Incidental Mutation 'IGL01832:Ccdc15'
ID 154793
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccdc15
Ensembl Gene ENSMUSG00000034303
Gene Name coiled-coil domain containing 15
Synonyms A630039F14Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.119) question?
Stock # IGL01832
Quality Score
Status
Chromosome 9
Chromosomal Location 37187131-37259728 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 37222640 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Tryptophan at position 585 (R585W)
Ref Sequence ENSEMBL: ENSMUSP00000150207 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037275] [ENSMUST00000213633] [ENSMUST00000215116]
AlphaFold Q8C9M2
Predicted Effect possibly damaging
Transcript: ENSMUST00000037275
AA Change: R598W

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000036784
Gene: ENSMUSG00000034303
AA Change: R598W

DomainStartEndE-ValueType
low complexity region 80 92 N/A INTRINSIC
low complexity region 95 109 N/A INTRINSIC
coiled coil region 173 202 N/A INTRINSIC
coiled coil region 652 686 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000213633
AA Change: R585W

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
Predicted Effect probably benign
Transcript: ENSMUST00000215116
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216060
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217440
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(2) : Gene trapped(2)

Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap10 G A 8: 77,985,758 (GRCm39) T681I probably benign Het
Atg4b T C 1: 93,713,626 (GRCm39) probably benign Het
Atp10b T A 11: 43,125,262 (GRCm39) M1076K probably damaging Het
Atp23 A T 10: 126,730,214 (GRCm39) N111K probably damaging Het
Atxn2 C A 5: 121,944,331 (GRCm39) Y72* probably null Het
C1qtnf12 A G 4: 156,050,323 (GRCm39) D220G probably damaging Het
C2cd3 A T 7: 100,076,421 (GRCm39) T1171S possibly damaging Het
Cep152 A C 2: 125,460,414 (GRCm39) Y179* probably null Het
Cpa2 T C 6: 30,551,998 (GRCm39) S242P probably benign Het
Ctps2 G T X: 161,719,699 (GRCm39) probably benign Het
Cttnbp2nl A G 3: 104,918,544 (GRCm39) S99P probably damaging Het
Ddx20 A G 3: 105,586,327 (GRCm39) S673P probably damaging Het
Erbb4 T C 1: 68,293,725 (GRCm39) K722R possibly damaging Het
Ercc8 A G 13: 108,305,993 (GRCm39) T123A probably damaging Het
Ermard T C 17: 15,280,111 (GRCm39) V87A probably damaging Het
Fkbp8 A G 8: 70,984,195 (GRCm39) H182R probably benign Het
Gab2 T C 7: 96,953,445 (GRCm39) L606P probably damaging Het
Gls C T 1: 52,207,568 (GRCm39) probably null Het
Hook3 A T 8: 26,562,393 (GRCm39) M224K possibly damaging Het
Itga5 T A 15: 103,264,376 (GRCm39) K298* probably null Het
Itprid2 G A 2: 79,481,762 (GRCm39) V481M possibly damaging Het
Lrrc74a C A 12: 86,808,488 (GRCm39) T422K probably benign Het
Myh9 A C 15: 77,675,953 (GRCm39) D244E probably benign Het
Ndrg4 A G 8: 96,439,947 (GRCm39) E349G probably damaging Het
Or9m2 T A 2: 87,820,513 (GRCm39) D19E probably benign Het
Otop2 T C 11: 115,217,769 (GRCm39) S202P probably benign Het
Plppr2 C A 9: 21,854,742 (GRCm39) R138S possibly damaging Het
Prkaca A C 8: 84,717,366 (GRCm39) K206N probably damaging Het
Ptpro C T 6: 137,370,666 (GRCm39) T589I possibly damaging Het
Ptprq A G 10: 107,401,700 (GRCm39) probably null Het
Slc16a5 T C 11: 115,355,827 (GRCm39) V96A probably benign Het
Tcerg1 A G 18: 42,707,620 (GRCm39) K1047E probably damaging Het
Tinag T C 9: 76,939,038 (GRCm39) K147E probably benign Het
Urgcp T C 11: 5,667,325 (GRCm39) T338A probably damaging Het
Wdr74 C T 19: 8,717,302 (GRCm39) R299C probably damaging Het
Zzef1 C T 11: 72,765,892 (GRCm39) S1473L probably damaging Het
Other mutations in Ccdc15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00503:Ccdc15 APN 9 37,231,769 (GRCm39) missense probably damaging 1.00
IGL00823:Ccdc15 APN 9 37,231,709 (GRCm39) missense probably benign 0.01
IGL00979:Ccdc15 APN 9 37,227,786 (GRCm39) missense probably benign 0.44
IGL01380:Ccdc15 APN 9 37,187,853 (GRCm39) utr 3 prime probably benign
IGL01845:Ccdc15 APN 9 37,226,532 (GRCm39) nonsense probably null
IGL02375:Ccdc15 APN 9 37,215,628 (GRCm39) missense probably damaging 0.99
F6893:Ccdc15 UTSW 9 37,226,936 (GRCm39) missense probably damaging 0.97
FR4304:Ccdc15 UTSW 9 37,226,453 (GRCm39) frame shift probably null
FR4449:Ccdc15 UTSW 9 37,226,454 (GRCm39) frame shift probably null
R1743:Ccdc15 UTSW 9 37,188,773 (GRCm39) nonsense probably null
R1848:Ccdc15 UTSW 9 37,253,866 (GRCm39) missense probably benign 0.00
R1968:Ccdc15 UTSW 9 37,259,091 (GRCm39) missense probably benign 0.05
R2006:Ccdc15 UTSW 9 37,226,768 (GRCm39) missense possibly damaging 0.91
R2372:Ccdc15 UTSW 9 37,226,801 (GRCm39) missense possibly damaging 0.64
R2932:Ccdc15 UTSW 9 37,226,954 (GRCm39) missense probably benign 0.00
R3962:Ccdc15 UTSW 9 37,231,782 (GRCm39) missense probably damaging 1.00
R5585:Ccdc15 UTSW 9 37,188,699 (GRCm39) missense probably benign 0.00
R5919:Ccdc15 UTSW 9 37,231,692 (GRCm39) critical splice donor site probably null
R6000:Ccdc15 UTSW 9 37,227,060 (GRCm39) missense probably benign 0.00
R6198:Ccdc15 UTSW 9 37,225,581 (GRCm39) critical splice donor site probably null
R6476:Ccdc15 UTSW 9 37,253,715 (GRCm39) missense probably benign 0.04
R7098:Ccdc15 UTSW 9 37,255,256 (GRCm39) missense probably damaging 1.00
R7485:Ccdc15 UTSW 9 37,226,574 (GRCm39) missense probably benign
R7548:Ccdc15 UTSW 9 37,188,723 (GRCm39) missense probably benign 0.45
R7627:Ccdc15 UTSW 9 37,253,698 (GRCm39) missense unknown
R7807:Ccdc15 UTSW 9 37,226,678 (GRCm39) missense probably benign 0.07
R8157:Ccdc15 UTSW 9 37,226,753 (GRCm39) missense probably benign
R8230:Ccdc15 UTSW 9 37,226,555 (GRCm39) missense probably benign
R9492:Ccdc15 UTSW 9 37,215,665 (GRCm39) missense probably damaging 1.00
R9645:Ccdc15 UTSW 9 37,227,083 (GRCm39) missense probably benign 0.00
Posted On 2014-02-04