Incidental Mutation 'IGL01825:Scgb2b24'
ID154659
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Scgb2b24
Ensembl Gene ENSMUSG00000046438
Gene Namesecretoglobin, family 2B, member 24
SynonymsC2b, Abpbg24, Abpz, Scgb2b3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #IGL01825
Quality Score
Status
Chromosome7
Chromosomal Location33737190-33739312 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 33739227 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Lysine at position 20 (T20K)
Ref Sequence ENSEMBL: ENSMUSP00000052456 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055444] [ENSMUST00000108087]
Predicted Effect probably damaging
Transcript: ENSMUST00000055444
AA Change: T20K

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000052456
Gene: ENSMUSG00000046438
AA Change: T20K

DomainStartEndE-ValueType
low complexity region 5 11 N/A INTRINSIC
Pfam:Feld-I_B 24 90 5.9e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108087
SMART Domains Protein: ENSMUSP00000103722
Gene: ENSMUSG00000078753

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
UTG 23 92 4.95e-15 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam30 A G 3: 98,161,901 E222G probably damaging Het
Aftph T A 11: 20,726,569 I347F possibly damaging Het
Braf T C 6: 39,639,590 D549G probably damaging Het
Cnbd2 T A 2: 156,338,709 L142Q probably damaging Het
Ctbp1 C T 5: 33,259,133 probably null Het
Cuta T C 17: 26,938,464 I98V probably benign Het
Dip2a A T 10: 76,272,680 C1226* probably null Het
Dnah6 T C 6: 73,065,776 E3221G probably damaging Het
Grm3 A G 5: 9,511,600 L750P probably damaging Het
Herc1 T C 9: 66,399,807 Y970H probably benign Het
Hnrnpr T A 4: 136,339,539 Y470* probably null Het
Kmt2c T A 5: 25,310,596 I2750F probably damaging Het
Lrig3 A T 10: 126,010,017 T772S probably damaging Het
Mthfd2 T C 6: 83,310,511 T191A probably benign Het
Olfr506 C A 7: 108,613,054 T249K probably damaging Het
Pfkp A T 13: 6,620,978 N175K probably damaging Het
Plcz1 T C 6: 140,003,916 D451G probably benign Het
Plxna2 T A 1: 194,788,902 C994S probably damaging Het
Ptdss1 T C 13: 66,987,822 I381T probably benign Het
Slc23a1 A T 18: 35,624,203 W272R probably damaging Het
Tcf20 G A 15: 82,852,966 T1428I probably benign Het
Tnfsf9 A G 17: 57,107,335 D254G possibly damaging Het
Ttc4 C T 4: 106,671,619 probably null Het
Xdh A G 17: 73,891,245 Y1216H probably damaging Het
Zbtb21 G T 16: 97,952,689 N159K possibly damaging Het
Other mutations in Scgb2b24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02328:Scgb2b24 APN 7 33738625 splice site probably benign
PIT4618001:Scgb2b24 UTSW 7 33738611 missense probably damaging 0.96
R3441:Scgb2b24 UTSW 7 33738600 missense probably damaging 1.00
R5874:Scgb2b24 UTSW 7 33737405 missense probably damaging 0.99
R6572:Scgb2b24 UTSW 7 33738477 missense probably damaging 1.00
R6800:Scgb2b24 UTSW 7 33738469 missense probably benign 0.01
R7431:Scgb2b24 UTSW 7 33739249 missense probably benign 0.13
R8096:Scgb2b24 UTSW 7 33739221 splice site probably null
R8458:Scgb2b24 UTSW 7 33737354 missense probably benign 0.00
Posted On2014-02-04