Incidental Mutation 'IGL01826:Tas2r119'
ID 154664
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r119
Ensembl Gene ENSMUSG00000045267
Gene Name taste receptor, type 2, member 119
Synonyms mGR19, T2R19, mt2r19, Tas2r19
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01826
Quality Score
Status
Chromosome 15
Chromosomal Location 32177289-32178294 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 32177402 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Lysine to Methionine at position 38 (K38M)
Ref Sequence ENSEMBL: ENSMUSP00000050277 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057633]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000057633
AA Change: K38M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000050277
Gene: ENSMUSG00000045267
AA Change: K38M

DomainStartEndE-ValueType
Pfam:TAS2R 1 293 1.1e-90 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432K21Rik T C 8: 84,166,672 V156A probably benign Het
Abcc8 T A 7: 46,124,849 D769V probably benign Het
Afm T A 5: 90,524,928 probably benign Het
Ago3 A G 4: 126,403,282 S181P probably damaging Het
Ccdc114 T A 7: 45,948,386 S573R possibly damaging Het
Ccm2l C A 2: 153,067,933 probably benign Het
Clhc1 A G 11: 29,553,765 probably null Het
Ear6 A G 14: 51,854,265 I90V probably benign Het
Fsip2 T G 2: 82,982,639 S3101A probably benign Het
Gpsm1 C A 2: 26,326,302 H384N probably damaging Het
Itgal A G 7: 127,302,146 I235V probably benign Het
Lrp1b C A 2: 41,449,234 G752C probably damaging Het
Ltbp1 A G 17: 75,292,840 D659G possibly damaging Het
Plb1 A C 5: 32,281,145 D208A probably damaging Het
Plce1 T A 19: 38,739,238 probably benign Het
Stim1 A G 7: 102,427,075 probably benign Het
Sult4a1 A T 15: 84,090,046 S141T probably damaging Het
Usp34 G A 11: 23,436,020 R2149H probably damaging Het
Zfp451 G A 1: 33,782,162 T203M probably damaging Het
Other mutations in Tas2r119
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00577:Tas2r119 APN 15 32177453 missense probably damaging 0.97
IGL01522:Tas2r119 APN 15 32178193 missense probably benign 0.15
IGL01548:Tas2r119 APN 15 32177977 missense probably damaging 1.00
IGL02432:Tas2r119 APN 15 32177707 missense probably benign 0.06
IGL02585:Tas2r119 APN 15 32177533 missense probably benign 0.04
R2248:Tas2r119 UTSW 15 32178151 missense possibly damaging 0.51
R2432:Tas2r119 UTSW 15 32178019 missense possibly damaging 0.80
R5098:Tas2r119 UTSW 15 32178082 missense probably benign 0.03
R5624:Tas2r119 UTSW 15 32177968 missense probably damaging 1.00
R5819:Tas2r119 UTSW 15 32177306 missense probably damaging 1.00
R5901:Tas2r119 UTSW 15 32177786 missense possibly damaging 0.84
R6363:Tas2r119 UTSW 15 32177888 missense possibly damaging 0.91
R6495:Tas2r119 UTSW 15 32177530 missense probably benign
R6521:Tas2r119 UTSW 15 32178173 missense probably damaging 1.00
R7574:Tas2r119 UTSW 15 32178133 missense probably damaging 1.00
R9004:Tas2r119 UTSW 15 32177963 missense probably damaging 1.00
R9015:Tas2r119 UTSW 15 32178080 missense probably damaging 1.00
R9193:Tas2r119 UTSW 15 32177786 missense probably benign 0.02
X0063:Tas2r119 UTSW 15 32178155 missense possibly damaging 0.95
Posted On 2014-02-04