Incidental Mutation 'IGL01835:Vmn2r61'
ID 154913
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r61
Ensembl Gene ENSMUSG00000090967
Gene Name vomeronasal 2, receptor 61
Synonyms Gprc2a-rs2, Casr-rs2, EG637873
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # IGL01835
Quality Score
Status
Chromosome 7
Chromosomal Location 41909477-41950179 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 41950015 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 812 (M812V)
Ref Sequence ENSEMBL: ENSMUSP00000129576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166131]
AlphaFold L7N2B8
Predicted Effect probably benign
Transcript: ENSMUST00000166131
AA Change: M812V

PolyPhen 2 Score 0.123 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000129576
Gene: ENSMUSG00000090967
AA Change: M812V

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 4e-42 PFAM
Pfam:NCD3G 514 567 1.9e-21 PFAM
Pfam:7tm_3 600 835 6.2e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173044
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,213,957 (GRCm39) M728K probably benign Het
2700049A03Rik T A 12: 71,213,955 (GRCm39) Y727* probably null Het
Adam23 T C 1: 63,582,278 (GRCm39) Y309H probably damaging Het
Ash2l C T 8: 26,329,868 (GRCm39) V97M probably damaging Het
Cyp4f13 A G 17: 33,149,588 (GRCm39) F83L probably benign Het
Dnah6 A T 6: 73,112,784 (GRCm39) S1607T probably damaging Het
Dock2 T A 11: 34,260,435 (GRCm39) M969L possibly damaging Het
Dse T A 10: 34,036,213 (GRCm39) probably benign Het
Dusp22 C T 13: 30,892,666 (GRCm39) probably null Het
F5 G A 1: 164,021,937 (GRCm39) V1471I probably benign Het
Gm14403 A T 2: 177,199,049 (GRCm39) E48D probably damaging Het
Gm6309 G A 5: 146,105,085 (GRCm39) A276V probably damaging Het
Icam4 A T 9: 20,941,086 (GRCm39) T113S probably damaging Het
Ipo5 T C 14: 121,163,650 (GRCm39) V236A probably benign Het
Mrc2 T G 11: 105,227,503 (GRCm39) F579V probably damaging Het
Myl4 T A 11: 104,468,279 (GRCm39) M1K probably null Het
Oas3 A T 5: 120,904,193 (GRCm39) C560* probably null Het
Or2w25 T C 11: 59,504,165 (GRCm39) V125A probably damaging Het
Or52e18 T C 7: 104,609,669 (GRCm39) N90S probably benign Het
Prlr G A 15: 10,329,129 (GRCm39) V535I probably damaging Het
Ptprd T C 4: 76,165,058 (GRCm39) T48A probably benign Het
Rasa4 A G 5: 136,131,461 (GRCm39) H485R possibly damaging Het
Rnf13 A T 3: 57,728,007 (GRCm39) H229L probably damaging Het
Rpap3 T C 15: 97,601,120 (GRCm39) D39G possibly damaging Het
Sec23ip T A 7: 128,357,035 (GRCm39) probably null Het
Sirpa T A 2: 129,457,484 (GRCm39) F186Y possibly damaging Het
Slc26a11 T C 11: 119,268,040 (GRCm39) Y473H probably benign Het
Slc36a2 T C 11: 55,053,559 (GRCm39) I360V probably benign Het
Spg11 G A 2: 121,918,705 (GRCm39) R975C probably benign Het
Sppl2b T A 10: 80,701,175 (GRCm39) I350N probably damaging Het
Tas2r139 A T 6: 42,118,366 (GRCm39) N166I probably benign Het
Trav14n-3 A G 14: 53,607,786 (GRCm39) T39A possibly damaging Het
Vmn2r87 A C 10: 130,314,978 (GRCm39) F203V probably damaging Het
Vwde A C 6: 13,186,823 (GRCm39) V888G probably benign Het
