Incidental Mutation 'R0028:Fyb'
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ID15479
Institutional Source Beutler Lab
Gene Symbol Fyb
Ensembl Gene ENSMUSG00000022148
Gene NameFYN binding protein
SynonymsB630013F22Rik, ADAP, FYB-120/130
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R0028 (G1)
Quality Score
Status Validated
Chromosome15
Chromosomal Location6522853-6663313 bp(+) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) A to G at 6644914 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000090461]
Predicted Effect probably benign
Transcript: ENSMUST00000090461
SMART Domains Protein: ENSMUSP00000087947
Gene: ENSMUSG00000022148

DomainStartEndE-ValueType
low complexity region 67 85 N/A INTRINSIC
low complexity region 149 160 N/A INTRINSIC
low complexity region 236 246 N/A INTRINSIC
low complexity region 335 353 N/A INTRINSIC
low complexity region 371 409 N/A INTRINSIC
low complexity region 440 451 N/A INTRINSIC
low complexity region 457 494 N/A INTRINSIC
SH3 502 559 1.24e-3 SMART
low complexity region 611 626 N/A INTRINSIC
Pfam:hSH3 731 819 2.9e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159604
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160698
Predicted Effect probably benign
Transcript: ENSMUST00000163073
SMART Domains Protein: ENSMUSP00000123895
Gene: ENSMUSG00000022148

DomainStartEndE-ValueType
low complexity region 12 27 N/A INTRINSIC
Pfam:hSH3 86 170 4.1e-42 PFAM
Coding Region Coverage
  • 1x: 80.7%
  • 3x: 72.7%
  • 10x: 50.3%
  • 20x: 30.1%
Validation Efficiency 96% (74/77)
MGI Phenotype FUNCTION: The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased T cell proliferation, thymocytes and platelet counts and decreased TCR-stimulated leukocyte adhesion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T C 17: 24,377,724 F384L probably benign Het
AC159748.1 T C 10: 5,542,006 silent Het
Adamts12 C T 15: 11,215,624 R244C probably damaging Het
Bms1 T C 6: 118,416,519 I131V probably benign Het
Ccdc107 A G 4: 43,495,549 T151A probably benign Het
Col1a2 G A 6: 4,518,822 probably benign Het
Col4a4 A G 1: 82,487,510 probably null Het
Creb1 A G 1: 64,570,148 D126G probably damaging Het
Ddb1 T A 19: 10,619,246 V443E probably damaging Het
Dnmt3a T A 12: 3,900,337 S634T probably damaging Het
Fras1 A C 5: 96,677,316 N1455T probably benign Het
Gpr141 C T 13: 19,752,429 V59M probably damaging Het
Ikbke T C 1: 131,272,184 I222V possibly damaging Het
Macf1 A T 4: 123,382,102 H6222Q probably damaging Het
Mapk8ip3 C T 17: 24,904,897 probably benign Het
Phactr1 A T 13: 43,057,179 D74V probably damaging Het
Prickle2 T C 6: 92,422,342 I185V probably benign Het
Rnasel A T 1: 153,754,719 D327V probably benign Het
Slc25a13 T C 6: 6,181,047 N46D probably benign Het
Slc28a2 T A 2: 122,451,602 F261L probably damaging Het
Slc6a15 A T 10: 103,416,680 Y568F probably benign Het
Slc7a1 A G 5: 148,335,511 V452A probably benign Het
Tectb T C 19: 55,194,677 probably null Het
Tmem92 C T 11: 94,778,952 V118I possibly damaging Het
Tmf1 T C 6: 97,158,098 E985G probably damaging Het
Traf5 T A 1: 192,074,121 probably benign Het
Trip11 T C 12: 101,884,757 E731G probably damaging Het
Unc5a A G 13: 55,003,913 S50G possibly damaging Het
Wrnip1 T C 13: 32,820,297 L517P probably damaging Het
Zfp202 T A 9: 40,211,752 H603Q probably damaging Het
Other mutations in Fyb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00417:Fyb APN 15 6580777 missense probably damaging 0.99
IGL00801:Fyb APN 15 6644824 missense possibly damaging 0.86
IGL00974:Fyb APN 15 6642585 unclassified probably benign
IGL01377:Fyb APN 15 6580320 missense probably benign 0.01
IGL01982:Fyb APN 15 6580177 missense probably null 0.99
IGL02173:Fyb APN 15 6580695 missense probably benign 0.00
IGL02177:Fyb APN 15 6658566 critical splice donor site probably null
IGL02345:Fyb APN 15 6619662 missense possibly damaging 0.94
IGL02695:Fyb APN 15 6580921 missense probably damaging 1.00
IGL02820:Fyb APN 15 6658559 missense possibly damaging 0.65
IGL02867:Fyb APN 15 6580046 missense probably damaging 1.00
luegner UTSW 15 6580869 nonsense probably null
P0023:Fyb UTSW 15 6651854 missense probably damaging 1.00
R0364:Fyb UTSW 15 6580791 missense probably damaging 1.00
R0507:Fyb UTSW 15 6634816 missense probably benign 0.39
R0588:Fyb UTSW 15 6580459 missense probably benign 0.03
R0742:Fyb UTSW 15 6634816 missense probably benign 0.39
R0930:Fyb UTSW 15 6638828 missense probably damaging 1.00
R1184:Fyb UTSW 15 6638900 missense probably damaging 1.00
R1446:Fyb UTSW 15 6652466 missense probably benign 0.02
R1481:Fyb UTSW 15 6619647 missense probably benign 0.01
R1711:Fyb UTSW 15 6580479 missense probably damaging 1.00
R2041:Fyb UTSW 15 6644787 missense possibly damaging 0.78
R2176:Fyb UTSW 15 6579954 missense probably damaging 1.00
R2224:Fyb UTSW 15 6652383 missense probably damaging 1.00
R2372:Fyb UTSW 15 6651907 splice site probably benign
R3236:Fyb UTSW 15 6630116 missense probably damaging 0.96
R4117:Fyb UTSW 15 6630116 missense probably damaging 0.96
R4181:Fyb UTSW 15 6580923 missense probably benign 0.00
R4322:Fyb UTSW 15 6580819 missense possibly damaging 0.84
R4952:Fyb UTSW 15 6638811 missense probably damaging 1.00
R4981:Fyb UTSW 15 6646611 splice site probably benign
R5055:Fyb UTSW 15 6585149 unclassified probably benign
R5368:Fyb UTSW 15 6580678 unclassified probably null
R5719:Fyb UTSW 15 6580869 nonsense probably null
R5822:Fyb UTSW 15 6663226 unclassified probably benign
R6064:Fyb UTSW 15 6638868 missense probably damaging 1.00
R6929:Fyb UTSW 15 6638907 missense probably damaging 1.00
Z1088:Fyb UTSW 15 6658540 missense probably benign 0.41
Posted On2012-12-21