Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01819:Vmn2r45'

154454

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r45

Ensembl Gene

ENSMUSG00000090662

Gene Name

vomeronasal 2, receptor 45

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.136) question?

Stock #

IGL01819

Quality Score

Status

Chromosome

Chromosomal Location

8470525-8489075 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 8485557 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Isoleucine at position 158 (S158I)

Ref Sequence

ENSEMBL: ENSMUSP00000129466 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164845]

AlphaFold

L7N2B5

Predicted Effect

probably benign
Transcript: ENSMUST00000164845
AA Change: S158I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: S158I

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	154	469	4.5e-26	PFAM
Pfam:NCD3G	512	565	6.4e-21	PFAM
Pfam:7tm_3	598	833	2.1e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610010F05Rik	A	G	11: 23,584,561	S105P	probably benign	Het
Adora2b	A	G	11: 62,265,184	N153S	possibly damaging	Het
Afm	C	T	5: 90,524,906	T200I	probably benign	Het
Cyp2c67	T	C	19: 39,615,721	D397G	probably damaging	Het
Dnah9	A	G	11: 66,108,126	V1032A	probably benign	Het
Elovl7	T	G	13: 108,274,320	V143G	probably damaging	Het
Fhl4	T	C	10: 85,098,870	K16E	probably damaging	Het
Golga1	C	T	2: 39,034,149	C383Y	probably benign	Het
Gucy1a2	C	T	9: 3,865,409	R628*	probably null	Het
Hectd4	A	G	5: 121,328,418	D2432G	possibly damaging	Het
Iqcf5	T	A	9: 106,515,990	*149R	probably null	Het
Kcnab1	T	A	3: 65,319,454	Y185N	probably damaging	Het
Lars	G	T	18: 42,202,550	T1167K	probably benign	Het
Mib2	A	T	4: 155,655,258		probably null	Het
Mrps2	T	C	2: 28,468,336	V46A	probably benign	Het
Myo18b	T	C	5: 112,878,050	T45A	unknown	Het
Myo1e	C	T	9: 70,343,040		probably benign	Het
Olfr1129	A	G	2: 87,575,479	I132V	probably damaging	Het
Olfr1285	T	A	2: 111,408,733	V106E	probably damaging	Het
Osbp2	A	T	11: 3,717,127	I8N	probably damaging	Het
Pcdhb22	A	T	18: 37,519,921	N481Y	probably damaging	Het
Pde3a	T	C	6: 141,487,537	W765R	probably damaging	Het
Phf11c	T	C	14: 59,393,137	T40A	probably benign	Het
Pih1d2	T	A	9: 50,621,877	S268R	probably benign	Het
Pkd1l2	T	C	8: 116,998,174	N2333D	probably damaging	Het
Prex1	A	G	2: 166,621,245	I62T	probably damaging	Het
Ptcd2	T	C	13: 99,326,711	N245S	possibly damaging	Het
Ripor3	C	A	2: 167,980,843	V933F	probably damaging	Het
Sphk2	A	G	7: 45,711,056		probably null	Het
Tfcp2	T	G	15: 100,504,439	E492D	probably benign	Het
Ttn	C	T	2: 76,798,762	V14411I	possibly damaging	Het
Utp20	T	C	10: 88,792,687	Q915R	probably damaging	Het

