Incidental Mutation 'IGL01830:Gip'
ID 154755
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gip
Ensembl Gene ENSMUSG00000014351
Gene Name gastric inhibitory polypeptide
Synonyms glucose-dependent insulinotropic polypeptide
Accession Numbers
Essential gene? Not available question?
Stock # IGL01830
Quality Score
Status
Chromosome 11
Chromosomal Location 95915371-95921657 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 95919550 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Serine at position 91 (L91S)
Ref Sequence ENSEMBL: ENSMUSP00000099446 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103156] [ENSMUST00000103157]
AlphaFold P48756
Predicted Effect possibly damaging
Transcript: ENSMUST00000103156
AA Change: L91S

PolyPhen 2 Score 0.629 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000099445
Gene: ENSMUSG00000014351
AA Change: L91S

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
GLUCA 44 70 5.96e-9 SMART
low complexity region 113 124 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000103157
AA Change: L91S

PolyPhen 2 Score 0.629 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000099446
Gene: ENSMUSG00000014351
AA Change: L91S

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
GLUCA 44 70 5.96e-9 SMART
low complexity region 113 124 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183609
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes an incretin hormone that belongs to the glucagon superfamily. The encoded preproprotein undergoes proteolytic processing to generate mature peptides that function as potent stimulators of insulin secretion and inhibit gastric acid secretion. Transgenic mice overexpressing the encoded protein exhibit a significant increase in the expression of markers of bone formation, a decrease in the expression of markers of bone resorption and, an increase in the bone mass. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit obesity and insulin hypersecretion but normal K-cell number when fed a high fat diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahsg C A 16: 22,717,779 (GRCm39) P252Q probably damaging Het
Anks4b T A 7: 119,773,219 (GRCm39) N26K probably damaging Het
Arrdc5 C T 17: 56,601,652 (GRCm39) V158I probably damaging Het
Catsper2 T C 2: 121,237,843 (GRCm39) D179G probably damaging Het
Cd44 T C 2: 102,672,603 (GRCm39) probably benign Het
Ceacam3 T A 7: 16,888,925 (GRCm39) D231E possibly damaging Het
Cep57l1 C T 10: 41,604,649 (GRCm39) C160Y probably benign Het
Chek2 T A 5: 111,021,374 (GRCm39) L528Q probably benign Het
Ciita T C 16: 10,338,915 (GRCm39) L973P probably damaging Het
Dock2 A T 11: 34,582,744 (GRCm39) L637* probably null Het
Fsip2 A C 2: 82,815,273 (GRCm39) I3669L probably benign Het
Gapvd1 A G 2: 34,578,968 (GRCm39) V1218A probably benign Het
Gp2 T C 7: 119,050,765 (GRCm39) D322G probably damaging Het
Ift172 A G 5: 31,442,636 (GRCm39) V177A probably damaging Het
Kng2 T C 16: 22,806,801 (GRCm39) D466G probably damaging Het
Lpar5 G A 6: 125,058,785 (GRCm39) A169T probably benign Het
Med13 C T 11: 86,179,754 (GRCm39) probably benign Het
Meiob T A 17: 25,054,105 (GRCm39) C391S probably benign Het
Mgat5 A G 1: 127,339,869 (GRCm39) T417A probably damaging Het
Myo1b A T 1: 51,836,624 (GRCm39) L279* probably null Het
Myo1g T A 11: 6,464,522 (GRCm39) K513* probably null Het
Nxpe2 A T 9: 48,237,794 (GRCm39) S154T probably damaging Het
Ogn C T 13: 49,762,723 (GRCm39) Q22* probably null Het
Or4c12 A G 2: 89,773,775 (GRCm39) L228S probably benign Het
Pacs2 A T 12: 113,020,574 (GRCm39) K316* probably null Het
Pelo T A 13: 115,225,131 (GRCm39) I365F probably damaging Het
Phf3 G A 1: 30,853,148 (GRCm39) Q1021* probably null Het
Pik3r4 A G 9: 105,522,154 (GRCm39) D240G probably damaging Het
Pknox1 T C 17: 31,814,284 (GRCm39) M203T probably benign Het
Pld1 T C 3: 28,102,153 (GRCm39) probably benign Het
Rabgef1 G T 5: 130,240,907 (GRCm39) C342F possibly damaging Het
Rbm19 A C 5: 120,262,760 (GRCm39) K307T possibly damaging Het
Sdcbp2 T A 2: 151,431,494 (GRCm39) I289N probably damaging Het
Slc5a12 G A 2: 110,428,151 (GRCm39) G69R probably damaging Het
Spag1 C A 15: 36,221,705 (GRCm39) S599R probably benign Het
Ubr4 A T 4: 139,199,811 (GRCm39) D4565V probably damaging Het
Usp34 G A 11: 23,386,020 (GRCm39) R2149H probably damaging Het
Vmn1r225 T C 17: 20,722,717 (GRCm39) S53P probably damaging Het
Xrcc1 T A 7: 24,272,767 (GRCm39) probably benign Het
Other mutations in Gip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01012:Gip APN 11 95,916,285 (GRCm39) missense probably benign
Posted On 2014-02-04