Incidental Mutation 'IGL01822:Fabp12'
ID154567
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fabp12
Ensembl Gene ENSMUSG00000027530
Gene Namefatty acid binding protein 12
Synonyms1700008G05Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #IGL01822
Quality Score
Status
Chromosome3
Chromosomal Location10244209-10301183 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 10246022 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 127 (R127*)
Ref Sequence ENSEMBL: ENSMUSP00000131101 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029043] [ENSMUST00000117917] [ENSMUST00000119761] [ENSMUST00000172126]
Predicted Effect probably null
Transcript: ENSMUST00000029043
AA Change: R127*
SMART Domains Protein: ENSMUSP00000029043
Gene: ENSMUSG00000027530
AA Change: R127*

DomainStartEndE-ValueType
Pfam:Lipocalin 6 132 1.4e-25 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000117917
AA Change: R127*
SMART Domains Protein: ENSMUSP00000112464
Gene: ENSMUSG00000027530
AA Change: R127*

DomainStartEndE-ValueType
Pfam:Lipocalin 6 132 1.4e-25 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000119761
AA Change: R127*
SMART Domains Protein: ENSMUSP00000112958
Gene: ENSMUSG00000027530
AA Change: R127*

DomainStartEndE-ValueType
Pfam:Lipocalin 6 132 1.4e-25 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000172126
AA Change: R127*
SMART Domains Protein: ENSMUSP00000131101
Gene: ENSMUSG00000027530
AA Change: R127*

DomainStartEndE-ValueType
Pfam:Lipocalin 6 132 1.4e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194040
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cald1 A T 6: 34,753,572 T269S probably damaging Het
Cntnap5c T A 17: 58,055,705 I351N probably damaging Het
Dhcr7 T A 7: 143,845,499 I296N probably damaging Het
Dnah17 A G 11: 118,081,993 F2038S probably damaging Het
Dsel A G 1: 111,861,896 L303P probably damaging Het
Fgf12 A T 16: 28,189,599 S150T possibly damaging Het
Fkbp15 A G 4: 62,352,504 M32T probably benign Het
Lrrc66 G A 5: 73,629,968 T13I probably benign Het
Mmgt2 T C 11: 62,665,006 V60A possibly damaging Het
Neb G T 2: 52,258,746 S2596R possibly damaging Het
Nfkbib T C 7: 28,761,709 D171G probably benign Het
Oas1a T C 5: 120,899,214 E250G probably benign Het
Olfr1197 A T 2: 88,728,792 I269N probably benign Het
Olfr134 C A 17: 38,175,448 D121E probably damaging Het
Rnf182 T C 13: 43,668,032 C20R probably damaging Het
Scn3a T C 2: 65,495,264 K970E probably damaging Het
Slc30a2 T A 4: 134,348,637 Y192N probably damaging Het
Ttn C T 2: 76,786,326 E16528K possibly damaging Het
Vmn2r100 T A 17: 19,504,838 C10S probably null Het
Vmn2r61 A T 7: 42,300,706 H850L probably benign Het
Vmn2r87 T C 10: 130,472,122 Y749C probably damaging Het
Wnt5b A T 6: 119,433,472 C336S probably damaging Het
Zfp398 G A 6: 47,866,271 R287Q probably damaging Het
Other mutations in Fabp12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00551:Fabp12 APN 3 10246055 splice site probably benign
IGL00957:Fabp12 APN 3 10250213 critical splice acceptor site probably null
IGL01774:Fabp12 APN 3 10247694 missense probably benign 0.00
IGL02047:Fabp12 APN 3 10247718 splice site probably benign
IGL02164:Fabp12 APN 3 10246015 missense probably damaging 0.99
IGL03108:Fabp12 APN 3 10250054 missense probably benign 0.12
R0501:Fabp12 UTSW 3 10250143 missense probably benign 0.00
R0647:Fabp12 UTSW 3 10246036 missense possibly damaging 0.55
R1134:Fabp12 UTSW 3 10247671 missense probably benign 0.17
R2020:Fabp12 UTSW 3 10250149 missense probably benign 0.00
R5269:Fabp12 UTSW 3 10250107 missense probably benign 0.12
R7434:Fabp12 UTSW 3 10247678 missense probably benign 0.10
Posted On2014-02-04