Incidental Mutation 'IGL01820:Zp3r'
ID 154525
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zp3r
Ensembl Gene ENSMUSG00000042554
Gene Name zona pellucida 3 receptor
Synonyms SP56
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # IGL01820
Quality Score
Status
Chromosome 1
Chromosomal Location 130504450-130557358 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 130526657 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 182 (V182A)
Ref Sequence ENSEMBL: ENSMUSP00000045443 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039862] [ENSMUST00000128128] [ENSMUST00000142416]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000039862
AA Change: V182A

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000045443
Gene: ENSMUSG00000042554
AA Change: V182A

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
CCP 34 91 2.52e-7 SMART
CCP 96 153 3.17e-13 SMART
CCP 158 218 8.23e-12 SMART
CCP 223 278 1.77e-11 SMART
CCP 283 345 5.32e-6 SMART
CCP 350 411 3.67e-9 SMART
CCP 456 509 6.95e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082461
Predicted Effect probably benign
Transcript: ENSMUST00000128128
SMART Domains Protein: ENSMUSP00000114401
Gene: ENSMUSG00000042554

DomainStartEndE-ValueType
CCP 55 112 2.52e-7 SMART
CCP 117 174 3.17e-13 SMART
CCP 179 234 1.77e-11 SMART
CCP 239 301 5.32e-6 SMART
CCP 306 367 3.67e-9 SMART
CCP 412 465 6.95e-10 SMART
PDB:4B0F|G 468 513 8e-8 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000142416
SMART Domains Protein: ENSMUSP00000118784
Gene: ENSMUSG00000042554

