Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01820:Prl5a1'

154487

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prl5a1

Ensembl Gene

ENSMUSG00000017064

Gene Name

prolactin family 5, subfamily a, member 1

Synonyms

D13Wsu14e, 1600013P04Rik, Prlpl, PLP-L

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL01820

Quality Score

Status

Chromosome

Chromosomal Location

28142484-28151611 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 28148700 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 94 (S94P)

Ref Sequence

ENSEMBL: ENSMUSP00000017208 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000017208]

AlphaFold

Q9JII2

Predicted Effect

probably benign
Transcript: ENSMUST00000017208
AA Change: S94P

PolyPhen 2 Score 0.339 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000017208
Gene: ENSMUSG00000017064
AA Change: S94P

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	17	230	4.8e-50	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1a	A	G	5: 8,715,896		probably benign	Het
Adcy2	T	C	13: 68,738,545		probably null	Het
Akna	G	T	4: 63,386,258	T553N	probably benign	Het
Boc	A	G	16: 44,491,872	I609T	possibly damaging	Het
Btbd9	C	T	17: 30,527,409	V148I	possibly damaging	Het
Cacna1d	A	T	14: 30,042,866	I2049N	possibly damaging	Het
Cdhr1	A	T	14: 37,085,579	M368K	probably benign	Het
Cftr	A	G	6: 18,226,139	Y362C	probably damaging	Het
Cnppd1	G	T	1: 75,139,592		probably null	Het
Col3a1	T	C	1: 45,321,608	I66T	unknown	Het
Col5a2	C	A	1: 45,442,825	M46I	unknown	Het
Csmd3	G	T	15: 47,607,142	C3379*	probably null	Het
Ctla2b	T	A	13: 60,896,689	*28C	probably null	Het
Ddhd2	C	T	8: 25,749,754	E33K	possibly damaging	Het
Dock3	T	C	9: 106,895,893	H387R	probably damaging	Het
Dyrk1b	T	A	7: 28,181,600		probably benign	Het
Fam131c	T	C	4: 141,380,337	C53R	probably damaging	Het
Fat1	T	A	8: 45,010,502	F1360L	probably damaging	Het
Gm10320	G	T	13: 98,489,537	S113*	probably null	Het
Ifih1	T	C	2: 62,617,313	D349G	probably damaging	Het
Il12a	T	C	3: 68,692,162		probably benign	Het
Ivl	A	T	3: 92,571,633	M375K	possibly damaging	Het
Krt82	C	A	15: 101,543,452		probably benign	Het
Mc4r	C	T	18: 66,859,155	V296I	probably benign	Het
Met	T	A	6: 17,534,231	I691N	possibly damaging	Het
Mycbp2	A	T	14: 103,188,501	I2396K	probably damaging	Het
Napg	C	A	18: 62,986,445	Q135K	probably benign	Het
Nf2	A	T	11: 4,789,655		probably null	Het
Nrxn1	G	T	17: 90,643,103	H549Q	probably damaging	Het
P4ha1	T	A	10: 59,361,914	I321K	probably damaging	Het
Prnp	T	C	2: 131,937,070	V214A	probably benign	Het
Ptprc	A	T	1: 138,066,198	F1165I	probably damaging	Het
Rdh10	T	C	1: 16,128,259	V207A	possibly damaging	Het
Rel	A	T	11: 23,753,218	N131K	probably benign	Het
Rgs14	A	T	13: 55,383,525	D448V	probably benign	Het
Spag5	T	G	11: 78,304,259	S131A	probably benign	Het
Styxl1	C	T	5: 135,765,750	D88N	probably damaging	Het
Tlr3	C	T	8: 45,398,339	R507H	probably benign	Het
Ttn	C	T	2: 76,786,326	E16528K	possibly damaging	Het
Txlnb	T	C	10: 17,806,858		probably null	Het
Unc13a	A	G	8: 71,654,947	V567A	probably damaging	Het
Vmn1r8	T	C	6: 57,036,668	S235P	possibly damaging	Het
Vmn2r51	T	A	7: 10,105,482	N60Y	probably damaging	Het
Wbp1l	T	A	19: 46,652,483	L68Q	probably damaging	Het
Wdfy3	A	T	5: 101,924,081	V981E	probably benign	Het
Zdhhc13	T	C	7: 48,808,865	S316P	probably damaging	Het
Zfp516	C	T	18: 82,987,361	R797C	probably benign	Het
Zp3r	A	G	1: 130,598,920	V182A	probably benign	Het

Other mutations in Prl5a1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01638:Prl5a1	APN	13	28145439	missense	possibly damaging	0.77
IGL02682:Prl5a1	APN	13	28145420	missense	probably benign	0.32
R0266:Prl5a1	UTSW	13	28149987	missense	possibly damaging	0.77
R1022:Prl5a1	UTSW	13	28149897	missense	probably damaging	0.97
R1024:Prl5a1	UTSW	13	28149897	missense	probably damaging	0.97
R2098:Prl5a1	UTSW	13	28145505	missense	probably damaging	1.00
R5467:Prl5a1	UTSW	13	28150011	missense	possibly damaging	0.92
R6002:Prl5a1	UTSW	13	28145482	missense	probably benign	0.00
R6026:Prl5a1	UTSW	13	28151264	missense	probably benign	0.43
R6242:Prl5a1	UTSW	13	28142555	nonsense	probably null
R6616:Prl5a1	UTSW	13	28149856	missense	probably benign	0.00
R6733:Prl5a1	UTSW	13	28149936	missense	possibly damaging	0.81
R6979:Prl5a1	UTSW	13	28151206	missense	probably benign	0.32
R7692:Prl5a1	UTSW	13	28150014	missense	probably damaging	1.00
R9610:Prl5a1	UTSW	13	28145509	missense	possibly damaging	0.71
R9611:Prl5a1	UTSW	13	28145509	missense	possibly damaging	0.71

Posted On

2014-02-04