Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01784:Npy'

154260

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Npy

Ensembl Gene

ENSMUSG00000029819

Gene Name

neuropeptide Y

Synonyms

0710005A05Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.178) question?

Stock #

IGL01784

Quality Score

Status

Chromosome

Chromosomal Location

49799690-49806487 bp(+) (GRCm39)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

A to G at 49806314 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000031843 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031843]

AlphaFold

P57774

Predicted Effect

probably benign
Transcript: ENSMUST00000031843

SMART Domains

Protein: ENSMUSP00000031843
Gene: ENSMUSG00000029819

Domain	Start	End	E-Value	Type
signal peptide	1	28	N/A	INTRINSIC
PAH	29	64	5.8e-19	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a neuropeptide that plays a pivotal role in many physiological functions such as food intake, energy homeostasis, circadian rhythm, and cognition. The encoded protein precursor undergoes proteolytic processing to generate the biologically active peptide. Mice lacking the encoded protein exhibit mild seizures occasionally and become hyperphagic following food deprivation. A deficiency of the encoded protein partially prevents mice lacking leptin from becoming obese. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit sporadic mild seizures and increased susceptibility to PTZ-induced seizures. Mice homozygous for a different null allele show hypoactivity and reduced exploratory behavior, an increased anxiety-related response in males, and increased defecation in females. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2810021J22Rik	C	T	11: 58,771,445 (GRCm39)	P309L	possibly damaging	Het
Abca4	A	T	3: 121,932,154 (GRCm39)	K269N	probably benign	Het
Abcb5	T	C	12: 118,854,399 (GRCm39)	T839A	probably benign	Het
Adcy7	A	G	8: 89,040,751 (GRCm39)	D30G	probably damaging	Het
Aldh3b1	A	G	19: 3,971,217 (GRCm39)	I149T	probably benign	Het
Ap3b1	A	G	13: 94,630,247 (GRCm39)	D199G	probably damaging	Het
Cplx3	T	C	9: 57,527,847 (GRCm39)	Y36C	probably damaging	Het
Ddo	A	G	10: 40,507,784 (GRCm39)		probably benign	Het
Ensa	T	A	3: 95,535,844 (GRCm39)		probably benign	Het
Etnppl	A	G	3: 130,425,427 (GRCm39)	I405V	possibly damaging	Het
Fam171b	T	A	2: 83,710,031 (GRCm39)	L568M	possibly damaging	Het
Fmn2	A	G	1: 174,329,994 (GRCm39)	D128G	unknown	Het
Fra10ac1	T	A	19: 38,208,125 (GRCm39)	H43L	probably benign	Het
Gm7589	T	C	9: 59,053,310 (GRCm39)		noncoding transcript	Het
Gsx1	A	G	5: 147,126,939 (GRCm39)	D254G	probably benign	Het
Hoxb6	A	G	11: 96,191,639 (GRCm39)	E187G	probably damaging	Het
Kmt2c	A	T	5: 25,518,524 (GRCm39)	I2385N	probably damaging	Het
Mc3r	T	A	2: 172,091,290 (GRCm39)	C171S	probably benign	Het
Mccc1	T	G	3: 36,030,897 (GRCm39)	N390H	probably damaging	Het
Mphosph9	T	C	5: 124,403,373 (GRCm39)		probably benign	Het
Nfic	T	C	10: 81,241,982 (GRCm39)	D364G	possibly damaging	Het
Niban1	T	A	1: 151,525,116 (GRCm39)	Y174N	probably damaging	Het
Or6c8	C	T	10: 128,915,224 (GRCm39)	V203M	probably benign	Het
Osbpl3	A	G	6: 50,321,902 (GRCm39)	S75P	probably damaging	Het
Plekhg4	G	T	8: 106,105,589 (GRCm39)	A685S	probably damaging	Het
Pramel51	A	G	12: 88,143,085 (GRCm39)	Y178H	probably benign	Het
Prss53	T	C	7: 127,485,724 (GRCm39)	T539A	probably benign	Het
Rnf43	T	A	11: 87,622,632 (GRCm39)	S537T	possibly damaging	Het
Rpgrip1l	G	A	8: 91,997,089 (GRCm39)	T597I	possibly damaging	Het
Rtn4	C	A	11: 29,657,291 (GRCm39)	Q482K	probably damaging	Het
Sema3g	T	C	14: 30,944,924 (GRCm39)	I349T	probably damaging	Het
Sh3gl1	A	C	17: 56,326,325 (GRCm39)	S108A	possibly damaging	Het
Tmc7	A	T	7: 118,146,538 (GRCm39)		probably null	Het
Tmem131	G	A	1: 36,854,564 (GRCm39)	T131I	probably damaging	Het
Vac14	T	C	8: 111,397,800 (GRCm39)	L505P	probably benign	Het
Wasf2	A	G	4: 132,919,439 (GRCm39)	Q231R	unknown	Het
Wnt7a	A	G	6: 91,342,839 (GRCm39)	C348R	probably damaging	Het
Zkscan6	T	A	11: 65,705,547 (GRCm39)	L86Q	probably damaging	Het

Other mutations in Npy

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03038:Npy	APN	6	49,800,588 (GRCm39)	missense	probably benign
R1558:Npy	UTSW	6	49,800,705 (GRCm39)	missense	probably damaging	1.00
R2990:Npy	UTSW	6	49,804,492 (GRCm39)	missense	possibly damaging	0.76
R6519:Npy	UTSW	6	49,800,669 (GRCm39)	missense	possibly damaging	0.88
R7239:Npy	UTSW	6	49,800,587 (GRCm39)	missense	probably benign	0.01
R9435:Npy	UTSW	6	49,804,481 (GRCm39)	missense	probably damaging	1.00
R9489:Npy	UTSW	6	49,804,545 (GRCm39)	missense	possibly damaging	0.88

Posted On

2014-02-04