Other mutations in Vmn2r45

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01287:Vmn2r45	APN	7	8485623	missense	probably benign	0.00
IGL01322:Vmn2r45	APN	7	8481333	missense	possibly damaging	0.49
IGL01402:Vmn2r45	APN	7	8481468	missense	probably damaging	0.98
IGL01404:Vmn2r45	APN	7	8481468	missense	probably damaging	0.98
IGL01529:Vmn2r45	APN	7	8483494	missense	probably benign
IGL01596:Vmn2r45	APN	7	8483273	missense	probably damaging	0.98
IGL01646:Vmn2r45	APN	7	8483338	missense	probably benign	0.18
IGL02096:Vmn2r45	APN	7	8481444	missense	probably damaging	0.99
IGL02130:Vmn2r45	APN	7	8483557	missense	possibly damaging	0.46
IGL02409:Vmn2r45	APN	7	8485728	missense	probably benign	0.03
IGL02517:Vmn2r45	APN	7	8483186	nonsense	probably null
IGL02633:Vmn2r45	APN	7	8485729	missense	probably benign	0.01
IGL02940:Vmn2r45	APN	7	8472370	missense	probably damaging	0.99
IGL03281:Vmn2r45	APN	7	8483604	missense	probably damaging	1.00
IGL03358:Vmn2r45	APN	7	8471716	missense	probably damaging	1.00
BB004:Vmn2r45	UTSW	7	8483514	missense	probably benign
BB014:Vmn2r45	UTSW	7	8483514	missense	probably benign
R0382:Vmn2r45	UTSW	7	8483099	missense	probably benign	0.06
R0532:Vmn2r45	UTSW	7	8471821	missense	probably damaging	0.99
R0932:Vmn2r45	UTSW	7	8475381	missense	probably damaging	1.00
R1125:Vmn2r45	UTSW	7	8485543	missense	probably benign	0.00
R1580:Vmn2r45	UTSW	7	8471747	missense	possibly damaging	0.95
R1817:Vmn2r45	UTSW	7	8472373	missense	probably damaging	1.00
R1996:Vmn2r45	UTSW	7	8472025	missense	probably damaging	1.00
R2050:Vmn2r45	UTSW	7	8472022	missense	probably damaging	1.00
R2284:Vmn2r45	UTSW	7	8485766	missense	probably benign	0.02
R4019:Vmn2r45	UTSW	7	8471581	nonsense	probably null
R4227:Vmn2r45	UTSW	7	8483278	missense	probably damaging	0.98
R4381:Vmn2r45	UTSW	7	8471913	nonsense	probably null
R4618:Vmn2r45	UTSW	7	8483437	missense	probably benign	0.00
R4624:Vmn2r45	UTSW	7	8481342	missense	probably damaging	1.00
R4704:Vmn2r45	UTSW	7	8483536	nonsense	probably null
R4735:Vmn2r45	UTSW	7	8483473	missense	probably damaging	1.00
R4868:Vmn2r45	UTSW	7	8481481	missense	probably benign	0.06
R4983:Vmn2r45	UTSW	7	8483117	missense	probably damaging	0.99
R5246:Vmn2r45	UTSW	7	8483252	missense	probably benign	0.00
R5430:Vmn2r45	UTSW	7	8483334	nonsense	probably null
R5504:Vmn2r45	UTSW	7	8483177	missense	probably benign	0.03
R5511:Vmn2r45	UTSW	7	8471833	missense	probably benign	0.19
R5745:Vmn2r45	UTSW	7	8483075	missense	probably benign	0.00
R5814:Vmn2r45	UTSW	7	8471476	missense	probably benign	0.00
R6223:Vmn2r45	UTSW	7	8483302	missense	probably benign
R6267:Vmn2r45	UTSW	7	8472208	missense	probably benign	0.26
R6623:Vmn2r45	UTSW	7	8471501	missense	probably benign	0.09
R6999:Vmn2r45	UTSW	7	8483220	missense	probably benign
R7242:Vmn2r45	UTSW	7	8485613	nonsense	probably null
R7491:Vmn2r45	UTSW	7	8481343	missense	probably benign	0.27
R7620:Vmn2r45	UTSW	7	8483223	nonsense	probably null
R7719:Vmn2r45	UTSW	7	8483461	missense	probably damaging	0.99
R7720:Vmn2r45	UTSW	7	8483461	missense	probably damaging	0.99
R7853:Vmn2r45	UTSW	7	8482988	missense	possibly damaging	0.90
R7873:Vmn2r45	UTSW	7	8483075	missense	probably benign	0.00
R7882:Vmn2r45	UTSW	7	8483410	missense	possibly damaging	0.82
R7927:Vmn2r45	UTSW	7	8483514	missense	probably benign
R8684:Vmn2r45	UTSW	7	8483512	missense	probably damaging	0.99
R8780:Vmn2r45	UTSW	7	8481372	missense	possibly damaging	0.94
R8811:Vmn2r45	UTSW	7	8471882	missense	probably damaging	1.00
R8893:Vmn2r45	UTSW	7	8485620	missense	probably damaging	1.00
R9043:Vmn2r45	UTSW	7	8471905	missense	possibly damaging	0.92
R9208:Vmn2r45	UTSW	7	8483299	missense	probably damaging	1.00
R9327:Vmn2r45	UTSW	7	8471533	missense	probably damaging	1.00
R9586:Vmn2r45	UTSW	7	8483051	missense	probably benign	0.01
R9599:Vmn2r45	UTSW	7	8475458	critical splice acceptor site	probably null
U24488:Vmn2r45	UTSW	7	8472362	missense	probably damaging	1.00
Z1088:Vmn2r45	UTSW	7	8471485	missense	probably benign	0.16

Posted On

2014-02-04