Incidental Mutation 'IGL01836:Olfr342'
ID154946
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr342
Ensembl Gene ENSMUSG00000111869
Gene Nameolfactory receptor 342
SynonymsMOR136-4, GA_x6K02T2NLDC-33222024-33222962
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.140) question?
Stock #IGL01836
Quality Score
Status
Chromosome2
Chromosomal Location36524998-36530790 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to T at 36527825 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Stop codon at position 138 (Q138*)
Ref Sequence ENSEMBL: ENSMUSP00000149751 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074192] [ENSMUST00000216275]
Predicted Effect probably null
Transcript: ENSMUST00000074192
AA Change: Q138*
SMART Domains Protein: ENSMUSP00000073818
Gene: ENSMUSG00000111869
AA Change: Q138*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.7e-56 PFAM
Pfam:7tm_1 41 290 2e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213794
Predicted Effect probably null
Transcript: ENSMUST00000216275
AA Change: Q138*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adh6a A G 3: 138,313,336 probably benign Het
Atp1a1 C T 3: 101,591,414 G188R probably damaging Het
Cadps A G 14: 12,522,311 Y618H probably damaging Het
Dot1l T C 10: 80,785,866 S451P probably benign Het
Dpysl4 G A 7: 139,096,173 V294I possibly damaging Het
Ehmt1 T A 2: 24,863,220 probably null Het
Eps8 C T 6: 137,483,541 probably null Het
Gm7247 T A 14: 51,365,396 I63K probably damaging Het
Gsdme T A 6: 50,222,789 D270V probably damaging Het
Kel T A 6: 41,697,438 T353S possibly damaging Het
Krt73 T C 15: 101,795,896 H403R probably benign Het
Mrnip A G 11: 50,199,848 T280A probably benign Het
Pkdrej A G 15: 85,820,958 L259P probably damaging Het
Plod2 T C 9: 92,606,498 probably benign Het
Rad54l2 A G 9: 106,716,157 S415P probably benign Het
Rag1 A T 2: 101,641,894 F968I probably damaging Het
Rreb1 T C 13: 37,931,457 S931P probably damaging Het
Sec23a T C 12: 58,971,287 I618V probably damaging Het
Smtnl1 A T 2: 84,815,370 F386I probably damaging Het
Sppl2b C T 10: 80,861,386 T30I probably benign Het
Srf T C 17: 46,549,182 probably benign Het
Tbc1d22b A G 17: 29,599,958 T429A probably damaging Het
Tcf20 A T 15: 82,855,155 D698E probably damaging Het
Tmem106c C A 15: 97,969,686 S250R probably benign Het
Tmprss3 A G 17: 31,191,044 S199P probably benign Het
Ush2a C T 1: 188,759,863 probably benign Het
Zfp595 A G 13: 67,332,461 probably benign Het
Other mutations in Olfr342
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Olfr342 APN 2 36527993 missense probably benign 0.22
IGL01372:Olfr342 APN 2 36527451 missense probably benign 0.00
IGL01747:Olfr342 APN 2 36527832 missense probably damaging 1.00
IGL02409:Olfr342 APN 2 36528153 missense probably damaging 1.00
IGL02578:Olfr342 APN 2 36528144 missense probably damaging 1.00
IGL03344:Olfr342 APN 2 36528128 missense probably damaging 1.00
IGL03396:Olfr342 APN 2 36527680 missense probably benign 0.00
R0086:Olfr342 UTSW 2 36527450 missense possibly damaging 0.69
R0427:Olfr342 UTSW 2 36527982 missense probably damaging 1.00
R0973:Olfr342 UTSW 2 36528008 missense probably benign 0.13
R0973:Olfr342 UTSW 2 36528008 missense probably benign 0.13
R0974:Olfr342 UTSW 2 36528008 missense probably benign 0.13
R2183:Olfr342 UTSW 2 36527711 nonsense probably null
R2437:Olfr342 UTSW 2 36528246 missense probably damaging 1.00
R4060:Olfr342 UTSW 2 36527414 start codon destroyed probably null 0.01
R4982:Olfr342 UTSW 2 36527397 critical splice acceptor site probably null
R5070:Olfr342 UTSW 2 36527766 missense probably damaging 1.00
R6244:Olfr342 UTSW 2 36528341 missense probably benign 0.00
R8350:Olfr342 UTSW 2 36528164 missense probably damaging 1.00
R8690:Olfr342 UTSW 2 36528195 missense probably benign 0.22
Posted On2014-02-04