Zbtb17 T C 4: 141,192,749 (GRCm39) probably null Het
Other mutations in Vmn2r61
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Vmn2r61 APN 7 41,950,175 (GRCm39) missense possibly damaging 0.96
IGL00824:Vmn2r61 APN 7 41,916,438 (GRCm39) missense probably benign 0.03
IGL00903:Vmn2r61 APN 7 41,949,935 (GRCm39) missense probably damaging 1.00
IGL01125:Vmn2r61 APN 7 41,909,550 (GRCm39) missense probably damaging 1.00
IGL01393:Vmn2r61 APN 7 41,916,258 (GRCm39) missense probably benign 0.08
IGL01712:Vmn2r61 APN 7 41,909,661 (GRCm39) missense probably damaging 0.98
IGL01822:Vmn2r61 APN 7 41,950,130 (GRCm39) missense probably benign 0.18
IGL01844:Vmn2r61 APN 7 41,909,639 (GRCm39) missense probably benign 0.00
IGL01953:Vmn2r61 APN 7 41,949,613 (GRCm39) missense probably damaging 1.00
IGL02032:Vmn2r61 APN 7 41,949,466 (GRCm39) missense probably damaging 0.99
IGL02054:Vmn2r61 APN 7 41,926,158 (GRCm39) critical splice donor site probably null
IGL02569:Vmn2r61 APN 7 41,926,070 (GRCm39) missense probably damaging 1.00
IGL02697:Vmn2r61 APN 7 41,924,892 (GRCm39) missense possibly damaging 0.55
IGL02958:Vmn2r61 APN 7 41,949,361 (GRCm39) missense probably benign
IGL03290:Vmn2r61 APN 7 41,915,408 (GRCm39) missense probably benign 0.00
IGL03337:Vmn2r61 APN 7 41,916,509 (GRCm39) missense possibly damaging 0.58
IGL03369:Vmn2r61 APN 7 41,909,517 (GRCm39) missense probably benign
IGL03402:Vmn2r61 APN 7 41,909,679 (GRCm39) missense probably benign
R0026:Vmn2r61 UTSW 7 41,924,898 (GRCm39) missense possibly damaging 0.64
R0319:Vmn2r61 UTSW 7 41,949,941 (GRCm39) missense probably damaging 0.99
R0433:Vmn2r61 UTSW 7 41,915,335 (GRCm39) missense probably benign 0.02
R0555:Vmn2r61 UTSW 7 41,915,442 (GRCm39) missense probably benign 0.02
R0691:Vmn2r61 UTSW 7 41,949,844 (GRCm39) missense probably damaging 1.00
R1701:Vmn2r61 UTSW 7 41,949,935 (GRCm39) missense probably damaging 1.00
R1718:Vmn2r61 UTSW 7 41,950,121 (GRCm39) missense probably benign
R1835:Vmn2r61 UTSW 7 41,916,076 (GRCm39) nonsense probably null
R1920:Vmn2r61 UTSW 7 41,949,710 (GRCm39) missense possibly damaging 0.73
R2069:Vmn2r61 UTSW 7 41,949,425 (GRCm39) missense probably benign 0.06
R2326:Vmn2r61 UTSW 7 41,916,287 (GRCm39) missense probably damaging 1.00
R2402:Vmn2r61 UTSW 7 41,949,529 (GRCm39) missense possibly damaging 0.90
R3103:Vmn2r61 UTSW 7 41,916,067 (GRCm39) missense possibly damaging 0.73
R3107:Vmn2r61 UTSW 7 41,916,491 (GRCm39) missense possibly damaging 0.82
R4426:Vmn2r61 UTSW 7 41,950,159 (GRCm39) missense probably benign
R4426:Vmn2r61 UTSW 7 41,950,157 (GRCm39) missense probably benign
R4484:Vmn2r61 UTSW 7 41,950,120 (GRCm39) missense probably benign
R4748:Vmn2r61 UTSW 7 41,916,565 (GRCm39) missense probably damaging 0.96
R4835:Vmn2r61 UTSW 7 41,916,459 (GRCm39) missense possibly damaging 0.52
R4863:Vmn2r61 UTSW 7 41,950,132 (GRCm39) missense probably benign 0.03
R4923:Vmn2r61 UTSW 7 41,916,520 (GRCm39) missense probably damaging 1.00
R4968:Vmn2r61 UTSW 7 41,949,478 (GRCm39) missense probably benign 0.14
R5114:Vmn2r61 UTSW 7 41,949,953 (GRCm39) missense possibly damaging 0.92
