Incidental Mutation 'IGL01832:Lrrc74a'
ID154813
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc74a
Ensembl Gene ENSMUSG00000059114
Gene Nameleucine rich repeat containing 74A
SynonymsLrrc74, Gm6772
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL01832
Quality Score
Status
Chromosome12
Chromosomal Location86734369-86763797 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 86761714 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Lysine at position 422 (T422K)
Ref Sequence ENSEMBL: ENSMUSP00000152661 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095527] [ENSMUST00000222180] [ENSMUST00000223308]
Predicted Effect probably benign
Transcript: ENSMUST00000095527
AA Change: T422K

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000093183
Gene: ENSMUSG00000059114
AA Change: T422K

DomainStartEndE-ValueType
Blast:LRR 87 116 9e-7 BLAST
LRR 117 144 4.17e-3 SMART
LRR 145 172 3.16e-3 SMART
LRR 174 201 1.92e-2 SMART
LRR 202 229 3.07e-1 SMART
LRR 230 257 1.03e-2 SMART
LRR 258 285 1.64e-1 SMART
LRR 286 313 2.03e0 SMART
LRR 314 341 1.11e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000222180
Predicted Effect probably benign
Transcript: ENSMUST00000223308
AA Change: T422K

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap10 G A 8: 77,259,129 T681I probably benign Het
Atg4b T C 1: 93,785,904 probably benign Het
Atp10b T A 11: 43,234,435 M1076K probably damaging Het
Atp23 A T 10: 126,894,345 N111K probably damaging Het
Atxn2 C A 5: 121,806,268 Y72* probably null Het
C1qtnf12 A G 4: 155,965,866 D220G probably damaging Het
C2cd3 A T 7: 100,427,214 T1171S possibly damaging Het
Ccdc15 G A 9: 37,311,344 R585W probably damaging Het
Cep152 A C 2: 125,618,494 Y179* probably null Het
Cpa2 T C 6: 30,551,999 S242P probably benign Het
Ctps2 G T X: 162,936,703 probably benign Het
Cttnbp2nl A G 3: 105,011,228 S99P probably damaging Het
Ddx20 A G 3: 105,679,011 S673P probably damaging Het
Erbb4 T C 1: 68,254,566 K722R possibly damaging Het
Ercc8 A G 13: 108,169,459 T123A probably damaging Het
Ermard T C 17: 15,059,849 V87A probably damaging Het
Fkbp8 A G 8: 70,531,545 H182R probably benign Het
Gab2 T C 7: 97,304,238 L606P probably damaging Het
Gls C T 1: 52,168,409 probably null Het
Hook3 A T 8: 26,072,365 M224K possibly damaging Het
Itga5 T A 15: 103,355,949 K298* probably null Het
Myh9 A C 15: 77,791,753 D244E probably benign Het
Ndrg4 A G 8: 95,713,319 E349G probably damaging Het
Olfr1158 T A 2: 87,990,169 D19E probably benign Het
Otop2 T C 11: 115,326,943 S202P probably benign Het
Plppr2 C A 9: 21,943,446 R138S possibly damaging Het
Prkaca A C 8: 83,990,737 K206N probably damaging Het
Ptpro C T 6: 137,393,668 T589I possibly damaging Het
Ptprq A G 10: 107,565,839 probably null Het
Slc16a5 T C 11: 115,465,001 V96A probably benign Het
Ssfa2 G A 2: 79,651,418 V481M possibly damaging Het
Tcerg1 A G 18: 42,574,555 K1047E probably damaging Het
Tinag T C 9: 77,031,756 K147E probably benign Het
Urgcp T C 11: 5,717,325 T338A probably damaging Het
Wdr74 C T 19: 8,739,938 R299C probably damaging Het
Zzef1 C T 11: 72,875,066 S1473L probably damaging Het
Other mutations in Lrrc74a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Lrrc74a APN 12 86754430 missense probably damaging 1.00
IGL01380:Lrrc74a APN 12 86761722 missense possibly damaging 0.62
IGL01715:Lrrc74a APN 12 86754415 missense probably benign 0.05
IGL01953:Lrrc74a APN 12 86741720 missense probably damaging 1.00
IGL02218:Lrrc74a APN 12 86749048 missense probably benign 0.15
IGL02637:Lrrc74a APN 12 86741747 nonsense probably null
IGL03397:Lrrc74a APN 12 86758538 missense probably benign 0.39
R0201:Lrrc74a UTSW 12 86761773 splice site probably benign
R0360:Lrrc74a UTSW 12 86737795 missense probably damaging 1.00
R0403:Lrrc74a UTSW 12 86740979 missense probably damaging 1.00
R0729:Lrrc74a UTSW 12 86745579 nonsense probably null
R1675:Lrrc74a UTSW 12 86741026 missense probably damaging 1.00
R1774:Lrrc74a UTSW 12 86749053 missense probably damaging 1.00
R1818:Lrrc74a UTSW 12 86737710 missense probably damaging 1.00
R4688:Lrrc74a UTSW 12 86737698 nonsense probably null
R6023:Lrrc74a UTSW 12 86758606 missense probably damaging 1.00
R6190:Lrrc74a UTSW 12 86736489 missense probably benign 0.01
R6226:Lrrc74a UTSW 12 86748457 missense possibly damaging 0.87
R6247:Lrrc74a UTSW 12 86758556 missense probably damaging 1.00
R7275:Lrrc74a UTSW 12 86740979 missense probably damaging 1.00
R7631:Lrrc74a UTSW 12 86749110 missense probably damaging 1.00
R7857:Lrrc74a UTSW 12 86741711 missense probably benign 0.00
R8172:Lrrc74a UTSW 12 86741756 missense probably damaging 1.00
X0024:Lrrc74a UTSW 12 86749045 missense probably damaging 1.00
Posted On2014-02-04