Incidental Mutation 'IGL01833:Styk1'
ID 154860
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Styk1
Ensembl Gene ENSMUSG00000032899
Gene Name serine/threonine/tyrosine kinase 1
Synonyms
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.311) question?
Stock # IGL01833
Quality Score
Status
Chromosome 6
Chromosomal Location 131276096-131330532 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to T at 131279329 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000112900 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049150] [ENSMUST00000121078]
AlphaFold Q6J9G1
Predicted Effect probably benign
Transcript: ENSMUST00000049150
SMART Domains Protein: ENSMUSP00000044098
Gene: ENSMUSG00000032899

DomainStartEndE-ValueType
transmembrane domain 31 53 N/A INTRINSIC
Pfam:Pkinase 119 387 3.2e-31 PFAM
Pfam:Pkinase_Tyr 119 387 1.8e-59 PFAM
low complexity region 399 410 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000121078
SMART Domains Protein: ENSMUSP00000112900
Gene: ENSMUSG00000032899

DomainStartEndE-ValueType
transmembrane domain 31 53 N/A INTRINSIC
Pfam:Pkinase_Tyr 67 298 2.5e-53 PFAM
Pfam:Pkinase 68 298 5.7e-29 PFAM
low complexity region 310 321 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg3 A G 17: 57,188,062 (GRCm39) N190S probably benign Het
Adamts18 T A 8: 114,469,728 (GRCm39) Y658F probably benign Het
Camsap3 T A 8: 3,658,508 (GRCm39) L1151Q probably damaging Het
Casp14 T A 10: 78,551,237 (GRCm39) Y16F probably damaging Het
Clip2 A T 5: 134,526,938 (GRCm39) probably benign Het
Clip4 G A 17: 72,134,785 (GRCm39) probably benign Het
Cyb5r4 G A 9: 86,941,505 (GRCm39) probably null Het
Ep400 A T 5: 110,827,874 (GRCm39) N2329K unknown Het
Fam163a T A 1: 155,955,742 (GRCm39) I17F probably damaging Het
Galnt1 T A 18: 24,400,617 (GRCm39) I241N probably damaging Het
Galnt14 T G 17: 73,811,899 (GRCm39) I441L probably benign Het
Gpr45 T C 1: 43,071,402 (GRCm39) L15P probably benign Het
Hivep1 A T 13: 42,308,464 (GRCm39) K235* probably null Het
Kcnip2 T C 19: 45,782,746 (GRCm39) probably null Het
Kpna3 T C 14: 61,607,894 (GRCm39) N437S possibly damaging Het
Lmtk2 A T 5: 144,112,753 (GRCm39) R1158* probably null Het
Lpo A G 11: 87,698,159 (GRCm39) V612A possibly damaging Het
Myh15 T C 16: 48,934,421 (GRCm39) C663R probably damaging Het
Nacad G A 11: 6,555,700 (GRCm39) R17C unknown Het
Or7a35 A T 10: 78,853,770 (GRCm39) M205L probably benign Het
Pcsk2 A G 2: 143,529,500 (GRCm39) Q99R possibly damaging Het
Pkd1l2 T C 8: 117,787,264 (GRCm39) N593S probably benign Het
Plce1 G A 19: 38,709,425 (GRCm39) S1093N probably damaging Het
Prxl2b G T 4: 154,981,059 (GRCm39) probably benign Het
Rhpn2 T A 7: 35,075,596 (GRCm39) Y258N probably benign Het
Serpinb9d T C 13: 33,384,688 (GRCm39) Y222H probably damaging Het
Shprh T C 10: 11,066,806 (GRCm39) L1401P probably damaging Het
Slc5a7 A G 17: 54,588,861 (GRCm39) L262P probably damaging Het
Stat2 T G 10: 128,117,045 (GRCm39) F293V probably benign Het
Stpg4 T A 17: 87,702,585 (GRCm39) probably null Het
Sult2a2 T A 7: 13,468,721 (GRCm39) D62E probably damaging Het
Sytl2 G A 7: 90,045,745 (GRCm39) V632M probably damaging Het
Themis C T 10: 28,658,307 (GRCm39) Q445* probably null Het
Tmem225 A T 9: 40,059,725 (GRCm39) E35V probably damaging Het
Vmn1r48 T A 6: 90,013,265 (GRCm39) T187S probably damaging Het
Xpnpep1 A G 19: 52,988,824 (GRCm39) Y463H probably damaging Het
Other mutations in Styk1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00822:Styk1 APN 6 131,278,625 (GRCm39) missense possibly damaging 0.75
IGL01370:Styk1 APN 6 131,278,615 (GRCm39) missense probably damaging 1.00
IGL02705:Styk1 APN 6 131,289,546 (GRCm39) missense probably benign 0.02
IGL03029:Styk1 APN 6 131,277,523 (GRCm39) missense probably benign 0.27
conviction UTSW 6 131,289,539 (GRCm39) missense probably benign 0.01
will UTSW 6 131,289,880 (GRCm39) critical splice donor site probably null
R0201:Styk1 UTSW 6 131,278,693 (GRCm39) splice site probably benign
R2267:Styk1 UTSW 6 131,289,539 (GRCm39) missense probably benign 0.01
R2268:Styk1 UTSW 6 131,289,539 (GRCm39) missense probably benign 0.01
R2269:Styk1 UTSW 6 131,289,539 (GRCm39) missense probably benign 0.01
R2919:Styk1 UTSW 6 131,289,967 (GRCm39) start gained probably benign
R3153:Styk1 UTSW 6 131,286,975 (GRCm39) nonsense probably null
R3154:Styk1 UTSW 6 131,286,975 (GRCm39) nonsense probably null
R4041:Styk1 UTSW 6 131,289,880 (GRCm39) critical splice donor site probably null
R4650:Styk1 UTSW 6 131,277,532 (GRCm39) missense probably damaging 1.00
R4739:Styk1 UTSW 6 131,277,429 (GRCm39) missense probably damaging 1.00
R5079:Styk1 UTSW 6 131,278,676 (GRCm39) missense probably damaging 1.00
R5497:Styk1 UTSW 6 131,281,670 (GRCm39) missense probably damaging 0.97
R5637:Styk1 UTSW 6 131,277,381 (GRCm39) missense possibly damaging 0.82
R6137:Styk1 UTSW 6 131,287,979 (GRCm39) missense probably damaging 1.00
R6429:Styk1 UTSW 6 131,287,027 (GRCm39) missense possibly damaging 0.93
R7522:Styk1 UTSW 6 131,289,803 (GRCm39) splice site probably null
R8188:Styk1 UTSW 6 131,281,848 (GRCm39) missense probably benign 0.43
R9255:Styk1 UTSW 6 131,286,946 (GRCm39) missense probably damaging 1.00
R9704:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9705:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9712:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9714:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9715:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9725:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9725:Styk1 UTSW 6 131,278,610 (GRCm39) small deletion probably benign
R9750:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9751:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9752:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9753:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9771:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9778:Styk1 UTSW 6 131,287,992 (GRCm39) nonsense probably null
X0021:Styk1 UTSW 6 131,284,032 (GRCm39) critical splice donor site probably null
X0026:Styk1 UTSW 6 131,287,902 (GRCm39) missense probably damaging 0.99
Posted On 2014-02-04