Incidental Mutation 'IGL01824:Trpc7'
ID 154624
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trpc7
Ensembl Gene ENSMUSG00000021541
Gene Name transient receptor potential cation channel, subfamily C, member 7
Synonyms TRP7, Trrp8
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # IGL01824
Quality Score
Status
Chromosome 13
Chromosomal Location 56920911-57043778 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 56937535 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 585 (Y585*)
Ref Sequence ENSEMBL: ENSMUSP00000133305 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022023] [ENSMUST00000109871] [ENSMUST00000151918] [ENSMUST00000174457] [ENSMUST00000173817]
AlphaFold Q9WVC5
Predicted Effect probably null
Transcript: ENSMUST00000022023
AA Change: Y640*
SMART Domains Protein: ENSMUSP00000022023
Gene: ENSMUSG00000021541
AA Change: Y640*

DomainStartEndE-ValueType
ANK 42 71 1.53e3 SMART
ANK 77 105 1.97e1 SMART
ANK 163 192 1.32e0 SMART
Pfam:TRP_2 198 260 6e-28 PFAM
transmembrane domain 352 374 N/A INTRINSIC
Pfam:Ion_trans 387 684 2.4e-34 PFAM
Pfam:PKD_channel 427 679 5.5e-14 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000109871
AA Change: Y640*
SMART Domains Protein: ENSMUSP00000105497
Gene: ENSMUSG00000021541
AA Change: Y640*

DomainStartEndE-ValueType
ANK 42 71 1.53e3 SMART
ANK 77 105 1.97e1 SMART
ANK 163 192 1.32e0 SMART
Pfam:TRP_2 198 260 1.1e-31 PFAM
transmembrane domain 352 374 N/A INTRINSIC
transmembrane domain 389 406 N/A INTRINSIC
Pfam:PKD_channel 427 679 1.6e-13 PFAM
Pfam:Ion_trans 441 672 7e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000151918
SMART Domains Protein: ENSMUSP00000119809
Gene: ENSMUSG00000021541

DomainStartEndE-ValueType
ANK 42 71 1.53e3 SMART
ANK 77 105 1.97e1 SMART
ANK 163 192 1.32e0 SMART
Pfam:TRP_2 198 260 4.6e-32 PFAM
transmembrane domain 352 374 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000173067
SMART Domains Protein: ENSMUSP00000134481
Gene: ENSMUSG00000021541

DomainStartEndE-ValueType
ANK 42 71 1.53e3 SMART
ANK 77 105 1.97e1 SMART
ANK 163 192 1.32e0 SMART
Pfam:TRP_2 198 260 5.1e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173466
SMART Domains Protein: ENSMUSP00000134285
Gene: ENSMUSG00000021541

DomainStartEndE-ValueType
ANK 42 71 1.53e3 SMART
ANK 77 105 1.97e1 SMART
ANK 163 192 1.32e0 SMART
Pfam:TRP_2 198 260 9.5e-32 PFAM
transmembrane domain 352 374 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000173513
AA Change: Y523*
SMART Domains Protein: ENSMUSP00000134662
Gene: ENSMUSG00000021541
AA Change: Y523*

DomainStartEndE-ValueType
ANK 42 71 1.53e3 SMART
ANK 77 105 1.97e1 SMART
ANK 163 192 1.32e0 SMART
Pfam:TRP_2 198 260 2.5e-31 PFAM
Pfam:PKD_channel 311 563 2.6e-13 PFAM
Pfam:Ion_trans 325 556 1.1e-35 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000174457
AA Change: Y585*
SMART Domains Protein: ENSMUSP00000133305
Gene: ENSMUSG00000021541
AA Change: Y585*

DomainStartEndE-ValueType
ANK 42 71 1.53e3 SMART
ANK 77 105 1.97e1 SMART
ANK 163 192 1.32e0 SMART
Pfam:TRP_2 198 260 2.7e-31 PFAM
Pfam:PKD_channel 372 624 3.8e-13 PFAM
Pfam:Ion_trans 386 617 1.3e-35 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000173817
AA Change: Y579*
SMART Domains Protein: ENSMUSP00000133411
Gene: ENSMUSG00000021541
AA Change: Y579*

