Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01826:Tas2r119'

154664

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r119

Ensembl Gene

ENSMUSG00000045267

Gene Name

taste receptor, type 2, member 119

Synonyms

mGR19, T2R19, mt2r19, Tas2r19

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01826

Quality Score

Status

Chromosome

Chromosomal Location

32177289-32178294 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 32177402 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Methionine at position 38 (K38M)

Ref Sequence

ENSEMBL: ENSMUSP00000050277 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057633]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000057633
AA Change: K38M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000050277
Gene: ENSMUSG00000045267
AA Change: K38M

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	293	1.1e-90	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930432K21Rik	T	C	8: 84,166,672	V156A	probably benign	Het
Abcc8	T	A	7: 46,124,849	D769V	probably benign	Het
Afm	T	A	5: 90,524,928		probably benign	Het
Ago3	A	G	4: 126,403,282	S181P	probably damaging	Het
Ccdc114	T	A	7: 45,948,386	S573R	possibly damaging	Het
Ccm2l	C	A	2: 153,067,933		probably benign	Het
Clhc1	A	G	11: 29,553,765		probably null	Het
Ear6	A	G	14: 51,854,265	I90V	probably benign	Het
Fsip2	T	G	2: 82,982,639	S3101A	probably benign	Het
Gpsm1	C	A	2: 26,326,302	H384N	probably damaging	Het
Itgal	A	G	7: 127,302,146	I235V	probably benign	Het
Lrp1b	C	A	2: 41,449,234	G752C	probably damaging	Het
Ltbp1	A	G	17: 75,292,840	D659G	possibly damaging	Het
Plb1	A	C	5: 32,281,145	D208A	probably damaging	Het
Plce1	T	A	19: 38,739,238		probably benign	Het
Stim1	A	G	7: 102,427,075		probably benign	Het
Sult4a1	A	T	15: 84,090,046	S141T	probably damaging	Het
Usp34	G	A	11: 23,436,020	R2149H	probably damaging	Het
Zfp451	G	A	1: 33,782,162	T203M	probably damaging	Het

Other mutations in Tas2r119

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00577:Tas2r119	APN	15	32177453	missense	probably damaging	0.97
IGL01522:Tas2r119	APN	15	32178193	missense	probably benign	0.15
IGL01548:Tas2r119	APN	15	32177977	missense	probably damaging	1.00
IGL02432:Tas2r119	APN	15	32177707	missense	probably benign	0.06
IGL02585:Tas2r119	APN	15	32177533	missense	probably benign	0.04
R2248:Tas2r119	UTSW	15	32178151	missense	possibly damaging	0.51
R2432:Tas2r119	UTSW	15	32178019	missense	possibly damaging	0.80
R5098:Tas2r119	UTSW	15	32178082	missense	probably benign	0.03
R5624:Tas2r119	UTSW	15	32177968	missense	probably damaging	1.00
R5819:Tas2r119	UTSW	15	32177306	missense	probably damaging	1.00
R5901:Tas2r119	UTSW	15	32177786	missense	possibly damaging	0.84
R6363:Tas2r119	UTSW	15	32177888	missense	possibly damaging	0.91
R6495:Tas2r119	UTSW	15	32177530	missense	probably benign
R6521:Tas2r119	UTSW	15	32178173	missense	probably damaging	1.00
R7574:Tas2r119	UTSW	15	32178133	missense	probably damaging	1.00
R9004:Tas2r119	UTSW	15	32177963	missense	probably damaging	1.00
R9015:Tas2r119	UTSW	15	32178080	missense	probably damaging	1.00
R9193:Tas2r119	UTSW	15	32177786	missense	probably benign	0.02
X0063:Tas2r119	UTSW	15	32178155	missense	possibly damaging	0.95

Posted On

2014-02-04