Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01835:Oas3'

154930

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Oas3

Ensembl Gene

ENSMUSG00000032661

Gene Name

2'-5' oligoadenylate synthetase 3

Synonyms

Oasl10, 2'-5' oligoadenylate synthetase-like 10

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL01835

Quality Score

Status

Chromosome

Chromosomal Location

120753098-120777661 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 120766128 bp

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 560 (C560*)

Ref Sequence

ENSEMBL: ENSMUSP00000035588 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044833]

Predicted Effect

probably null
Transcript: ENSMUST00000044833
AA Change: C560*

SMART Domains

Protein: ENSMUSP00000035588
Gene: ENSMUSG00000032661
AA Change: C560*

Domain	Start	End	E-Value	Type
Pfam:OAS1_C	159	341	6.3e-83	PFAM
Pfam:OAS1_C	610	795	3.1e-78	PFAM
Pfam:NTP_transf_2	831	920	4.5e-11	PFAM
Pfam:OAS1_C	954	1136	9e-85	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000166703

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	T	A	12: 71,167,181	Y727*	probably null	Het
2700049A03Rik	T	A	12: 71,167,183	M728K	probably benign	Het
Adam23	T	C	1: 63,543,119	Y309H	probably damaging	Het
Ash2l	C	T	8: 25,839,840	V97M	probably damaging	Het
Cyp4f13	A	G	17: 32,930,614	F83L	probably benign	Het
Dnah6	A	T	6: 73,135,801	S1607T	probably damaging	Het
Dock2	T	A	11: 34,310,435	M969L	possibly damaging	Het
Dse	T	A	10: 34,160,217		probably benign	Het
Dusp22	C	T	13: 30,708,683		probably null	Het
F5	G	A	1: 164,194,368	V1471I	probably benign	Het
Gm14403	A	T	2: 177,507,256	E48D	probably damaging	Het
Gm6309	G	A	5: 146,168,275	A276V	probably damaging	Het
Icam4	A	T	9: 21,029,790	T113S	probably damaging	Het
Ipo5	T	C	14: 120,926,238	V236A	probably benign	Het
Mrc2	T	G	11: 105,336,677	F579V	probably damaging	Het
Myl4	T	A	11: 104,577,453	M1K	probably null	Het
Olfr225	T	C	11: 59,613,339	V125A	probably damaging	Het
Olfr670	T	C	7: 104,960,462	N90S	probably benign	Het
Prlr	G	A	15: 10,329,043	V535I	probably damaging	Het
Ptprd	T	C	4: 76,246,821	T48A	probably benign	Het
Rasa4	A	G	5: 136,102,607	H485R	possibly damaging	Het
Rnf13	A	T	3: 57,820,586	H229L	probably damaging	Het
Rpap3	T	C	15: 97,703,239	D39G	possibly damaging	Het
Sec23ip	T	A	7: 128,755,311		probably null	Het
Sirpa	T	A	2: 129,615,564	F186Y	possibly damaging	Het
Slc26a11	T	C	11: 119,377,214	Y473H	probably benign	Het
Slc36a2	T	C	11: 55,162,733	I360V	probably benign	Het
Spg11	G	A	2: 122,088,224	R975C	probably benign	Het
Sppl2b	T	A	10: 80,865,341	I350N	probably damaging	Het
Tas2r139	A	T	6: 42,141,432	N166I	probably benign	Het
Trav14n-3	A	G	14: 53,370,329	T39A	possibly damaging	Het
Vmn2r61	A	G	7: 42,300,591	M812V	probably benign	Het
Vmn2r87	A	C	10: 130,479,109	F203V	probably damaging	Het
Vwde	A	C	6: 13,186,824	V888G	probably benign	Het
Zbtb17	T	C	4: 141,465,438		probably null	Het

Other mutations in Oas3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00547:Oas3	APN	5	120777442	splice site	probably benign
IGL01095:Oas3	APN	5	120772889	missense	probably damaging	1.00
IGL02006:Oas3	APN	5	120769235	missense	probably benign	0.00
IGL02811:Oas3	APN	5	120764322	missense	unknown
IGL03194:Oas3	APN	5	120758953	missense	probably damaging	1.00
R0066:Oas3	UTSW	5	120758875	missense	probably damaging	1.00
R0195:Oas3	UTSW	5	120756145	missense	probably damaging	1.00
R0196:Oas3	UTSW	5	120756145	missense	probably damaging	1.00
R0197:Oas3	UTSW	5	120756145	missense	probably damaging	1.00
R0445:Oas3	UTSW	5	120756145	missense	probably damaging	1.00
R0523:Oas3	UTSW	5	120766144	missense	unknown
R0592:Oas3	UTSW	5	120771149	missense	probably damaging	1.00
R0946:Oas3	UTSW	5	120769063	missense	unknown
R1354:Oas3	UTSW	5	120770000	missense	possibly damaging	0.94
R1642:Oas3	UTSW	5	120777574	missense	possibly damaging	0.90
R1681:Oas3	UTSW	5	120769908	missense	probably benign	0.22
R1844:Oas3	UTSW	5	120759980	missense	probably damaging	0.99
R1981:Oas3	UTSW	5	120761835	splice site	probably benign
R2443:Oas3	UTSW	5	120777488	missense	probably benign	0.35
R2902:Oas3	UTSW	5	120758917	missense	probably damaging	1.00
R3034:Oas3	UTSW	5	120771056	missense	probably damaging	1.00
R4565:Oas3	UTSW	5	120771039	missense	probably damaging	1.00
R4692:Oas3	UTSW	5	120769355	missense	probably benign	0.03
R4723:Oas3	UTSW	5	120766256	missense	unknown
R4812:Oas3	UTSW	5	120761147	unclassified	probably benign
R5288:Oas3	UTSW	5	120756990	missense	probably damaging	1.00
R5343:Oas3	UTSW	5	120756238	missense	possibly damaging	0.70
R5494:Oas3	UTSW	5	120761644	missense	unknown
R5688:Oas3	UTSW	5	120758802	missense	probably benign	0.31
R5894:Oas3	UTSW	5	120756954	missense	probably damaging	1.00
R5921:Oas3	UTSW	5	120769981	missense	probably damaging	1.00
R6037:Oas3	UTSW	5	120769319	missense	probably benign	0.41
R6037:Oas3	UTSW	5	120769319	missense	probably benign	0.41
R6066:Oas3	UTSW	5	120772924	missense	probably damaging	0.97
R6104:Oas3	UTSW	5	120761693	missense	unknown
R6134:Oas3	UTSW	5	120769048	missense	unknown
R6255:Oas3	UTSW	5	120771230	missense	probably benign	0.04
R6257:Oas3	UTSW	5	120761135	unclassified	probably benign
R6776:Oas3	UTSW	5	120758874	missense	probably damaging	1.00
R8022:Oas3	UTSW	5	120756966	missense	possibly damaging	0.91
R8137:Oas3	UTSW	5	120777500	missense	probably benign	0.07
RF006:Oas3	UTSW	5	120774100	missense	probably damaging	1.00
X0024:Oas3	UTSW	5	120761728	missense	unknown

Posted On

2014-02-04