DomainStartEndE-ValueType
ANK 42 71 1.53e3 SMART
ANK 77 105 1.97e1 SMART
ANK 163 192 1.32e0 SMART
Pfam:TRP_2 198 260 2.7e-31 PFAM
transmembrane domain 291 313 N/A INTRINSIC
transmembrane domain 328 345 N/A INTRINSIC
Pfam:PKD_channel 366 618 3.7e-13 PFAM
Pfam:Ion_trans 380 611 1.2e-35 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: The protein encoded by this gene is a member of the transient receptor potential channel family of proteins, which form six-transmembrane cation-permeable channels that are calcium permeant. Knock out mice are viable but display a reduction in the gamma wave activity that precedes seizure induction in response to a muscrarinic agonist, suggesting a functional role for this protein in initiation of seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal eye physiology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd17c G A 7: 83,800,497 (GRCm39) R186C probably benign Het
Ankar A G 1: 72,690,886 (GRCm39) V1196A probably benign Het
Asah1 A T 8: 41,802,580 (GRCm39) probably benign Het
Chrm1 T C 19: 8,656,494 (GRCm39) W400R probably damaging Het
Cyp27a1 G T 1: 74,775,040 (GRCm39) E290* probably null Het
Dnah7a T C 1: 53,543,429 (GRCm39) D2247G probably benign Het
Gins4 G A 8: 23,724,784 (GRCm39) Q57* probably null Het
Gli1 T C 10: 127,172,396 (GRCm39) D219G probably benign Het
Greb1 A T 12: 16,761,717 (GRCm39) C554* probably null Het
Gtf2ird2 T C 5: 134,226,123 (GRCm39) probably benign Het
Ifna15 T C 4: 88,476,020 (GRCm39) R155G probably benign Het
Lck T A 4: 129,451,939 (GRCm39) M14L probably benign Het
Megf6 A G 4: 154,336,691 (GRCm39) D322G probably damaging Het
Or4b1b T A 2: 90,112,263 (GRCm39) I219F probably damaging Het
Pcdh18 A T 3: 49,709,223 (GRCm39) D697E probably damaging Het
Pnp C T 14: 51,188,870 (GRCm39) T221I probably damaging Het
Ppl A G 16: 4,905,753 (GRCm39) I1514T probably damaging Het
Scnn1g A G 7: 121,365,516 (GRCm39) M523V probably benign Het
Sema4c A G 1: 36,592,110 (GRCm39) Y246H possibly damaging Het
Slco1a5 T A 6: 142,198,763 (GRCm39) I301F probably benign Het
Srebf1 A G 11: 60,094,957 (GRCm39) S446P probably benign Het
Sys1 T G 2: 164,305,225 (GRCm39) L56R probably damaging Het
Vmn2r110 T A 17: 20,794,929 (GRCm39) Y580F probably benign Het
Zmym6 G T 4: 127,002,499 (GRCm39) V485F probably damaging Het
Other mutations in Trpc7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00538:Trpc7 APN 13 56,921,622 (GRCm39) missense possibly damaging 0.64
IGL00809:Trpc7 APN 13 56,970,301 (GRCm39) missense probably benign 0.00
IGL01011:Trpc7 APN 13 56,952,353 (GRCm39) missense probably damaging 1.00
IGL01517:Trpc7 APN 13 57,008,878 (GRCm39) missense probably damaging 1.00
IGL02055:Trpc7 APN 13 57,035,357 (GRCm39) missense probably benign 0.13
IGL02267:Trpc7 APN 13 57,008,743 (GRCm39) missense probably damaging 1.00
IGL02323:Trpc7 APN 13 56,931,564 (GRCm39) missense possibly damaging 0.91
