Incidental Mutation 'IGL01813:Oosp2'
ID154324
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oosp2
Ensembl Gene ENSMUSG00000055895
Gene Nameoocyte secreted protein 2
SynonymsLOC225922, Tmem122, Plac1l
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.073) question?
Stock #IGL01813
Quality Score
Status
Chromosome19
Chromosomal Location11647279-11660559 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 11651483 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 85 (T85A)
Gene Model predicted gene model for transcript(s): [ENSMUST00000121793] [ENSMUST00000135994]
Predicted Effect probably benign
Transcript: ENSMUST00000069681
AA Change: T85A

PolyPhen 2 Score 0.140 (Sensitivity: 0.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000065120
Gene: ENSMUSG00000055895
AA Change: T85A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:Zona_pellucida 30 165 7.1e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000121793
AA Change: T85A

PolyPhen 2 Score 0.082 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000113931
Gene: ENSMUSG00000055895
AA Change: T85A

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000135994
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik G A 3: 36,928,520 S778N possibly damaging Het
Abcb11 T A 2: 69,287,592 probably benign Het
Adgrb2 T C 4: 130,012,566 V929A probably benign Het
Aldh2 T C 5: 121,572,073 I400V probably benign Het
Atxn2l T C 7: 126,500,253 D84G probably damaging Het
Avpr1a T A 10: 122,449,011 N69K probably damaging Het
BC022687 C T 12: 112,815,559 T272M probably damaging Het
BC034090 G A 1: 155,226,339 Q60* probably null Het
Bub3 T C 7: 131,568,633 S295P probably benign Het
Cacna1b T C 2: 24,609,890 S161G probably damaging Het
Col6a4 T A 9: 106,077,253 S296C probably damaging Het
Cyp4f15 G A 17: 32,686,157 R38H probably benign Het
Dync2h1 T C 9: 7,122,799 I2052M probably damaging Het
Gm11627 T C 11: 102,578,808 probably benign Het
Jmjd8 A T 17: 25,829,238 probably null Het
Kmt2c A G 5: 25,290,804 V629A possibly damaging Het
Kremen1 T C 11: 5,199,667 T335A probably benign Het
Olfr109 A G 17: 37,466,758 E184G probably damaging Het
Olfr282 A G 15: 98,437,649 Y60C possibly damaging Het
Pex5l T C 3: 33,082,055 E5G probably benign Het
Pigk A T 3: 152,742,519 Q173L probably damaging Het
Pik3c2g T A 6: 139,622,409 N174K possibly damaging Het
Plb1 C T 5: 32,329,085 H893Y probably damaging Het
Pus7 T C 5: 23,760,304 probably benign Het
R3hdm1 G A 1: 128,175,233 probably null Het
Samd7 C T 3: 30,754,286 P83S probably benign Het
Supt5 T A 7: 28,323,975 Y293F probably damaging Het
Tbc1d30 T C 10: 121,267,051 D692G probably benign Het
Tmpo G A 10: 91,163,242 R228C probably benign Het
Tnn A T 1: 160,088,438 H1236Q probably damaging Het
Ubr3 T C 2: 69,951,570 I667T probably benign Het
Vmn1r183 T A 7: 24,055,560 F263I probably benign Het
Other mutations in Oosp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01323:Oosp2 APN 19 11647461 missense probably damaging 1.00
IGL01818:Oosp2 APN 19 11649689 missense probably benign 0.02
IGL02484:Oosp2 APN 19 11651483 missense probably benign 0.14
IGL03358:Oosp2 APN 19 11651569 nonsense probably null
R0938:Oosp2 UTSW 19 11651540 nonsense probably null
R1867:Oosp2 UTSW 19 11649595 critical splice donor site probably null
R1944:Oosp2 UTSW 19 11649595 critical splice donor site probably null
R1945:Oosp2 UTSW 19 11649595 critical splice donor site probably null
R2149:Oosp2 UTSW 19 11649614 nonsense probably null
R4604:Oosp2 UTSW 19 11649683 missense probably benign 0.01
R4684:Oosp2 UTSW 19 11649653 missense probably damaging 0.98
R5034:Oosp2 UTSW 19 11651535 missense probably damaging 0.99
R6034:Oosp2 UTSW 19 11651515 missense probably damaging 1.00
R6034:Oosp2 UTSW 19 11651515 missense probably damaging 1.00
Posted On2014-02-04