R5297:Vmn2r61 UTSW 7 41,909,646 (GRCm39) missense probably benign
R5497:Vmn2r61 UTSW 7 41,924,906 (GRCm39) missense possibly damaging 0.95
R5508:Vmn2r61 UTSW 7 41,916,242 (GRCm39) missense possibly damaging 0.52
R5587:Vmn2r61 UTSW 7 41,949,911 (GRCm39) missense probably damaging 1.00
R5615:Vmn2r61 UTSW 7 41,949,917 (GRCm39) missense probably damaging 1.00
R5615:Vmn2r61 UTSW 7 41,916,677 (GRCm39) missense probably benign 0.00
R5782:Vmn2r61 UTSW 7 41,949,253 (GRCm39) missense probably damaging 1.00
R6136:Vmn2r61 UTSW 7 41,916,455 (GRCm39) missense probably damaging 1.00
R6207:Vmn2r61 UTSW 7 41,909,616 (GRCm39) missense probably benign 0.01
R6265:Vmn2r61 UTSW 7 41,915,915 (GRCm39) missense probably benign 0.01
R6272:Vmn2r61 UTSW 7 41,949,242 (GRCm39) missense probably damaging 1.00
R6355:Vmn2r61 UTSW 7 41,916,659 (GRCm39) missense probably benign 0.00
R6469:Vmn2r61 UTSW 7 41,915,283 (GRCm39) nonsense probably null
R6554:Vmn2r61 UTSW 7 41,926,139 (GRCm39) missense probably damaging 1.00
R6699:Vmn2r61 UTSW 7 41,949,580 (GRCm39) missense probably benign
R6768:Vmn2r61 UTSW 7 41,949,748 (GRCm39) missense probably damaging 1.00
R6824:Vmn2r61 UTSW 7 41,949,403 (GRCm39) missense probably benign 0.10
R6930:Vmn2r61 UTSW 7 41,949,364 (GRCm39) missense probably benign 0.02
R7053:Vmn2r61 UTSW 7 41,916,557 (GRCm39) missense probably damaging 0.96
R7238:Vmn2r61 UTSW 7 41,916,629 (GRCm39) missense possibly damaging 0.73
R7332:Vmn2r61 UTSW 7 41,909,534 (GRCm39) missense probably benign 0.00
R7359:Vmn2r61 UTSW 7 41,915,407 (GRCm39) missense probably benign 0.11
R7553:Vmn2r61 UTSW 7 41,916,205 (GRCm39) missense not run
R7710:Vmn2r61 UTSW 7 41,916,472 (GRCm39) missense probably damaging 1.00
R7732:Vmn2r61 UTSW 7 41,916,097 (GRCm39) missense probably benign
R7839:Vmn2r61 UTSW 7 41,916,032 (GRCm39) missense probably damaging 0.97
R7916:Vmn2r61 UTSW 7 41,949,935 (GRCm39) missense probably damaging 1.00
R8026:Vmn2r61 UTSW 7 41,916,141 (GRCm39) missense probably benign 0.02
R8440:Vmn2r61 UTSW 7 41,916,080 (GRCm39) missense probably benign 0.02
R8499:Vmn2r61 UTSW 7 41,949,700 (GRCm39) missense probably damaging 0.99
R8771:Vmn2r61 UTSW 7 41,916,194 (GRCm39) missense probably damaging 0.99
R8847:Vmn2r61 UTSW 7 41,950,010 (GRCm39) missense probably damaging 1.00
R8986:Vmn2r61 UTSW 7 41,915,325 (GRCm39) nonsense probably null
R9290:Vmn2r61 UTSW 7 41,915,385 (GRCm39) missense probably benign 0.27
R9311:Vmn2r61 UTSW 7 41,950,092 (GRCm39) missense possibly damaging 0.92
R9324:Vmn2r61 UTSW 7 41,916,619 (GRCm39) missense probably benign 0.00
R9476:Vmn2r61 UTSW 7 41,949,593 (GRCm39) missense probably damaging 1.00
R9521:Vmn2r61 UTSW 7 41,916,626 (GRCm39) missense probably damaging 0.99
R9619:Vmn2r61 UTSW 7 41,926,136 (GRCm39) missense probably damaging 0.98
R9729:Vmn2r61 UTSW 7 41,949,917 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r61 UTSW 7 41,949,388 (GRCm39) missense possibly damaging 0.93
Z1176:Vmn2r61 UTSW 7 41,916,166 (GRCm39) missense probably benign 0.00
Z1176:Vmn2r61 UTSW 7 41,909,585 (GRCm39) missense possibly damaging 0.46
Posted On 2014-02-04