IGL02451:Trpc7 APN 13 56,970,274 (GRCm39) missense probably damaging 0.98
IGL02635:Trpc7 APN 13 56,923,981 (GRCm39) missense probably damaging 1.00
IGL03335:Trpc7 APN 13 57,035,504 (GRCm39) missense probably damaging 1.00
PIT4305001:Trpc7 UTSW 13 57,035,321 (GRCm39) missense probably benign 0.00
R0217:Trpc7 UTSW 13 56,937,581 (GRCm39) nonsense probably null
R0611:Trpc7 UTSW 13 57,035,636 (GRCm39) missense probably damaging 1.00
R0919:Trpc7 UTSW 13 56,970,462 (GRCm39) splice site probably benign
R1235:Trpc7 UTSW 13 57,035,352 (GRCm39) missense probably damaging 1.00
R1751:Trpc7 UTSW 13 56,923,956 (GRCm39) missense probably damaging 1.00
R4324:Trpc7 UTSW 13 57,035,169 (GRCm39) missense probably damaging 0.99
R4649:Trpc7 UTSW 13 57,035,367 (GRCm39) missense probably damaging 1.00
R4731:Trpc7 UTSW 13 56,952,366 (GRCm39) missense probably damaging 1.00
R5379:Trpc7 UTSW 13 56,952,363 (GRCm39) missense probably damaging 1.00
R5834:Trpc7 UTSW 13 56,923,971 (GRCm39) missense probably damaging 1.00
R5985:Trpc7 UTSW 13 56,958,358 (GRCm39) missense probably damaging 0.96
R6244:Trpc7 UTSW 13 56,921,705 (GRCm39) missense probably damaging 1.00
R6599:Trpc7 UTSW 13 56,958,193 (GRCm39) splice site probably null
R6778:Trpc7 UTSW 13 56,952,500 (GRCm39) missense probably damaging 1.00
R7140:Trpc7 UTSW 13 56,937,487 (GRCm39) nonsense probably null
R7150:Trpc7 UTSW 13 56,931,509 (GRCm39) missense probably benign 0.00
R7156:Trpc7 UTSW 13 56,937,579 (GRCm39) missense possibly damaging 0.61
R7238:Trpc7 UTSW 13 56,974,710 (GRCm39) missense probably benign 0.17
R7716:Trpc7 UTSW 13 56,937,573 (GRCm39) missense probably damaging 1.00
R7739:Trpc7 UTSW 13 56,921,579 (GRCm39) makesense probably null
R8114:Trpc7 UTSW 13 56,952,411 (GRCm39) missense probably benign 0.14
R8143:Trpc7 UTSW 13 56,930,362 (GRCm39) missense probably benign 0.01
R8179:Trpc7 UTSW 13 57,035,693 (GRCm39) missense probably damaging 1.00
R8204:Trpc7 UTSW 13 56,931,609 (GRCm39) missense probably benign 0.06
R8262:Trpc7 UTSW 13 56,937,602 (GRCm39) missense probably benign 0.32
R8325:Trpc7 UTSW 13 56,952,524 (GRCm39) missense probably damaging 1.00
R8353:Trpc7 UTSW 13 56,970,372 (GRCm39) missense probably benign 0.04
R8414:Trpc7 UTSW 13 56,970,282 (GRCm39) missense probably benign 0.01
R8453:Trpc7 UTSW 13 56,970,372 (GRCm39) missense probably benign 0.04
R8815:Trpc7 UTSW 13 56,970,312 (GRCm39) missense possibly damaging 0.73
R8867:Trpc7 UTSW 13 57,008,746 (GRCm39) missense probably benign 0.00
R8990:Trpc7 UTSW 13 56,952,485 (GRCm39) missense possibly damaging 0.91
R9038:Trpc7 UTSW 13 57,035,886 (GRCm39) missense probably benign 0.00
R9444:Trpc7 UTSW 13 56,923,968 (GRCm39) missense possibly damaging 0.79
Z1177:Trpc7 UTSW 13 56,970,245 (GRCm39) missense probably damaging 0.99
Z1177:Trpc7 UTSW 13 56,958,257 (GRCm39) missense probably benign 0.00
Posted On 2014-02-04