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
CCP 34 91 2.52e-7 SMART
CCP 96 153 3.17e-13 SMART
CCP 158 213 1.77e-11 SMART
CCP 218 280 5.32e-6 SMART
CCP 285 346 3.67e-9 SMART
CCP 391 444 6.95e-10 SMART
PDB:4B0F|G 447 492 8e-8 PDB
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal fertility and sperm morphology and physiology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a A G 5: 8,765,896 (GRCm39) probably benign Het
Adcy2 T C 13: 68,886,664 (GRCm39) probably null Het
Akna G T 4: 63,304,495 (GRCm39) T553N probably benign Het
Boc A G 16: 44,312,235 (GRCm39) I609T possibly damaging Het
Btbd9 C T 17: 30,746,383 (GRCm39) V148I possibly damaging Het
Cacna1d A T 14: 29,764,823 (GRCm39) I2049N possibly damaging Het
Cdhr1 A T 14: 36,807,536 (GRCm39) M368K probably benign Het
Cftr A G 6: 18,226,138 (GRCm39) Y362C probably damaging Het
Cnppd1 G T 1: 75,116,236 (GRCm39) probably null Het
Col3a1 T C 1: 45,360,768 (GRCm39) I66T unknown Het
Col5a2 C A 1: 45,481,985 (GRCm39) M46I unknown Het
Csmd3 G T 15: 47,470,538 (GRCm39) C3379* probably null Het
Ctla2b T A 13: 61,044,503 (GRCm39) *28C probably null Het
Ddhd2 C T 8: 26,239,781 (GRCm39) E33K possibly damaging Het
Dock3 T C 9: 106,773,092 (GRCm39) H387R probably damaging Het
Dyrk1b T A 7: 27,881,025 (GRCm39) probably benign Het
Fam131c T C 4: 141,107,648 (GRCm39) C53R probably damaging Het
Fat1 T A 8: 45,463,539 (GRCm39) F1360L probably damaging Het
Gm10320 G T 13: 98,626,045 (GRCm39) S113* probably null Het
Ifih1 T C 2: 62,447,657 (GRCm39) D349G probably damaging Het
Il12a T C 3: 68,599,495 (GRCm39) probably benign Het
Ivl A T 3: 92,478,940 (GRCm39) M375K possibly damaging Het
Krt82 C A 15: 101,451,887 (GRCm39) probably benign Het
Mc4r C T 18: 66,992,226 (GRCm39) V296I probably benign Het
Met T A 6: 17,534,230 (GRCm39) I691N possibly damaging Het
Mycbp2 A T 14: 103,425,937 (GRCm39) I2396K probably damaging Het
Napg C A 18: 63,119,516 (GRCm39) Q135K probably benign Het
Nf2 A T 11: 4,739,655 (GRCm39) probably null Het
Nrxn1 G T 17: 90,950,531 (GRCm39) H549Q probably damaging Het
P4ha1 T A 10: 59,197,736 (GRCm39) I321K probably damaging Het
Prl5a1 T C 13: 28,332,683 (GRCm39) S94P probably benign Het
Prnp T C 2: 131,778,990 (GRCm39) V214A probably benign Het
Ptprc A T 1: 137,993,936 (GRCm39) F1165I probably damaging Het
Rdh10 T C 1: 16,198,483 (GRCm39) V207A possibly damaging Het
Rel A T 11: 23,703,218 (GRCm39) N131K probably benign Het
Rgs14 A T 13: 55,531,338 (GRCm39) D448V probably benign Het
Spag5 T G 11: 78,195,085 (GRCm39) S131A probably benign Het
Styxl1 C T 5: 135,794,604 (GRCm39) D88N probably damaging Het
Tlr3 C T 8: 45,851,376 (GRCm39) R507H probably benign Het
Ttn C T 2: 76,616,670 (GRCm39) E16528K possibly damaging Het
Txlnb T C 10: 17,682,606 (GRCm39) probably null Het
Unc13a A G 8: 72,107,591 (GRCm39) V567A probably damaging Het
Vmn1r8 T C 6: 57,013,653 (GRCm39) S235P possibly damaging Het
Vmn2r51 T A 7: 9,839,409 (GRCm39) N60Y probably damaging Het
Wbp1l T A 19: 46,640,922 (GRCm39) L68Q probably damaging Het
Wdfy3 A T 5: 102,071,947 (GRCm39) V981E probably benign Het
Zdhhc13 T C 7: 48,458,613 (GRCm39) S316P probably damaging Het
Zfp516 C T 18: 83,005,486 (GRCm39) R797C probably benign Het
Other mutations in Zp3r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01352:Zp3r APN 1 130,547,093 (GRCm39) missense possibly damaging 0.88
IGL01783:Zp3r APN 1 130,526,603 (GRCm39) missense possibly damaging 0.72
IGL01959:Zp3r APN 1 130,519,188 (GRCm39) nonsense probably null
IGL01978:Zp3r APN 1 130,526,678 (GRCm39) missense probably damaging 1.00
IGL02232:Zp3r APN 1 130,524,404 (GRCm39) missense probably damaging 1.00
IGL02290:Zp3r APN 1 130,547,102 (GRCm39) missense possibly damaging 0.89
IGL02878:Zp3r APN 1 130,510,588 (GRCm39) missense probably benign 0.02
IGL02960:Zp3r APN 1 130,511,175 (GRCm39) missense possibly damaging 0.67
BB006:Zp3r UTSW 1 130,519,217 (GRCm39) missense probably benign 0.31
BB016:Zp3r UTSW 1 130,519,217 (GRCm39) missense probably benign 0.31
PIT4403001:Zp3r UTSW 1 130,510,609 (GRCm39) missense possibly damaging 0.93
R0433:Zp3r UTSW 1 130,504,870 (GRCm39) splice site probably benign
R0491:Zp3r UTSW 1 130,546,071 (GRCm39) missense probably damaging 1.00
R0781:Zp3r UTSW 1 130,505,621 (GRCm39) critical splice donor site probably null
R1110:Zp3r UTSW 1 130,505,621 (GRCm39) critical splice donor site probably null
R1126:Zp3r UTSW 1 130,546,079 (GRCm39) missense probably damaging 1.00
R1295:Zp3r UTSW 1 130,519,181 (GRCm39) missense probably damaging 1.00
R1680:Zp3r UTSW 1 130,510,617 (GRCm39) missense probably benign 0.15
R1728:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1728:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1729:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1729:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1730:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1730:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1739:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1739:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1762:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1762:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1783:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1783:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1784:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1784:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1785:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1785:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R3942:Zp3r UTSW 1 130,504,791 (GRCm39) missense possibly damaging 0.94
R4429:Zp3r UTSW 1 130,519,128 (GRCm39) missense possibly damaging 0.95
R4571:Zp3r UTSW 1 130,505,757 (GRCm39) missense probably damaging 1.00
R4626:Zp3r UTSW 1 130,542,912 (GRCm39) missense probably damaging 1.00
R4647:Zp3r UTSW 1 130,505,697 (GRCm39) missense probably damaging 1.00
R4790:Zp3r UTSW 1 130,510,629 (GRCm39) missense probably damaging 1.00
R4815:Zp3r UTSW 1 130,526,649 (GRCm39) missense probably damaging 1.00
R5355:Zp3r UTSW 1 130,524,518 (GRCm39) missense probably benign 0.09
R5554:Zp3r UTSW 1 130,511,208 (GRCm39) missense probably benign 0.42
R5629:Zp3r UTSW 1 130,510,616 (GRCm39) missense probably damaging 0.99
R6154:Zp3r UTSW 1 130,526,642 (GRCm39) missense probably damaging 1.00
R6173:Zp3r UTSW 1 130,519,305 (GRCm39) splice site probably null
R6949:Zp3r UTSW 1 130,505,632 (GRCm39) missense probably benign 0.00
R7346:Zp3r UTSW 1 130,511,217 (GRCm39) missense probably benign 0.02
R7399:Zp3r UTSW 1 130,504,790 (GRCm39) missense probably damaging 0.98
R7929:Zp3r UTSW 1 130,519,217 (GRCm39) missense probably benign 0.31
R7944:Zp3r UTSW 1 130,524,560 (GRCm39) missense probably damaging 1.00
R7945:Zp3r UTSW 1 130,524,560 (GRCm39) missense probably damaging 1.00
R8367:Zp3r UTSW 1 130,526,610 (GRCm39) missense probably damaging 1.00
R8742:Zp3r UTSW 1 130,511,230 (GRCm39) missense probably damaging 1.00
Posted On 2014-02-04