Incidental Mutation 'IGL01836:Mrnip'
ID154954
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrnip
Ensembl Gene ENSMUSG00000020381
Gene NameMRN complex interacting protein
Synonyms3010026O09Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01836
Quality Score
Status
Chromosome11
Chromosomal Location50174444-50200115 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 50199848 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 280 (T280A)
Ref Sequence ENSEMBL: ENSMUSP00000020647 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000015981] [ENSMUST00000020647] [ENSMUST00000102774] [ENSMUST00000123164] [ENSMUST00000136936] [ENSMUST00000143379]
Predicted Effect probably benign
Transcript: ENSMUST00000015981
SMART Domains Protein: ENSMUSP00000015981
Gene: ENSMUSG00000015837

DomainStartEndE-ValueType
PB1 3 102 1.96e-14 SMART
ZnF_ZZ 122 165 8.62e-19 SMART
low complexity region 269 281 N/A INTRINSIC
UBA 358 397 9.33e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000020647
AA Change: T280A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect probably benign
Transcript: ENSMUST00000102774
SMART Domains Protein: ENSMUSP00000099835
Gene: ENSMUSG00000015837

DomainStartEndE-ValueType
PB1 3 102 1.96e-14 SMART
ZnF_ZZ 122 165 8.62e-19 SMART
low complexity region 269 281 N/A INTRINSIC
UBA 396 435 9.33e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000123164
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131214
Predicted Effect probably benign
Transcript: ENSMUST00000136936
SMART Domains Protein: ENSMUSP00000120442
Gene: ENSMUSG00000015837

DomainStartEndE-ValueType
UBA 63 102 9.33e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000143379
SMART Domains Protein: ENSMUSP00000118662
Gene: ENSMUSG00000015837

DomainStartEndE-ValueType
PB1 3 102 1.96e-14 SMART
ZnF_ZZ 122 165 8.62e-19 SMART
low complexity region 269 281 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147846
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adh6a A G 3: 138,313,336 probably benign Het
Atp1a1 C T 3: 101,591,414 G188R probably damaging Het
Cadps A G 14: 12,522,311 Y618H probably damaging Het
Dot1l T C 10: 80,785,866 S451P probably benign Het
Dpysl4 G A 7: 139,096,173 V294I possibly damaging Het
Ehmt1 T A 2: 24,863,220 probably null Het
Eps8 C T 6: 137,483,541 probably null Het
Gm7247 T A 14: 51,365,396 I63K probably damaging Het
Gsdme T A 6: 50,222,789 D270V probably damaging Het
Kel T A 6: 41,697,438 T353S possibly damaging Het
Krt73 T C 15: 101,795,896 H403R probably benign Het
Olfr342 C T 2: 36,527,825 Q138* probably null Het
Pkdrej A G 15: 85,820,958 L259P probably damaging Het
Plod2 T C 9: 92,606,498 probably benign Het
Rad54l2 A G 9: 106,716,157 S415P probably benign Het
Rag1 A T 2: 101,641,894 F968I probably damaging Het
Rreb1 T C 13: 37,931,457 S931P probably damaging Het
Sec23a T C 12: 58,971,287 I618V probably damaging Het
Smtnl1 A T 2: 84,815,370 F386I probably damaging Het
Sppl2b C T 10: 80,861,386 T30I probably benign Het
Srf T C 17: 46,549,182 probably benign Het
Tbc1d22b A G 17: 29,599,958 T429A probably damaging Het
Tcf20 A T 15: 82,855,155 D698E probably damaging Het
Tmem106c C A 15: 97,969,686 S250R probably benign Het
Tmprss3 A G 17: 31,191,044 S199P probably benign Het
Ush2a C T 1: 188,759,863 probably benign Het
Zfp595 A G 13: 67,332,461 probably benign Het
Other mutations in Mrnip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01518:Mrnip APN 11 50197635 missense probably damaging 0.99
IGL02080:Mrnip APN 11 50197675 missense probably benign 0.00
IGL03059:Mrnip APN 11 50199769 missense probably damaging 1.00
IGL03381:Mrnip APN 11 50199590 missense probably benign
R0391:Mrnip UTSW 11 50199920 missense probably damaging 0.99
R1388:Mrnip UTSW 11 50196945 missense probably benign 0.02
R1561:Mrnip UTSW 11 50176849 missense probably damaging 1.00
R1736:Mrnip UTSW 11 50176891 splice site probably null
R1768:Mrnip UTSW 11 50176861 missense probably damaging 1.00
R5660:Mrnip UTSW 11 50197091 missense probably null 1.00
R6505:Mrnip UTSW 11 50199852 missense possibly damaging 0.92
R6803:Mrnip UTSW 11 50199903 missense probably benign
R7290:Mrnip UTSW 11 50196981 missense possibly damaging 0.71
R7735:Mrnip UTSW 11 50196973 nonsense probably null
R8462:Mrnip UTSW 11 50199827 missense probably benign 0.31
R8826:Mrnip UTSW 11 50176861 missense probably damaging 1.00
Posted On2014-02-04