Incidental Mutation 'IGL01824:Ifna15'
ID154614
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifna15
Ensembl Gene ENSMUSG00000096011
Gene Nameinterferon alpha 15
SynonymsIfnaa, Gm12597
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.081) question?
Stock #IGL01824
Quality Score
Status
Chromosome4
Chromosomal Location88557673-88558245 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 88557783 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Glycine at position 155 (R155G)
Ref Sequence ENSEMBL: ENSMUSP00000099873 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102809]
Predicted Effect probably benign
Transcript: ENSMUST00000102809
AA Change: R155G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000099873
Gene: ENSMUSG00000096011
AA Change: R155G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 2.97e-68 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd17c G A 7: 84,151,289 R186C probably benign Het
Ankar A G 1: 72,651,727 V1196A probably benign Het
Asah1 A T 8: 41,349,543 probably benign Het
Chrm1 T C 19: 8,679,130 W400R probably damaging Het
Cyp27a1 G T 1: 74,735,881 E290* probably null Het
Dnah7a T C 1: 53,504,270 D2247G probably benign Het
Gins4 G A 8: 23,234,768 Q57* probably null Het
Gli1 T C 10: 127,336,527 D219G probably benign Het
Greb1 A T 12: 16,711,716 C554* probably null Het
Gtf2ird2 T C 5: 134,197,282 probably benign Het
Lck T A 4: 129,558,146 M14L probably benign Het
Megf6 A G 4: 154,252,234 D322G probably damaging Het
Olfr1272 T A 2: 90,281,919 I219F probably damaging Het
Pcdh18 A T 3: 49,754,774 D697E probably damaging Het
Pnp C T 14: 50,951,413 T221I probably damaging Het
Ppl A G 16: 5,087,889 I1514T probably damaging Het
Scnn1g A G 7: 121,766,293 M523V probably benign Het
Sema4c A G 1: 36,553,029 Y246H possibly damaging Het
Slco1a5 T A 6: 142,253,037 I301F probably benign Het
Srebf1 A G 11: 60,204,131 S446P probably benign Het
Sys1 T G 2: 164,463,305 L56R probably damaging Het
Trpc7 G T 13: 56,789,722 Y585* probably null Het
Vmn2r110 T A 17: 20,574,667 Y580F probably benign Het
Zmym6 G T 4: 127,108,706 V485F probably damaging Het
Other mutations in Ifna15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01575:Ifna15 APN 4 88557807 missense probably damaging 1.00
IGL01757:Ifna15 APN 4 88558085 missense possibly damaging 0.79
R3853:Ifna15 UTSW 4 88557809 missense probably damaging 1.00
R4356:Ifna15 UTSW 4 88557842 missense probably benign 0.09
R4357:Ifna15 UTSW 4 88557842 missense probably benign 0.09
R4358:Ifna15 UTSW 4 88557842 missense probably benign 0.09
R4359:Ifna15 UTSW 4 88557842 missense probably benign 0.09
R5038:Ifna15 UTSW 4 88558029 missense probably benign 0.03
R5372:Ifna15 UTSW 4 88558101 missense probably damaging 0.97
R6036:Ifna15 UTSW 4 88558073 missense possibly damaging 0.65
R6036:Ifna15 UTSW 4 88558073 missense possibly damaging 0.65
R7347:Ifna15 UTSW 4 88557983 missense probably damaging 1.00
R8097:Ifna15 UTSW 4 88557701 missense probably benign 0.01
R8132:Ifna15 UTSW 4 88557683 missense possibly damaging 0.60
Posted On2014-02-04