: ENSMUSP00000152292 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071580] [ENSMUST00000220521] [ENSMUST00000222081] [ENSMUST00000223172]

Predicted Effect

probably benign
Transcript: ENSMUST00000071580
AA Change: Y373H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000071508
Gene: ENSMUSG00000066027
AA Change: Y373H

Domain	Start	End	E-Value	Type
SCOP:d1a4ya_	247	445	5e-9	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000220521
AA Change: Y178H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

probably benign
Transcript: ENSMUST00000221884

Predicted Effect

probably benign
Transcript: ENSMUST00000222081

Predicted Effect

probably benign
Transcript: ENSMUST00000222391

Predicted Effect

probably benign
Transcript: ENSMUST00000222556

Predicted Effect

probably benign
Transcript: ENSMUST00000223172

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2810021J22Rik	C	T	11: 58,880,619	P309L	possibly damaging	Het
Abca4	A	T	3: 122,138,505	K269N	probably benign	Het
Abcb5	T	C	12: 118,890,664	T839A	probably benign	Het
Adcy7	A	G	8: 88,314,123	D30G	probably damaging	Het
Aldh3b1	A	G	19: 3,921,217	I149T	probably benign	Het
Ap3b1	A	G	13: 94,493,739	D199G	probably damaging	Het
Ddo	A	G	10: 40,631,788		probably benign	Het
Ensa	T	A	3: 95,628,533		probably benign	Het
Etnppl	A	G	3: 130,631,778	I405V	possibly damaging	Het
Fam129a	T	A	1: 151,649,365	Y174N	probably damaging	Het
Fam171b	T	A	2: 83,879,687	L568M	possibly damaging	Het
Fmn2	A	G	1: 174,502,428	D128G	unknown	Het
Fra10ac1	T	A	19: 38,219,677	H43L	probably benign	Het
Gm7589	T	C	9: 59,146,027		noncoding transcript	Het
Gsx1	A	G	5: 147,190,129	D254G	probably benign	Het
Hoxb6	A	G	11: 96,300,813	E187G	probably damaging	Het
Kmt2c	A	T	5: 25,313,526	I2385N	probably damaging	Het
Lman1l	T	C	9: 57,620,564	Y36C	probably damaging	Het
Mc3r	T	A	2: 172,249,370	C171S	probably benign	Het
Mccc1	T	G	3: 35,976,748	N390H	probably damaging	Het
Mphosph9	T	C	5: 124,265,310		probably benign	Het
Nfic	T	C	10: 81,406,148	D364G	possibly damaging	Het
Npy	A	G	6: 49,829,334		probably benign	Het
Olfr767	C	T	10: 129,079,355	V203M	probably benign	Het
Osbpl3	A	G	6: 50,344,922	S75P	probably damaging	Het
Plekhg4	G	T	8: 105,378,957	A685S	probably damaging	Het
Prss53	T	C	7: 127,886,552	T539A	probably benign	Het
Rnf43	T	A	11: 87,731,806	S537T	possibly damaging	Het
Rpgrip1l	G	A	8: 91,270,461	T597I	possibly damaging	Het
Rtn4	C	A	11: 29,707,291	Q482K	probably damaging	Het
Sema3g	T	C	14: 31,222,967	I349T	probably damaging	Het
Sh3gl1	A	C	17: 56,019,325	S108A	possibly damaging	Het
Tmc7	A	T	7: 118,547,315		probably null	Het
Tmem131	G	A	1: 36,815,483	T131I	probably damaging	Het
Vac14	T	C	8: 110,671,168	L505P	probably benign	Het
Wasf2	A	G	4: 133,192,128	Q231R	unknown	Het
Wnt7a	A	G	6: 91,365,857	C348R	probably damaging	Het
Zkscan6	T	A	11: 65,814,721	L86Q	probably damaging	Het

Other mutations in Gm10436

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00421:Gm10436	APN	12	88177112	missense	probably benign	0.35
IGL01391:Gm10436	APN	12	88178455	missense	possibly damaging	0.84
IGL01432:Gm10436	APN	12	88176432	missense	probably benign	0.44
IGL01519:Gm10436	APN	12	88177561	missense	probably benign	0.00
IGL02121:Gm10436	APN	12	88178472	missense	possibly damaging	0.83
IGL02728:Gm10436	APN	12	88176022	missense	probably benign	0.17
R0336:Gm10436	UTSW	12	88178191	missense	probably benign	0.20
R0554:Gm10436	UTSW	12	88177558	missense	probably benign	0.10
R1279:Gm10436	UTSW	12	88175880	missense	probably benign	0.42
R1832:Gm10436	UTSW	12	88178448	missense	possibly damaging	0.73
R1833:Gm10436	UTSW	12	88178448	missense	possibly damaging	0.73
R1900:Gm10436	UTSW	12	88177260	missense	probably benign	0.02
R2412:Gm10436	UTSW	12	88177110	missense	probably damaging	0.98
R3040:Gm10436	UTSW	12	88178348	missense	probably benign	0.00
R3625:Gm10436	UTSW	12	88175961	missense	probably benign	0.06
R4078:Gm10436	UTSW	12	88175913	missense	probably benign	0.38
R4270:Gm10436	UTSW	12	88178283	missense	probably damaging	1.00
R4271:Gm10436	UTSW	12	88178283	missense	probably damaging	1.00
R5318:Gm10436	UTSW	12	88176228	missense	probably benign	0.01
R5552:Gm10436	UTSW	12	88178365	missense	probably benign	0.03
R5601:Gm10436	UTSW	12	88176047	missense	probably damaging	1.00
R5881:Gm10436	UTSW	12	88176341	missense	probably damaging	1.00
R5973:Gm10436	UTSW	12	88175913	missense	probably benign	0.02
R6058:Gm10436	UTSW	12	88177225	missense	possibly damaging	0.91
R6488:Gm10436	UTSW	12	88177587	missense	possibly damaging	0.87
R6656:Gm10436	UTSW	12	88175993	missense	possibly damaging	0.89
R7307:Gm10436	UTSW	12	88181749	missense	probably damaging	1.00
R7332:Gm10436	UTSW	12	88176417	missense	possibly damaging	0.72
R7544:Gm10436	UTSW	12	88176080	missense	probably benign	0.00
R7569:Gm10436	UTSW	12	88176315	missense	probably benign
R7645:Gm10436	UTSW	12	88176258	missense	probably damaging	1.00
R7752:Gm10436	UTSW	12	88175999	missense	probably damaging	1.00
R7855:Gm10436	UTSW	12	88176083	missense	probably benign	0.03
R7860:Gm10436	UTSW	12	88176352	missense	possibly damaging	0.89
R8113:Gm10436	UTSW	12	88177080	missense	probably benign	0.00
R8356:Gm10436	UTSW	12	88177216	missense	probably benign	0.01
R8456:Gm10436	UTSW	12	88177216	missense	probably benign	0.01

Posted On

2014-02-04