Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01824:Vmn2r110'

154617

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r110

Ensembl Gene

ENSMUSG00000091259

Gene Name

vomeronasal 2, receptor 110

Synonyms

EG224582

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.171) question?

Stock #

IGL01824

Quality Score

Status

Chromosome

Chromosomal Location

20573829-20596259 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20574667 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 580 (Y580F)

Ref Sequence

ENSEMBL: ENSMUSP00000129347 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095633] [ENSMUST00000169559]

AlphaFold

E9PWD5

Predicted Effect

probably benign
Transcript: ENSMUST00000095633

SMART Domains

Protein: ENSMUSP00000093293
Gene: ENSMUSG00000071273

Domain	Start	End	E-Value	Type
RRM	17	84	5.29e-5	SMART
low complexity region	101	113	N/A	INTRINSIC
low complexity region	119	130	N/A	INTRINSIC
low complexity region	160	175	N/A	INTRINSIC
low complexity region	179	199	N/A	INTRINSIC
RRM	207	274	1.55e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000169559
AA Change: Y580F

PolyPhen 2 Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000129347
Gene: ENSMUSG00000091259
AA Change: Y580F

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	3.1e-33	PFAM
Pfam:NCD3G	510	563	5.2e-22	PFAM
Pfam:7tm_3	594	831	4.2e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd17c	G	A	7: 84,151,289	R186C	probably benign	Het
Ankar	A	G	1: 72,651,727	V1196A	probably benign	Het
Asah1	A	T	8: 41,349,543		probably benign	Het
Chrm1	T	C	19: 8,679,130	W400R	probably damaging	Het
Cyp27a1	G	T	1: 74,735,881	E290*	probably null	Het
Dnah7a	T	C	1: 53,504,270	D2247G	probably benign	Het
Gins4	G	A	8: 23,234,768	Q57*	probably null	Het
Gli1	T	C	10: 127,336,527	D219G	probably benign	Het
Greb1	A	T	12: 16,711,716	C554*	probably null	Het
Gtf2ird2	T	C	5: 134,197,282		probably benign	Het
Ifna15	T	C	4: 88,557,783	R155G	probably benign	Het
Lck	T	A	4: 129,558,146	M14L	probably benign	Het
Megf6	A	G	4: 154,252,234	D322G	probably damaging	Het
Olfr1272	T	A	2: 90,281,919	I219F	probably damaging	Het
Pcdh18	A	T	3: 49,754,774	D697E	probably damaging	Het
Pnp	C	T	14: 50,951,413	T221I	probably damaging	Het
Ppl	A	G	16: 5,087,889	I1514T	probably damaging	Het
Scnn1g	A	G	7: 121,766,293	M523V	probably benign	Het
Sema4c	A	G	1: 36,553,029	Y246H	possibly damaging	Het
Slco1a5	T	A	6: 142,253,037	I301F	probably benign	Het
Srebf1	A	G	11: 60,204,131	S446P	probably benign	Het
Sys1	T	G	2: 164,463,305	L56R	probably damaging	Het
Trpc7	G	T	13: 56,789,722	Y585*	probably null	Het
Zmym6	G	T	4: 127,108,706	V485F	probably damaging	Het

Other mutations in Vmn2r110

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01774:Vmn2r110	APN	17	20583627	missense	probably benign	0.01
IGL01879:Vmn2r110	APN	17	20573860	missense	probably benign	0.01
IGL02168:Vmn2r110	APN	17	20583800	splice site	probably benign
IGL02178:Vmn2r110	APN	17	20584444	splice site	probably null
IGL02322:Vmn2r110	APN	17	20573935	missense	probably damaging	1.00
IGL02323:Vmn2r110	APN	17	20596137	missense	probably damaging	0.98
IGL02415:Vmn2r110	APN	17	20583771	missense	probably benign	0.03
IGL02491:Vmn2r110	APN	17	20596138	missense	probably damaging	0.99
IGL02876:Vmn2r110	APN	17	20574296	missense	probably damaging	0.98
IGL03141:Vmn2r110	APN	17	20583714	missense	possibly damaging	0.79
IGL03270:Vmn2r110	APN	17	20583516	missense	probably benign	0.00
IGL03286:Vmn2r110	APN	17	20584206	missense	possibly damaging	0.95
IGL03379:Vmn2r110	APN	17	20583644	missense	probably damaging	0.99
PIT4243001:Vmn2r110	UTSW	17	20582117	missense	probably benign	0.01
R0040:Vmn2r110	UTSW	17	20596084	missense	probably benign	0.10
R0195:Vmn2r110	UTSW	17	20574055	missense	probably benign	0.31
R0716:Vmn2r110	UTSW	17	20573903	missense	probably damaging	0.99
R1199:Vmn2r110	UTSW	17	20583263	missense	probably benign	0.03
R1767:Vmn2r110	UTSW	17	20580578	missense	possibly damaging	0.83
R2212:Vmn2r110	UTSW	17	20573947	splice site	probably null
R3056:Vmn2r110	UTSW	17	20583098	missense	probably damaging	1.00
R4093:Vmn2r110	UTSW	17	20583380	missense	possibly damaging	0.83
R4418:Vmn2r110	UTSW	17	20583689	nonsense	probably null
R4598:Vmn2r110	UTSW	17	20583767	nonsense	probably null
R4754:Vmn2r110	UTSW	17	20596196	missense	probably benign	0.00
R5283:Vmn2r110	UTSW	17	20580637	missense	probably benign	0.00
R5421:Vmn2r110	UTSW	17	20583620	missense	probably damaging	1.00
R5672:Vmn2r110	UTSW	17	20596232	missense	probably benign
R5865:Vmn2r110	UTSW	17	20584295	missense	probably benign	0.00
R6642:Vmn2r110	UTSW	17	20583517	missense	possibly damaging	0.94
R6799:Vmn2r110	UTSW	17	20583536	missense	probably benign
R7167:Vmn2r110	UTSW	17	20574179	missense	probably benign	0.01
R7291:Vmn2r110	UTSW	17	20574209	missense	probably benign	0.13
R7320:Vmn2r110	UTSW	17	20596054	missense	probably benign
R7519:Vmn2r110	UTSW	17	20584262	missense	probably benign
R8089:Vmn2r110	UTSW	17	20583545	missense	probably benign	0.00
R8234:Vmn2r110	UTSW	17	20584429	missense	probably benign	0.12
R8272:Vmn2r110	UTSW	17	20596228	missense	probably damaging	0.97
R8307:Vmn2r110	UTSW	17	20583057	missense	probably benign	0.00
R8506:Vmn2r110	UTSW	17	20584365	missense	probably benign	0.00
R8516:Vmn2r110	UTSW	17	20574613	missense	probably damaging	1.00
R8555:Vmn2r110	UTSW	17	20584356	missense	probably damaging	0.97
R8691:Vmn2r110	UTSW	17	20583142	missense	probably benign	0.19
R8859:Vmn2r110	UTSW	17	20574298	missense	probably damaging	0.99
R8935:Vmn2r110	UTSW	17	20583695	missense	probably benign	0.40
R8986:Vmn2r110	UTSW	17	20583561	missense	probably damaging	0.97
R9012:Vmn2r110	UTSW	17	20583365	missense	probably damaging	1.00
R9101:Vmn2r110	UTSW	17	20574209	missense
R9744:Vmn2r110	UTSW	17	20574586	missense	probably damaging	0.98
R9803:Vmn2r110	UTSW	17	20583468	missense	probably benign	0.00
Z1088:Vmn2r110	UTSW	17	20583680	missense	probably damaging	1.00

Posted On

2014-02-04