Incidental Mutation 'IGL01815:Olfr1457'
ID154387
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1457
Ensembl Gene ENSMUSG00000061637
Gene Nameolfactory receptor 1457
SynonymsGA_x6K02T2RE5P-3423041-3422097, MOR202-20
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.070) question?
Stock #IGL01815
Quality Score
Status
Chromosome19
Chromosomal Location13093379-13097891 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 13095656 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150957 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075170] [ENSMUST00000208913] [ENSMUST00000214561] [ENSMUST00000215229]
Predicted Effect probably null
Transcript: ENSMUST00000075170
SMART Domains Protein: ENSMUSP00000074665
Gene: ENSMUSG00000061637

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 3.6e-45 PFAM
Pfam:7tm_1 42 291 9.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208913
Predicted Effect probably benign
Transcript: ENSMUST00000214561
Predicted Effect probably null
Transcript: ENSMUST00000215229
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap3 A G 4: 155,902,187 E324G probably damaging Het
Arhgap20 T A 9: 51,846,168 Y487N probably damaging Het
Babam2 C T 5: 31,702,098 A3V possibly damaging Het
Fat4 T C 3: 38,888,773 L605P probably damaging Het
Frmpd1 A G 4: 45,284,239 H1020R probably benign Het
Ighv1-53 T A 12: 115,158,597 M53L probably benign Het
Lepr A T 4: 101,814,790 I1004F possibly damaging Het
Limd1 T C 9: 123,479,736 S167P probably benign Het
Lrrc10b T C 19: 10,456,753 D188G probably damaging Het
Nlrp4e T C 7: 23,321,438 L450P probably benign Het
Olfr58 A G 9: 19,784,015 N294S probably damaging Het
Olfr657 T A 7: 104,636,345 Y224N probably damaging Het
Olfr836 G T 9: 19,121,326 D121Y probably damaging Het
P2ry13 T C 3: 59,209,700 N219S probably benign Het
Pcnx A G 12: 81,990,551 D1861G probably damaging Het
Phlpp2 A G 8: 109,939,859 I1007V probably benign Het
Ppp2r1a A G 17: 20,956,832 N211D probably benign Het
Psmd5 A T 2: 34,852,771 F440L probably benign Het
Rpe65 T A 3: 159,604,530 probably null Het
Utrn T C 10: 12,652,716 T2172A probably benign Het
Vwa8 C T 14: 79,198,277 T1809M possibly damaging Het
Wdr70 C T 15: 7,887,324 probably null Het
Other mutations in Olfr1457
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01143:Olfr1457 APN 19 13095112 missense probably damaging 1.00
IGL02033:Olfr1457 APN 19 13094857 missense possibly damaging 0.54
R0490:Olfr1457 UTSW 19 13094812 missense probably damaging 1.00
R1205:Olfr1457 UTSW 19 13095535 missense probably benign 0.01
R1299:Olfr1457 UTSW 19 13095130 missense possibly damaging 0.78
R1782:Olfr1457 UTSW 19 13094803 missense probably damaging 0.99
R1983:Olfr1457 UTSW 19 13095384 missense probably benign 0.01
R2364:Olfr1457 UTSW 19 13094754 missense probably damaging 1.00
R3815:Olfr1457 UTSW 19 13094913 missense probably damaging 0.98
R4092:Olfr1457 UTSW 19 13095426 missense probably damaging 0.97
R4430:Olfr1457 UTSW 19 13095088 missense probably benign 0.03
R7200:Olfr1457 UTSW 19 13095232 missense probably benign 0.04
R8079:Olfr1457 UTSW 19 13095284 nonsense probably null
Posted On2014-02-04